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Receptor tyrosine kinase profiling of ischemic heart identifies ROR1 as a potential therapeutic target
BackgroundReceptor tyrosine kinases (RTK) are potential targets for the treatment of ischemic heart disease. The human RTK family consists of 55 members, most of which have not yet been characterized for expression or ...
68Ga-DOTA-E[c(RGDfK)]2 Positron Emission Tomography Imaging of SHARPIN-Regulated Integrin Activity in Mice
Sharpincpdm mice demonstrated increased integrin activity and vascularization in B16-F10-luc melanoma tumors, as demonstrated by RGD-based in vivo PET imaging. These data indicate that SHARPIN, a protein previously associated ...
Transcytosis route mediates rapid delivery of intact antibodies to draining lymph nodes
<p>Lymph nodes (LNs) filter lymph to mount effective immune responses. Small soluble lymph-borne molecules from the periphery enter the draining LNs via a reticular conduit system. Intact antibodies and other larger ...
DNA methylation and Transcriptome Changes Associated with Cisplatin Resistance in Ovarian Cancer
<p>
</p><p>High-grade serous
ovarian cancer is the most common ovarian cancer type. Although the combination
of surgery and platinum-taxane chemotherapy provide an effective treatment,
drug resistance frequently ...
Identification of Predictive ERBB Mutations by Leveraging Publicly Available Cell Line Databases
While targeted therapies can be effective for a subgroup of patients, identification of individuals who benefit from the treatments is challenging. At the same time, the predictive significance of the vast majority of the ...
Effects of Different Exercise Training Protocols on Gene Expression of Rac1 and PAK1 in Healthy Rat Fast- and Slow-Type Muscles
Purpose Rac1 and its downstream target PAK1 are novel regulators of insulin and exercise-induced glucose uptake in skeletal muscle. However, it is not yet understood how different training intensities affect the expression ...
Structural Basis for the Functional Changes by EGFR Exon 20 Insertion Mutations
<div><b>Simple Summary</b></div><div>Non-small cell lung cancer (NSCLC) is the most common type of lung cancer that claims the lives of many worldwide. Activating mutations occurring on the epidermal growth factor receptor ...
An unbiased in vitro screen for activating epidermal growth factor receptor mutations
Cancer tissues harbor thousands of mutations, and a given oncogene may
be mutated at hundreds of sites. Yet, only a few of these mutations have
been functionally tested. Here, we describe an unbiased platform for
the ...
Systemic Blockade of Clever-1 Elicits Lymphocyte Activation Alongside Checkpoint Molecule Downregulation in Patients with Solid Tumors: Results from a Phase I/II Clinical Trial
<p>Purpose:<br>Macrophages are critical in driving an immunosuppressive tumor microenvironment that counteracts the efficacy of T-cell–targeting therapies. Thus, agents able to reprogram macrophages toward a proinflammatory ...