Hae

Aineistot 1-10 / 14

Relative Contribution of Blood Pressure in Childhood, Young- and Mid-Adulthood to Large Artery Stiffness in Mid-Adulthood

Pahkala K; Laitinen T; Hutri-Kähönen N; Wu FT; Raitakari OT; Sharman JE; Juonala M; Fraser BJ; Buscot MJ; Armstrong MK; Magnussen CG; Viikari JSA; Kahonen M; Meng YX

Background Blood pressure associates with arterial stiffness, but the contribution of blood pressure at different life stages is unclear. We examined the relative contribution of childhood, young- and mid-adulthood blood ...

Early cardiovascular structural and functional abnormalities as a guide to future morbid events

Raitakari OT; Koskinen JS

Association of Body Mass Index in Youth With Adult Cardiometabolic Risk

Wu FT; Magnussen CG; Laitinen TP; Buscot MJ; Viikari JSA; Kahonen M; Raitakari OT; Sabin MA; Pahkala K; Hutri-Kahonen N; Smith KJ; Juonala M

<div>Background: Whether long-term exposure to overweight or obesity from early life to adulthood has a detrimental influence on health outcomes is unknown. We aimed to investigate whether duration of overweight or obesity ...

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

Lyytikäinen LP; Kähönen M; Havulinna AS; Maan AC; Brody JA; Olesen M; Bis JC; Schramm K; Isaacs A; Rudan I; Yao J; Gögele M; De Grandi A; Ryan K; Shuldiner AR; Gustav Smith J; Kooperberg C; Van Duijvenboden S; Sinagra G; Benjamin EJ; Kerr KF; Felix SB; Cucca F; Lin HJ; Lin H; Campbell H; Thorolfsdottir RB; Stefansson K; Boutin T; Aeschbacher S; Ribeiro ALP; Arnar DO; Polasek O; Taylor KD; Warren HR; Nelson CP; Wilson JF; Lima-Costa MF; Meitinger T; Assa S; Rice K; Souza RP; Mei H; Levy D; Heckbert SR; Harris TB; Smith AV; Morris AP; Montasser ME; Lambiase PD; Lubitz SA; Mishra PP; Ntalla I; Raitakari OT; Benjamin Shoemaker M; Soliman EZ; Seyerle AA; Concas MP; Barnes CLK; Sotoodehnia N; Noordam R; Joshi PK; Haessler J; Kolcic I; Gudnason V; Jula A; Huang PL; Gasparini P; van Duijn CM; London B; Reiner AP; Völker U; Mook-Kanamori DO; Kääb S; Del Greco M F; Thorleifsson G; Lunetta KL; Cutler MJ; Ellinor PT; O'Connell JR; Spector TD; Newton-Cheh CH; van den Berg ME; Uitterlinden A; Weiss S; de Mutsert R; Dominiczak A; Conen D; Salomaa V; Gudbjartsson DF; Wouter Jukema J; Thériault S; Munroe PB; Nikus K; Launer LJ; Sulem P; Strauch K; Rotter JI; Mahajan A; Giedraitis V; Cranley JJ; Riaz MB; Barnes MR; Tarasov KV; Psaty BM; Guo X; Thorsteinsdottir U; Gogarten SM; Stricker BH; Sveinbjornsson G; Fuchsberger C; Arking DE; Correa A; Ramirez J; Caulfield MJ; Choi SH; Smith BH; Boerwinkle E; Peters U; Ingelsson E; Qian Y; Marten J; Risch L; Avery CL; Araujo NM; Weng LC; Sääksjärvi K; Lakatta EG; Porteous DJ; Foco L; Dörr M; Tucker NR; van de Vegte YJ; Macfarlane PW; Kors JA; Ehret GB; Mifsud B; Roden DM; Mangino M; Ford I; Jamshidi Y; Cartwright JH; Lind L; Yldau van der Ende M; Pramstaller PP; Verweij N; Pattaro C; Nadkarni GN; Biggs ML; Lehtimäki T; Murray AD; Laurie CC; Whitsel EA; Tinker A; Hayward C; Alonso A; Cook JP; Samani NJ; Wilson J; Preuss MH; Loos RJF; Roselli C; Holm H; van der Harst P; Hicks AA; Trompet S; Chaffin MD; Orini M; Padmanabhan S; Sundström J; Bottinger EP; Waldenberger M; Jackson RD; Rienstra M; Ulivi S; Müller-Nurasyid M; Stilp A; Fatkin D; Mononen N; Abdullah Said M; Tarazona-Santos E; Peters A; Hall AW; Lindgren CM; Ding J; Hutri-Kähönen N; Sinner MF

The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we ...

Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles

Winsvold BS; Sigurdardottir GR; Kahonen M; Ran C; Kurth T; Farkkila M; Belin AC; Gormley P; Sveinsson OA; Ripatti S; Hrafnsdottir MG; Magnusson SH; Widen E; Aromaa A; van Dijk KW; Rosendaal FR; Ullum H; Buring JE; de Boer I; Skogholt AH; Ikram MA; Banasik K; Hautakangas H; Hottenga JJ; Nyholt DR; Noordam R; Dichgans M; Thomas LF; Wessman M; Chalmer MA; van den Maagdenberg AMJM; Freilinger T; Olesen J; Kallela M; Thorgeirsson TE; Bjornsdottir A; Hveem K; Kogelman LJA; Zwart JA; Penninx BWJH; Raitakari OT; Stefansson K; Hansen TF; Burgdorf KS; Hagen K; Garbrielsen ME; Benner C; Johnsen MB; Pedersen OB; Harder AVE; Lighart L; Malik R; Ruotsalainen SE; Ghanbari M; Vijfhuizen LS; Kristoffersen ES; Lehtimaki T; Pelzer N; Ridker PM; Happola P; Jarvelin MR; Pirinen M; Chasman DI; Bjornsdottir G; Brumpton B; Terwindt GM; Boomsma DI; Erikstrup C; Stefansson H; Artto V; Palotie A

Genome-wide association analyses identify 123 susceptibility loci for migraine and implicate neurovascular mechanisms in its pathophysiology. Subtype analyses highlight risk loci specific for migraine with or without aura ...

Education leads to a more physically active lifestyle: Evidence based on Mendelian randomization

Hirvensalo M; Tammelin TH; Pahkala K; Lehtimäki T; Kari JT; Böckerman P; Pehkonen J; Viinikainen J; Raitakari OT; Pitkänen N

Physical inactivity is a major health risk worldwide. Observational studies suggest that higher education is positively related to physical activity, but it is not clear whether this relationship constitutes a causal effect. ...

Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

Yang Q; Felix JF; O'Connell J; Sveinbjornsson G; Schulz CA; Lieb W; Guilianini F; Ghasemi S; Wilson JF; Preuss MH; Palmer ND; Willer CJ; Hartman CA; Kramer BK; Foo VHX; Bansal N; Hung AM; Thorsteinsdottir U; Parsa A; Yu Z; Pirastu N; Gordon SD; Verweij N; Porteous DJ; Rice KM; Stefansson K; Magnusson PKE; Kuusisto J; Hveem K; Chai JF; Stringham HM; Waeber G; Campbell A; Phillips LS; Tin A; Heng CK; Franke A; Spedicati B; Gunther F; Huang W; Christensen K; Mishra PP; Langefeld CD; Morris AP; Okada Y; Burkhardt R; Ning B; Ciullo M; Schottker B; Schmidt R; Tao R; Pontali G; Ehret G; Friedlander Y; Nikus K; Girotto G; Tayo B; Giedraitis V; Stanzick KJ; Jakobsdottir J; Holm H; Gao H; Oldehinkel AJ; Vanderwerff BR; Orho-Melander M; Mychaleckyj JC; Kronenberg F; Loos RJF; Wallentin L; Citterio L; Lucae S; Rasheed H; Wang CL; Vaccargiu S; Bottinger EP; Salomaa V; Kahonen M; Scholz M; Waldenberger M; Bochud M; Freitag-Wolf S; Morgan A; Milaneschi Y; Tham YC; Kooner JS; O'Donoghue ML; Haller T; Stark KJ; Kovacs P; Daw EW; Korner A; Kerr SM; Salvi E; Sedaghat S; Melander O; Miliku K; Zonderman AB; Svensson PO; Polasek O; Kammerer CM; Rabelink TJ; Rudan I; Marz W; Rivadeneira F; Kastarinen M; Teumer A; Kramer H; Gaziano JM; de Vries APJ; Tan NYQ; Lim SC; Kirsten H; Feresin A; Noordam R; Thio CHL; Rossing P; Spracklen CN; Cook JP; Montgomery GW; Brumpton B; Gasparini P; Magi R; Patil SB; Lanzani C; Raitakari OT; Hamet P; Metspalu A; Smith AV; Waterworth DM; Manunta P; Reilly DF; Jung B; Martins J; Rizzi F; Nolte IM; Rowan BX; Vogelezang S; Graham SE; Heid IM; Pramstaller PP; Jaddoe VWV; Penninx BWJH; Gorski M; Coresh J; Feitosa MF; Koenig W; Boehnke M; Kuokkanen M; Banas B; Marten J; Rotter JI; Ikram MA; Lehtimaki T; Lyytikainen LP; Strauch K; Boutin TS; Gudbjartsson DF; Campbell H; Sim RZH; Wang YX; Tremblay J; Podgornaia AI; Catamo E; Lee JJM; Vitart V; Nalls MA; Xu J; Pistis G; Volker U; Peters A; Shaffer CM; Arnlov J; Delgado GE; Ryan KA; Mook-Kanamori DO; Rueedi R; Correa A; Divers J; van der Most PJ; Cocca M; Tai ES; Bergmann S; Martin NG; Hallan S; Launer LJ; Josyula NS; Lukas MA; Mononen N; Horn K; van der Harst P; Stumvoll M; Perola M; Chambers JC; Carroll RJ; Francescatto M; Raffield LM; Hayward C; Chee ML; Khor CC; Ahluwalia TS; Gansevoort RT; Snieder H; Brenner H; Biggs ML; Halbritter J; Hwang SJ; Padmanabhan S; Tonjes A; Chu AY; Cheng CY; Pattaro C; Thomas LF; Klaric L; Endlich K; Nutile T; Meitinger T; Taylor KD; De Grandi A; Laakso M; White HD; Bakker SJL; Kottgen A; Eckardt KU; Yerges-Armstrong LM; Sieber KB; Wei WB; Schmidt H; La Bianca M; Kanai M; Yasuda M; Ising M; Dehghan A; Kavousi M; Hutri-Kahonen N; Lindgren CM; Loeffler M; Hoppmann A; Dittrich K; Wuttke M; Jonas JB; Gieger C; Rosenkranz AR; Matsuda K; Guo F; Winkler TW; Mascalzoni D; Mahajan A; Kamatani Y; Dorajoo R; Gao X; Boerwinkle E; Joshi PK; Sabanayagam C; Evans MK; Psaty BM; Cusi D; Hofer E; Ruggiero D; Li Y; Sim XL; Boger CA; Toniolo D; Freedman BI; Piratsu M; Smith BH; Concas MP; Nadkarni GN; Robinson-Cohen C; Hicks AA; Felicita SC; Mohlke KL; Elliott P; Bergler T; Kleber ME; Gudnason V; Biino G; Liu JJ; Fuchsberger C; Esko T; Zhang WH; Kubo M; Asvold BO; Schupf N; Vollenweider P; Thiery J; Wong TY; van Dam RM; Ponte B; Ghanbari M; Wojczynski MK; Li HT; Whitfield JB; Ridker PM; Tzoulaki I; Teren A; Nauck M; Li M; Ho K; Lind L; Kiess W; de Borst MH; Akiyama M; Gogele M; Olafsson I; Chasman DI; Corre T; Province MA; Sulem P; Czamara D; Lange LA; de Mutsert R; Pendergrass SA; Devuyst O

