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Dose-area product ratio in external small-beam radiotherapy: beam shape, size and energy dependencies in clinical photon beams
In small-field radiotherapy (RT), a significant challenge is to define the amount of radiation dose absorbed in the patient where the quality of the beam has to be measured with high accuracy. The properties of a proposed ...
Rapid detection of functional gene polymorphisms of TLRs and IL-17 using high resolution melting analysis
Genetic variations in toll-like receptors (TLRs) and IL-17A have been widely connected to different diseases. Associations between susceptibility and resistance to different infections and single nucleotide polymorphisms ...
Polygenic Hyperlipidemias and Coronary Artery Disease Risk
Background:<div>Hyperlipidemia is a highly heritable risk factor for coronary artery disease (CAD). While monogenic familial hypercholesterolemia associates with severely increased CAD risk, it remains less clear to what ...
A novel processing-based classification and conventional food grouping to estimate milk product consumption in Finnish children
<p>As more information is needed about the health aspects of milk processing; we classified milk products based on their homogenisation and heat-treatment history in the following inclusive classes: (i) homogenised, (ii) ...
Reversibility of myocardial metabolism and remodelling in morbidly obese patients 6 months after bariatric surgery
<h3>Abstract</h3><div><h4>AIMS: </h4><p>To study myocardial substrate uptake, structure and function, before and after bariatric surgery, to clarify the interaction between myocardial metabolism and cardiac remodelling in ...
Homozygous loss-of-function mutations in SLC26A7 cause goitrous congenital hypothyroidism
Defects in genes mediating thyroid hormone biosynthesis result in dyshormonogenic congenital hypothyroidism (CH). Here, we report homozygous truncating mutations in SLC26A7 in 6 unrelated families with goitrous CH and show ...