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Childhood and long-term dietary calcium intake and adult cardiovascular risk in a population with high calcium intake
<p>Background & aims</p><p>The influence of dietary calcium intake in childhood on adult cardiovascular health is unknown, particularly in those with long-term high intake. To examine both linear and non-linear associations ...
Low serum adiponectin levels in childhood and adolescence predict increased intima-media thickness in adulthood. The Cardiovascular Risk in Young Finns Study
<p><b>Introduction:</b> Low adiponectin levels may predict the development of atherosclerosis. We examined the association of childhood adiponectin with preclinical carotid atherosclerosis that is defined as plaque and/or ...
Genome-wide association study of circulating interleukin 6 levels identifies novel loci
<p>Interleukin 6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease pathogenesis. We conducted a two-staged, discovery and replication meta genome-wide association study (GWAS) of circulating serum IL-6 levels comprising up to 67428 (n<sub>discovery</sub>=52654 and n<sub>replication</sub>=14774) individuals of European ancestry. The inverse variance fixed effects based discovery meta-analysis, followed by replication led to the identification of two independent loci, IL1F10/IL1RN rs6734238 on chromosome (Chr) 2q14, (P<sub>combined</sub>=1.8x10<sup>-11</sup>), HLA-DRB1/DRB5 rs660895 on Chr6p21 (P<sub>combined</sub>=1.5x10<sup>-10</sup>) in the combined meta-analyses of all samples. We also replicated the IL6R rs4537545 locus on Chr1q21 (P<sub>combined</sub>=1.2x10<sup>-122</sup>). Our study identifies novel loci for circulating IL-6 levels uncovering new immunological and inflammatory pathways that may influence IL-6 pathobiology.</p>...
The Role of Inflammatory Cytokines as Intermediates in the Pathway from Increased Adiposity to Disease
<p>Objective <br></p><p>This study aimed to investigate the role of cytokines as intermediates in the pathway from increased adiposity to disease.<br></p><p>Methods <br></p><p>BMI and circulating levels of up to 41 cytokines ...
Childhood exposure to parental smoking and life-course overweight and central obesity
<p><strong>Objective: </strong>To evaluate the association between childhood parental smoking exposure and the risk of overweight/obesity from childhood to adulthood.</p><p><strong>Methods: </strong>This study leverages ...
Sugar-Sweetened Beverage Consumption May Modify Associations Between Genetic Variants in the CHREBP (Carbohydrate Responsive Element Binding Protein) Locus and HDL-C (High-Density Lipoprotein Cholesterol) and Triglyceride Concentrations
<p>Background:<br>ChREBP (carbohydrate responsive element binding protein) is a transcription factor that responds to sugar consumption. Sugar-sweetened beverage (SSB) consumption and genetic variants in the CHREBP locus ...