Hae
Aineistot 1-10 / 23
SimPhospho: a software tool enabling confident phosphosite assignment
Motivation: Mass spectrometry combined with enrichment strategies for phosphorylated peptides has been successfully employed for two decades to identify sites of phosphorylation. However, unambiguous phosphosite assignment ...
Protein synthesis is suppressed in sporadic and familial Parkinson's disease by LRRK2
Gain of function LRRK2-G2019S is the most frequent mutation found in familial and sporadic Parkinson's disease. It is expected therefore that understanding the cellular function of LRRK2 will provide insight on the ...
Serum Proteomic Profiling to Identify Biomarkers of Premature Carotid Atherosclerosis
<p>To evaluate the presence of serum protein biomarkers associated with the early phases of formation of carotid atherosclerotic plaques, label-free quantitative proteomics analyses were made for serum samples collected ...
PASI: A novel pathway method to identify delicate group effects
Pathway analysis is a common approach in diverse biomedical studies, yet the currently-available pathway tools do not typically support the increasingly popular personalized analyses. Another weakness of the currently-available ...
A systematic evaluation of normalization methods in quantitative label-free proteomics
<p>To date, mass spectrometry (MS) data remain inherently biased as a result of reasons ranging from sample handling to differences caused by the instrumentation. Normalization is the process that aims to account for the ...
CIP2A Constrains Th17 Differentiation by Modulating STAT3 Signaling
Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A) is an oncogene and a potential cancer therapy target protein. Accordingly, a better understanding of the physiological function of CIP2A, especially in the context of ...
Likelihood contrasts: a machine learning algorithm for binary classification of longitudinal data
<p>Machine learning methods have gained increased popularity in biomedical research during the recent years. However, very few of them support the analysis of longitudinal data, where several samples are collected from an ...
A predictive model of overall survival in patients with metastatic castration-resistant prostate cancer
<p>Metastatic castration resistant prostate cancer (mCRPC) is one of the most common cancers with a poor prognosis. To improve prognostic models of mCRPC, the Dialogue for Reverse Engineering Assessments and Methods (DREAM) ...
MASTL promotes cell contractility and motility through kinase-independent signaling
Microtubule-associated serine/threonine-protein kinase-like (MASTL) is a mitosis-accelerating kinase with emerging roles in cancer progression. However, possible cell cycle-independent mechanisms behind its oncogenicity ...