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Aluminum fluoride-18 labeled folate enables in vivo detection of atherosclerotic plaque inflammation by positron emission tomography

Miikka Tarkia; Senthil Palani; Jarkko P. Hytönen; Pekka Saukko; Juhani Knuuti; Antti Saraste; Päivi Marjamäki; Heidi Liljenbäck; Harri Hakovirta; Xiang-Guo Li; Anne Roivainen; Philip S. Low; Seppo Ylä-Herttuala; Virva Saunavaara; Johanna M. U. Silvola; Jenni Virta; Saija Hurme; Qingshou Chen

Inflammation plays an important role in the development of atherosclerosis and its complications. Because the folate receptor beta (FR-beta) is selectively expressed on macrophages, an FR targeted imaging agent could be ...

Amyloid-Targeting PET Tracer [18F]Flutemetamol Accumulates in Atherosclerotic Plaques

Anne Roivainen; Johanna M.U. Silvola; Olli Eskola; Veronique Morisson-Iveson; Ella Hirani; Seppo Ylä-Herttuala; Sohvi Hörkkö; Antti Saraste; Heidi Liljenbäck; Sanna Hellberg; Harri Hakovirta; Juhani Knuuti; Pekka Saukko; Max Kiugel

<p>Atherosclerosis is characterized by the accumulation of oxidized lipids in the artery wall, which triggers an inflammatory response. Oxidized low-density lipoprotein (ox-LDL) presents amyloid-like structural properties, ...