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A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

Schwarz PEH; Zhao JH; Eriksson JG; Kinnunen L; Luan JA; Raitakari OT; Kooner JS; Hassinen M; Ribel-Madsen R; Feitosa MF; Abecasis GR; Mangino M; Kanoni S; Chu AY; Wild SH; Milani L; Pankow JS; Medina-Gomez C; Oostra BA; Boehnke M; Goel A; Beilby J; Wong A; Prokopenko I; Pedersen O; Polasek O; Grewal J; Morris AP; Kajantie E; Perola M; Peters A; Hysi PG; Jokinen E; Spector TD; Mills R; Muller-Nurasyid M; Kutalik Z; Vitart V; Ohlsson C; Walker RW; Bellis C; Hui JN; Viikari JS; Justesen JM; Friedrich N; Albrecht E; Lahti J; Southam L; Tsafantakis E; Lichtner P; Hayward C; Rankinen T; Thorleifsson G; Mohlke KL; Willemsen G; Lakka TA; Hastie N; Husemoen LL; Chasman DI; McArdle WL; Watkins H; Mcknight B; Metspalu A; Palotie A; North KE; Scott RA; Cupples LA; Venturini C; Grarup N; Bragg-Gresham JL; Laitinen T; Teumer A; Ryan KA; Isaacs A; Njolstad I; Rauramaa R; Grassler J; Khaw KT; van der Harst P; Mannisto S; Salvi E; Graff M; Uitterlinden AG; Loos RJF; Bluher M; Hattersley AT; Esko T; Wang SR; Schlessinger D; Huffman JE; Kooner IK; Montasser ME; Willems SM; Bouchard C; van der Most PJ; Kolcic I; Tuomilehto J; Chambers JC; Boomsma DI; Bornstein SR; Pilia MG; Gieger C; Grallert H; Rao DC; Forouhi NG; Hansen T; Lewin AM; Heid IM; Blangero J; Palmer LJ; Fox C; Chines PS; Tonjes A; Hveem K; Penninx BW; Bonnycastle LL; Bruinenberg M; Vohl MC; Wilsgaard T; Stringham HM; Kovacs P; Oldehinkel AJ; Jarvelin MR; Ong KK; Hillege H; Harder MN; Stancakova A; Tachmazidou I; Strauch K; Monda KL; Doring A; Jackson AU; Hamsten A; Bakker SJL; Steinthorsdottir V; van Dongen J; Bergman RN; Bergmann S; Lindgren CM; Eklund N; Shudiner AR; Vartiainen E; Stefansson K; Smit JH; Van Vliet-Ostaptchouk JV; Kuusisto J; Musk AW; Lehtimaki T; Hartman CA; Frayling T; Thorsteinsdottir U; Qi L; Heliovaara M; Hottenga JJ; Salomaa V; Jorgensen T; Wright AF; Tremblay A; Knekt PB; Muller G; Holmen O; Lyssenko V; Kyriakou T; Volker U; Ferreira T; Jalilzadeh S; Jeff JM; Ridker PM; Gansevoort RT; Boerwinkle E; Borecki IB; D'Avila F; Hirschhorn JN; Magi R; Luben R; Sarzynski MA; Barlassina C; Kaplan RC; Cadby G; Ahluwalia TS; Zhang WH; Gjesing AP; Puolijoki H; Cusi D; Smith MT; Koskinen S; Widen E; Manunta P; Zillikens MC; Chiang CWK; Strachan DP; Rice TK; Winkler TW; Hofman A; Kristiansson K; Swertz MA; Koistinen HA; Sparso TH; Farrall M; Havulinna AS; Campbell H; Lindstrom J; Wilson JF; Snieder H; Sorensen TIA; Linneberg A; Uusitupa M; Dimitriou M; O'Connell JR; Eriksson J; Vollenweider P; Jula A; Zeggini E; Deloukas P; Dedoussis G; Farmaki AE; Langenberg C; Scholtens S; van Duijn CM; Mahajan A; Bartz TM; Richards M; Psaty BM; Rivadeneira F; Vandenput L; Justice AE; Cucca F; Hunter DJ; Fischer K; Jousilahti P; Homuth G; Vonk JM; Mihailov E; Perusse L; Sebert S; McCarthy MI; Heard-Costa NL; Leach IM; Nolte IM; Wareham NJ; Yerges-Armstrong LM; Ried JS; Karaleftheri M; Pramstaller PP; Pichler I; Stolk RP; Groop LC; James AL; Swift AJ; Glorioso N; Verweij N; Rose LM; Waeber G; Narisu N; Sung YJ; Rayner NW; Collins FS; Lorbeer R; Hicks AA; Sanna S; Laakso M; Chen YDI; Stirrups K; Osmond C; Paternoster L; Lorentzon M; Ittermann T; Rudan I; Hu F; de Geus EJC; Kahonen M; Gorski M; Stumvoll M; Alves AC; Kuh D; Keinanen-Kiukaanniemi SM

Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a ...

Genetic loci associated with heart rate variability and their effects on cardiac disease risk

Minassian A; Thayer JF; Boomsma D; Kumari M; Nolte IM; van der Harst P; Riese H; Christophersen IE; Teumer A; Sotoodehnia N; Maihofer AX; Avery CL; Kahonen M; Staessen JA; Rioux JD; Voss A; Kluttig A; Morris AP; Sundstrom J; Vaez A; Huikuri H; zu Schwabedissen HM; Lindgren CM; Zonderman AB; Huikari V; Wilhelmsen KC; Reiner AP; Albarwani S; North KE; Stilp AM; Bis JC; Nivard M; Wong A; Navis G; Stolarz-Skrzypek K; Ellinor PT; Zhang ZM; McKnight B; Whitsel EA; Albert C; Giedraitis V; Heckbert SR; Baker DG; Neijts M; Stein PK; Jansen R; Milaneschi Y; Hwang SJ; Liao DP; Perz S; Geyer MA; Li Y; van Roon AM; Rotter JI; Boucher G; Ormel J; Zafarmand MH; O'Connor DT; van der Most PJ; Verweij N; de Bakker PIW; Friberg P; Hutri-Kahonen N; Axelsson T; Cusi D; Amare AT; Soliman EZ; Asselbergs FW; Abdellaoui A; Britton AR; Salvi E; Gogarten SM; Penninx B; Hassan M; Mahajan A; Lind L; Nikus K; Smith NL; Lyytikainen LP; Kiviniemi AM; Greiser HK; Wong QN; Kooperberg C; van Dongen J; Lin HJ; Uitterlinden AG; Kivimaki M; Jarvelin MR; Kuznetsova T; Sofer T; Syvanen AC; Evans MK; Sinner MF; Nievergelt CM; O'Donnell CJ; Siscovick D; von der Heyde B; Psaty BM; Lubitz SA; Smit JH; Munoz ML; Hofman A; Floras JS; Franco OH; Stricker BH; Gademan MGJ; Bieringa RJ; de Geus EJC; Taylor KD; Hemerich D; Snieder H; Dietrich A; Barcella M; Kaab S; van Setten J; Brundel BJJM; Ingelsson E; Jaju D; Stewart JD; Strauch K; Kerr KF; Tiemeier H; Vrijkotte TGM; Willemsen G; Laurie CC; van der Laan SW; Hartman CA; Tragante V; Goyette P; Swenne CA; Hottenga JJ; Thornton TA; Risbrough VB; Oldehinkel AJ; Felix JF; Tardif JC; Kumar J; Mononen N; Zabaneh D; Muller-Nurasyid M; Ashar F; Limacher MC; Eskola M; Peters A; Lefrandt JD; Ehret GB; den Hoed M; Juonala M; Lehtimaki T; Hernesniemi J; Alonso A; Dierckx B; Auvinen J; Nalls MA; Raitakari OT; Kuh D; Kors JA; Krijthe BP; Bayoumi R; Waldenberger M; Tinker LE

Reduced cardiac vagal control reflected in low heart rate variability (HRV) is associated with greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide association studies for three HRV ...

