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Distinct Patterns in Human Milk Microbiota and Fatty Acid Profiles Across Specific Geographic Locations
Breast feeding results in long term health benefits in the prevention of communicable and non-communicable diseases at both individual and population levels. Geographical location directly impacts the composition of breast ...
Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-κB Signaling
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SHANK-associated RH domain interactor (SHARPIN) inhibits integrins through interaction with the integrin α-subunit. In addition, SHARPIN enhances nuclear factor-kappaB (NF-κB) activity as a component of ...
A Negative Feedback Loop Regulates Integrin Inactivation and Promotes Neutrophil Recruitment to Inflammatory Sites
Neutrophils are abundant circulating leukocytes that are rapidly recruited to sites of inflammation in an integrin-dependent fashion. Contrasting with the well-characterized regulation of integrin activation, mechanisms ...
Fluctuation-Based Super-Resolution Traction Force Microscopy
Cellular mechanics play a crucial role in tissue homeostasis and are often misregulated in disease. Traction force microscopy is one of the key methods that has enabled researchers to study fundamental aspects of mechanobiology; ...
Integrin Binding Dynamics Modulate Ligand-Specific Mechanosensing in Mammary Gland Fibroblasts
<p>The link between integrin activity regulation and cellular mechanosensing of tissue rigidity, especially on different extracellular matrix ligands, remains poorly understood. Here, we find that primary mouse mammary ...
A Strong Contractile Actin Fence and Large Adhesions Direct Human Pluripotent Colony Morphology and Adhesion
<p>Cell-type-specific functions and identity are tightly regulated by
interactions between the cell cytoskeleton and the extracellular matrix
(ECM). Human pluripotent stem cells (hPSCs) have ultimate
differentiation ...
Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling
Cell-extracellular matrix (ECM) adhesion is a fundamental requirement for multicellular existence due to roles in positioning, proliferation and differentiation. Phosphorylation plays a major role in adhesion signalling; ...