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Dopamine Receptors in Parkinson's Disease: A Meta-Analysis of Imaging Studies
Dopamine receptors are abundant along the central nigrostriatal tract and are expressed as 5 subtypes in two receptor families. In PD, compensatory changes in dopamine receptors emerge as a consequence of the loss of ...
Short- and long-term outcomes of infective endocarditis admission in adults: A population-based registry study in Finland
<p>Infective endocarditis (IE) is associated with high mortality. However, data on factors associated with length of stay (LOS) in hospital due to IE are scarce. In addition, long-term mortality of more than 1 year is ...
Prediagnostic expressions in health records predict mortality in Parkinson's disease: A proof-of-concept study
<p><br></p><p>Introduction: The relationship of prodromal markers of PD with PD mortality is unclear. Electronic health records (EHRs) provide a large source of raw data that could be useful in the identification of novel ...
Cognitive functions and symptoms predicting later use of psychiatric services following mild traumatic brain injury in school-age
<p><strong>Objective: </strong>To investigate whether neuropsychological test performance or presence of some specific injury symptoms at 1-3 months following pediatric mild traumatic brain injury (mTBI) can help to identify the children at risk for developing post-traumatic psychiatric symptoms.</p><p><strong>Methods: </strong>Data from 120 children and adolescents aged 7-15 years, treated at Turku University Hospital between 2010 and 2016 due to mTBI, and who had undergone neuropsychological evaluation at 1-3 months following injury, were enrolled from the hospital records. Neuropsychological test performancesand injury symptom reports were retrospectively retrieved from the patient files.</p><p><strong>Results: </strong>Slow information processing speed (p = 0.044), emotion regulation deficit (p = 0.014), impulsivity (p = 0.013), verbal processing difficulties (p = 0.042) and headache (p = 0.026) were independent predictors for having later contact in psychiatric care.</p><p><strong>Conclusions: </strong>Neuropsychological examination containing measure of information processing speed, injury symptom interview, and parental questionnaires on behavioural issues of the child at 1-3 months following mTBI seems to be useful in detecting children with risk for post traumatic psychiatric symptoms. Targeted support and guidance for this group of children and adolescents and their families are recommended to prevent the development of an unfavorable psychosocial outcome.</p><p><strong>Keywords: </strong>Traumatic brain injury; adolescents; children; mild traumatic brain injury; pediatric; psychiatric.</p>...
Effect of Inhaled Xenon on Cardiac Function in Comatose Survivors of Out-of-Hospital Cardiac Arrest—A Substudy of the Xenon in Combination With Hypothermia After Cardiac Arrest Trial
<p>OBJECTIVES: This explorative substudy aimed at determining the effect of<br>inhaled xenon on left ventricular function by echocardiography in comatose survivors<br>of out-of-hospital cardiac arrest.<br>DESIGN: A randomized ...
Diagnostic value of micrographia in Parkinson's disease: a study with [I-123]FP-CIT SPECT
<p>Micrographia is a common symptom of Parkinson's disease (PD), and it may precede other motor symptoms. Despite the high prevalence of micrographia in PD, its neurobiological mechanisms are not known. Given that levodopa ...
Cannabinoid Receptor Type 1 in Parkinson's Disease: A Positron Emission Tomography Study with [F-18]FMPEP-d(2)
<p><b>Background:</b> The endocannabinoid system is a widespread neuromodulatory system affecting several biological functions and processes. High densities of type 1 cannabinoid (CB1) receptors and endocannabinoids are ...