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Harris TB; Tuomilehto J; Harder MN; James AL; Silbernagel G; Hutri-Kahonen N; Rudan I; Navarro P; Mahajan A; Kolcic I; Kutalik Z; Jackson AU; Balkau B; Marten J; Rankinen T; Stott DJ; Bandinelli S; Liu CT; Schlessinger D; Bien SA; Vestergaard H; Direk N; Holmen OL; van der Laan SW; Alfred T; Scholtens S; Marques-Vidal P; Olden M; Fisher VA; Hocking LJ; Kleber ME; Frayling TM; Eicher JD; Launer LJ; Lim U; Xue L; Lee NR; Lehtimaki T; Metspalu A; Rao DC; Jarvelin MR; Pervjakova N; Rasmussen-Torvik LJ; Chittani M; Strauch K; Lindgren CM; Qi L; Bergmann S; Volzke H; Heid IM; Strachan DP; Hottenga JJ; Hansen T; Haitjema S; Sorensen TIA; Kuh D; Bergman RN; Pasterkamp G; Sennblad B; McCarthy MI; Gong J; Nauck M; Bartz TM; Waeber G; Chasman DI; Strawbridge RJ; Dedoussis G; Justice AE; Wild S; Faul JD; Taylor KD; Chu AY; Hollensted M; Vedantam SL; Raitakari OT; Rauramaa R; Loh M; Eriksson J; Justesen JM; Savonen K; Cupples LA; Borecki IB; Fox CS; Hastie ND; Kivimaki M; Gudnason V; Heath AC; Narisu N; Madden PAF; Mohlke KL; Pisinger C; Wu Y; Eiriksdottir G; Barroso I; Perez J; Musk AW; Heard-Costa NL; Ludolph-Donislawski A; Lind L; Bonnycastle LL; Tyrrell J; Bragg J; Zhao W; Kvaloy K; Hassinen M; Lim E; Rice T; Hadley D; Froguel P; Winkler TW; Padmanabhan S; Gorski M; Chambers JC; Weir DR; Grabe HJ; Hirschhorn JN; Barata L; Curran JE; Campbell H; Peters U; Boehnke M; Peters A; Deng X; Langenberg C; Wilson JF; Loos RJF; de Borst GJ; Zubair N; Marchini J; Tayo BO; Afzal U; Hamsten A; Deloukas P; Hindorff L; Esko T; Chen YDI; Cusi D; Baldassarre D; Palmer LJ; Mellstrom D; Hayward C; de Faire U; Wright AF; Grallert H; Glorioso N; Scott RA; Linneberg A; Kinnunen L; Sarti C; Collins FS; Lorentzon M; Hernandez D; Spector TD; Forrester T; Schurmann C; Hung J; Luben R; Zhang WH; Grammer TB; Smith JA; Middelberg RPS; Smith BH; Oldehinkel AJ; Bielak LF; Johnson AD; Boomsma DI; Jhun MA; Vink JM; Stringham HM; Ingelsson E; Marz W; Zillikens MC; Bakker SJL; North KE; Kramer BK; Gigante B; Jansson JO; Huang J; Kooner JS; Graff M; Bonnefond A; Kardia SLR; Jorgensen ME; Kahonen M; Vonk JM; Polasek O; Ong KK; Corre T; Vollenweider P; Morris AP; Perusse L; Gertow K; Hveem K; Tiemeier H; Franks PW; Slagboom PE; Zimmermann ME; Martin NG; Sanna S; Biffar R; Bottinger E; Ohlsson C; McKnight B; Czajkowski J; Hunter DJ; Stancakova A; Horikoshi M; van der Most PJ; Verweij N; Thuillier D; Komulainen P; Ridker PM; Boerwinkle E; Peyser PA; Waldenberger M; Ferrucci L; Van Vliet-Ostaptchouk JV; Chines PS; Van der Harst P; Staessen JA; Psaty BM; Delgado GE; Rose LM; Afaq S; Eriksson AL; Hartman CA; Boger CA; Beilby J; Grarup N; Adair LS; Young K; Mannikko R; Haiman CA; van Duijn CM; Sarzynski MA; Mueller-Nurasyid M; Ford I; Manichaikul A; Huang T; Rawal R; Amin N; Westendorp RGJ; Nolte IM; Wolffenbuttel BHR; Koistinen HA; Swertz MA; Wu J; Laakso M; Smith AV; Montgomery GW; Fischer K; Willemsen G; Wong A; Le Marchand L; Leander K; Blangero J; Whitfield JB; Ahmad S; Buyske S; Menni C; Cadby G; Gordon-Larsen P; Lupoli S; Vandenput L; Kanoni S; Kumari M; Braga D; Feitosa MF; den Ruijter HM; Jukema W; Sung YJ; Bouchard C; Hallmans G; Thorand B; Abecasis GR; Karlsson M; de Craen AJM; Vitart V; Porteous DJ; Siemelink MA; Qi QB; Lobbens S; Uitterlinden AG; Kolovou G; Tanaka T; McKenzie CA; Lubke G; Kooperberg C; Snieder H; Zhao JH; Ahluwalia TS; Homuth G; Luan J; Cucca F; Renstrom F; Lyytikainen LP; Huffman JE; Teumer A; Swift AJ; Yengo L; Mangino M; Wareham NJ; Sattar N; Lakka TA; Kuusisto J; Buckley BM; Ngwa JS; Trompet S; Kilpelainen TO; Tremoli E; de Geus EJC; Pedersen O; Vohl MC; Juonala M; Cooper RS; Coggeshall S; Bruinenberg M

Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, ...

CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits

Cusi D; Franke L; Noukas M; Raitakari OT; Perola M; Kutalik Z; Sinisalo J; Reymond A; Koponen P; Loos RJF; Sapkota Y; Yaghootkar H; Oldehinkel AJ; Geller F; Lokki ML; Metspalu A; Chambers JC; Porcu E; Nolte IM; Wain LV; Jacquemont S; Strachan DP; Sparso T; Ang WQ; Kahonen M; Feitosa MF; Perls TT; Wood AR; Mannik K; Lundqvist A; Rissanen H; Salvi E; Snieder H; Palotie A; Bottinger EP; Venturini C; Lehtimaki T; Beaumont RN; Koskinen S; Wray NR; Hirschhorn J; Kriebel J; Mannisto S; Heid IM; Werge T; Shrine N; Hansen TF; Meitinger T; Beckmann JS; Lettre G; Schick U; Peters A; Deloukas P; Ruth KS; Newman AB; Wojczynski MK; Boers H; Lenzini P; Frayling TM; Nieminen M; Afaq S; Liu XP; Martin NG; Medland SE; Tyrrell J; Kristiansson K; Melbye M; Mattsson H; Christensen K; Porteous D; Feenstra B; Kooner JS; Muller-Nurasyid M; Magi R; Deelen P; Freathy RM; van der Most PJ; Salomaa V; Hayward C; Viikari JS; Schupf N; Nyholt DR; Winkler TW; Jones SE; Zhang WH; Spector TD; Havulinna AS; Lahti J; Bochud M; Eriksson JG; Rueger S; Province MA; Tobin MD; Weedon MN; Rivadeneira F; Vartiainen E; Tuke MA; Mangino M; Swertz MA; McDaid AF; Montgomery GW; Murray A; Rosengren A; Pennell C; Borodulin K; Mace A

There are few examples of robust associations between rare copy number variants (CNVs) and complex continuous human traits. Here we present a large-scale CNV association meta-analysis on anthropometric traits in up to ...