A large-scale GWAS provides insight on diabetes-dependent genetic effects on the glomerular filtration rate, a common metric to monitor kidney health in disease.Reduced glomerular filtration rate (GFR) can progress to ...

Exposure to parental smoking and cardiac structure and function in adulthood: the Cardiovascular Risk in Young Finns Study

Ruohonen S; Pahkala K; Magnussen CG; Burgner DP; Laitinen TP; Tossavainen P; Kahonen M; Nuotio J; Taittonen L; Pihlman J; Jokinen E; Hutri-Kahonen N; Rovio S; Raitakari OT; Viikari JSA; Juonala M

Background and aims: The relationship between childhood tobacco smoke exposure and cardiac structure and function in midlife is unclear. We investigated the association between parental smoking with ...

Tracking and Changes in Daily Step Counts among Finnish Adults

Rovio SP; Hirvensalo M; Tammelin TH; Pahkala K; Hakonen H; Raitakari OT; Kulmala J; Hutri-Kahonen N; Yang XL; Kukko T

Purpose This study aimed to investigate the tracking and changes of steps per day in adults and their determinants over 13 yr. Methods A total of 2195 subjects (1236 women) 30-45 yr of age were randomly recruited from the ...

DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases

Brenner H; Kasela S; Sotoodehnia N; Smith AK; Relton C; Doerr M; Wielscher M; Robinson O; Psaty BM; Baccarelli AA; Selvin E; Deloukas P; van Meurs JBJ; Marouli E; Mustafa R; Ghanbari M; Bell JT; Kahonen M; Krogh V; Teumer A; Levy D; Waldenberger M; Chambers JC; Brody JA; van der Harst P; Panico S; Colicino E; Hurme MA; Bis JC; Peters A; Guan WH; Karhunen V; Chen W; Kottgen A; Torres MA; Matullo G; Cardona A; Lehne B; Bodinier B; Nauck M; Tumino R; Fiorito G; Dehghan A; Verweij N; Schlosser P; Iacoviello L; Marioni RE; Kuehnel B; Graf-Schindler J; Kooner JS; Beekman M; Fisher K; Koenig W; Chadeau-Hyam M; Milani L; Tzala E; Vineis P; Waite LL; Lehtimaki T; Jarvelin MR; Conneely KN; Farlik M; Heijmans BT; Palaniswamy S; Deary IJ; Mandaviya PR; Rathmann W; Miller AH; Gao X; Herzig KH; Ong KK; Elliott P; Walton E; Cugliari G; Joehanes R; Zhang Y; Raitakari OT; Boerwinkle E; Wilson R; Loh M; Xia YJ; Grabe HJ; Tsai PC; Li SX; Mishra PP; Weninger W; Zhang T; Tanaka T; Sacerdote C

Chronic inflammation, marked by C-reactive protein, has been associated with changes in methylation, but the causal relationship is unclear. Here, the authors perform a Epigenome-wide association meta-analysis for C-reactive ...