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Early suppression of immune response pathways characterizes children with prediabetes in genome-wide gene expression profiling
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Type 1 diabetes (T1D) is caused by autoimmune destruction of insulin-producing pancreatic p cells in the islets of Langerhans. Although defects in various T cell subsets have been linked to the disease pathogenesis, ...
Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-κB Signaling
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SHANK-associated RH domain interactor (SHARPIN) inhibits integrins through interaction with the integrin α-subunit. In addition, SHARPIN enhances nuclear factor-kappaB (NF-κB) activity as a component of ...
Early fecal microbiota composition in children who later develop celiac disease and associated autoimmunity
<p>Objectives: Several studies have reported that the intestinal microbiota composition of celiac disease (CD) patients differs from healthy individuals. The possible role of gut microbiota in the pathogenesis of the disease ...
Gut Microbiota Richness and Composition and Dietary Intake of Overweight Pregnant Women Are Related to Serum Zonulin Concentration, a Marker for Intestinal Permeability
Background: Increased intestinal permeability may precede adverse metabolic conditions. The extent to which the composition of the gut microbiota and diet contribute to intestinal permeability during pregnancy is ...
Data-Independent Acquisition Mass Spectrometry in Metaproteomics of Gut Microbiota—Implementation and Computational Analysis
<p>Metagenomic approaches focus on
taxonomy or gene annotation but lack power in defining functionality of gut
microbiota. Therefore, metaproteomics approaches have been introduced to
overcome this limitation. However, ...
Comparative analysis of human and mouse transcriptomes of Th17 cell priming
Uncontrolled Th17 cell activity is associated with cancer and autoimmune and inflammatory diseases. To validate the potential relevance of mouse models of targeting the Th17 pathway in human diseases we used RNA sequencing ...
SHARPIN is an endogenous inhibitor of beta 1-integrin activation
Regulated activation of integrins is critical for cell adhesion, motility and tissue homeostasis. Talin and kindlins activate beta 1-integrins, but the counteracting inhibiting mechanisms are poorly defined. We identified ...
Peritoneal Cavity is a Route for Gut-Derived Microbial Signals to Promote Autoimmunity in Non-Obese Diabetic Mice
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Macrophages play a crucial role in innate immune reactions, and Peritoneal Macrophages (PMs) guard the sterility of this compartment mainly against microbial threat from the gut. Type-1 Diabetes (T1D) is an autoimmune ...