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Zhang WH; Wilsgaard T; Campbell H; Dimitriou M; Strawbridge RJ; North KE; Holmen O; Simino J; O'Connell JR; Deloukas P; Salomaa V; Richards M; Wild SH; Pankow JS; Oostra BA; Lorentzon M; Lehtimaki T; Benaglio P; Vohl MC; Kumari M; Vitart V; Rueger S; Eiriksdottir G; Lobbens S; Jordan JM; McCarthy MI; Hillege H; Nolte IM; Walker M; Vermeulen SH; Baldassarre D; Boehm BO; Waeber G; Alves AC; Chakravarti A; Uitterlinden AG; Huikuri HV; Rivadeneira F; Bruinenberg M; Walker RW; Magi R; Friedrich N; van Schoor NM; Kooner JS; Farrall M; Gyllensten U; Njolstad I; Bellis C; Stancakova A; Feitosa MF; Czajkowski J; Menni C; Pramstaller PP; Cusi D; Tsafantakis E; Pascoe L; Lind L; Eriksson J; Bakker SJL; Staessen JA; Bonnefond A; Merger S; Psaty BM; Jukema JW; Pilia MG; Vlachopoulou E; Cucca F; Kathiresan S; Thorsteinsdottir U; Hui J; Chines PS; de Craen AJM; Mantyselka P; Krarup NT; Boyd HA; Koskinen S; Froguel P; Loos RJF; Beilby J; Buchman AS; Gansevoort RT; Smit JH; van der Harst P; Kutalik Z; Rauramaa R; Jorgensen T; Scholtens S; Mahajan A; Gu YM; Boomsma DI; Pervjakova N; Bluher M; Leach IM; Cadby G; Waldenberger M; Musk AW; Renstrom F; Sarzynski MA; Fox CS; Neinast MD; Rotter JI; Hassinen M; van der Velde N; Tuomilehto J; Launer LJ; Liu YP; van Setten J; Tonjes A; Sorensen TIA; Palotie A; Langenberg C; Lindgren CM; Collins FS; Sung YJ; Kuh D; Lettre G; Heliovaara M; Stirrups K; Grarup N; Juonala M; Lahti J; Ferrucci L; Rice KM; Kaplan RC; Moll FL; Laakso M; Husemoen LL; Swift AJ; Tyrer JP; Clegg DJ; Ridker PM; Monda KL; Farmaki AE; Thorand B; Franks PW; Smith AV; Willenborg C; Rao DC; Bergman RN; Sennblad B; Liu YF; Maerz W; Justice AE; Illig T; Dedoussis G; Grassler J; Viikari JS; Koenig W; Bennett DA; Graff M; Jacobs KB; Rayner NW; Wennauer R; Willemsen G; Pedersen NL; Pers TH; Gudnason V; Zeggini E; Kaakinen M; Albrecht E; de Geus EJC; Hirschhorn JN; Rizzi F; Tachmazidou I; Eury E; Hu F; Schwarz PEH; Jalilzadeh S; Gottesman O; Grammer TB; Waite LL; Duan J; Raitakari OT; Stefansson K; Hayward C; Hartman CA; Schunkert H; Kolcic I; Kiemeney LALM; Mitchell BD; Teumer A; Gustafsson S; Ryan KA; Hall P; Goel A; Yu L; Tanaka T; Heard-Costa NL; Beckmann JS; Luben R; Franke L; Leander K; Volker U; Sanders AR; Jula A; Sattar N; Fischer K; Mohlke KL; Hovingh KG; Delgado G; Bergmann S; Spector TD; Lu YC; Linneberg A; Kittner SJ; Bouchard C; Broer L; Kilpelainen TO; Barcella M; Chen YDI; Bonnycastle LL; Vandenput L; van der Laan SW; Syvanen AC; Metspalu A; Koistinen HA; Ferreira T; Sinisalo J; McArdle WL; Boerwinkle E; Bonnet