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Non-HLA Gene Polymorphisms in the Pathogenesis of Type 1 Diabetes: Phase and Endotype Specific Effects
The non-HLA loci conferring susceptibility to type 1 diabetes determine approximately half of the genetic disease risk, and several of them have been shown to affect immune-cell or pancreatic beta-cell functions. A number ...
HLA-DR-DQ haplotypes and specificity of the initial autoantibody in islet specific autoimmunity
<p>Objective<br>We aimed to clarify the association of various HLA risk alleles with different types of autoantibodies initiating islet specific autoimmunity.</p><p>Methods<br>Follow-up cohorts from the Finnish Type 1 ...
Detection of enterovirus RNA in peripheral blood mononuclear cells correlates with the presence of the predisposing allele of the type 1 diabetes risk gene IFIH1 and with disease stage
<p><b>Aims/hypothesis</b> Enteroviral infection has been implicated consistently as a key environmental factor correlating with the appearance of autoimmunity and/or the presence of overt type 1 diabetes, in which pancreatic ...