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Effects of dipeptidyl peptidase 4 inhibition on inflammation in atherosclerosis: A 18F-fluorodeoxyglucose study of a mouse model of atherosclerosis and type 2 diabetes

Juhani Knuuti; Pirjo Nuutila; Mia Ståhle; Heidi Liljenbäck; Jenni Huusko; Jenni Virta; Sanna Hellberg; Seppo Ylä-Herttuala; Mirva Söderström; Johanna M.U. Silvola; Antti Saraste; Maria F. Gomez; Anne Roivainen

<p><strong>Background and aims: </strong>Dipeptidyl peptidase 4 (DPP-4) inhibitors have anti-inflammatory and atheroprotective effects. We evaluated the effects of the DPP-4 inhibitor linagliptin on atherosclerotic plaque ...

Amyloid-Targeting PET Tracer [18F]Flutemetamol Accumulates in Atherosclerotic Plaques

Anne Roivainen; Johanna M.U. Silvola; Olli Eskola; Veronique Morisson-Iveson; Ella Hirani; Seppo Ylä-Herttuala; Sohvi Hörkkö; Antti Saraste; Heidi Liljenbäck; Sanna Hellberg; Harri Hakovirta; Juhani Knuuti; Pekka Saukko; Max Kiugel

<p>Atherosclerosis is characterized by the accumulation of oxidized lipids in the artery wall, which triggers an inflammatory response. Oxidized low-density lipoprotein (ox-LDL) presents amyloid-like structural properties, ...