F; Knekt PB; Wong A; Jansen R; Lyssenko V; Seufferlein T; Lannfelt L; Muller-Nurasyid M; Hysi PG; Tan ST; Lokki ML; Heath AC; Morris AP; den Ruijter HM; Rioux JD; Sebert S; Zhao JH; Tremblay A; Hicks AA; Yerges-Armstrong LM; Bottinger EP; Lindstrom J; Vonk JM; Sengupta S; Montasser ME; de Groot LCPGM; Gorski M; Kahonen M; Gejman PV; Grallert H; Pouta A; Blangero J; Verweij N; De Jager PL; Absher D; Qi L; Ham AC; Pedersen O; Demirkan A; Groop LC; Ford I; Frau F; Thorleifsson G; Kinnunen L; Khaw KT; Strachan DP; Banasik K; Teslovich TM; Rudan I; Stefania B; Lotay V; Cole J; Bis JC; Barlassina C; Hutri-Kahonen N; Kleber ME; Sparso TH; Oldehinkel AJ; Perola M; Ahluwalia TS; Hattersley AT; Madden PAF; Hamsten A; Quertermous T; Wilson JF; Hengstenberg C; Ong KK; Berndt SI; Hastie N; Westra HJ; Salo P; Chambers JC; Tremoli E; Johansson A; Stringham HM; Trompet S; Boucher G; Kajantie E; Ingelsson E; Barata L; Chu S; Scharnagl H; Hottenga JJ; Ohlsson C; Glorioso N; Mannisto S; Gordon-Larsen P; Ahmad S; Karaleftheri M; Levinson DF; Hunter DJ; Fall T; Montgomery GW; de Faire U; Borecki IB; Kruger J; Stolk RP; Jaquish CE; de Bakker PIW; Pasterkamp G; Lagou V; Lanzani C; Karjalainen J; Silveira A; Henders AK; McKnight B; Saltevo J; Forouhi NG; Rice TK; Winkler TW; Hingorani A; Ehret GB; Milani L; Evans DA; Esko T; Boehnke M; Pichler I; Peters A; Mangino M; Eklund N; Bragg-Gresham JL; Lehne B; Cheng YC; Vollenweider P; Hveem K; Erdmann J; Muller G; Harris TB; Galesloot TE; Gieger C; Schlessinger D; Kratzer W; Kanoni S; Hernandez D; Gigante B; Shi JX; van Duijn CM; Hansen T; Magnusson PK; Abecasis GR; Asselbergs FW; Panoutsopoulou K; Wang SR; Assimes TL; Prokopenko I; Eriksson JG; Scott WR; Slagboom PE; Shuldiner AR; Cupples LA; Polasek O; Wallaschofski H; Boger CA; Heid IM; Rose LM; Claudi-Boehm S; Chasman DI; Rivolta C; Paternoster L; Wang ZM; van Dijk SC; Scott RA; Lakka TA; Mihailov E; Chiang CWK; Penninx BW; Enroth S; James AL; Kyriakou T; Volzke H; Medina-Gomez C; Dueker N; Feenstra B; Yengo L; Kovacs P; Verbeek ALM; Nelis M; Ribel-Madsen R; van Vliet-Ostaptchouk JV; Rankinen T; Steinthorsdottir V; Huffman JE; Kuusisto J; Swertz MA; Go AS; Melbye M; Geller F; Zillikens MC; Narisu N; Watkins H; Kivimaki M; Snieder H; Sanna S; Rheinberger M; Southam L; Haitjema S; Hofman A; Wright AF; Murray JC; Jackson AU; Bornstein SR; Perusse L; Stumvoll M; Widen E; Wareham NJ; White CC; Luan J; Uusitupa M; Gronberg H; Lo KS; Palmer LJ; Tardif JC; Martin NG; Barroso I; Andersson EA; Chanock SJ; Yang J; Nieminen MS; van der Most PJ

<p> Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body ...