Hae
Aineistot 1-10 / 134
Genome sequences of RIGVIR oncolytic virotherapy virus and five other echovirus 7 isolates
<p>We report here the nearly complete Illumina-sequenced consensus genome sequences of six isolates of echovirus 7 (E7), including oncolytic virotherapy virus RIGVIR and the Wallace prototype. Amino acid identities within ...
Atopic asthma after rhinovirus-induced wheezing is associated with DNA methylation change in the SMAD3 gene promoter
<p>Children with rhinovirus-induced severe early wheezing have an increased risk of developing asthma later in life. The exact molecular mechanisms for this association are still mostly unknown. To identify potential changes ...
Sex-Dependent Improvement in Survival of Parkinson's Disease Patients
Background Advances in the treatment of Parkinson's disease (PD) and changes in general life expectancy may have improved survival in patients with PD.Objective The objective of this study was to investigate recent trends ...
Early Detection of Peripheral Blood Cell Signature in Children Developing Beta-Cell Autoimmunity at a Young Age
<p>The appearance of Type 1 diabetes (T1D)-associated autoantibodies is the
first and only measurable parameter to predict progression toward T1D
in genetically susceptible individuals. However, autoantibodies indicate
...
Receptor tyrosine kinase profiling of ischemic heart identifies ROR1 as a potential therapeutic target
BackgroundReceptor tyrosine kinases (RTK) are potential targets for the treatment of ischemic heart disease. The human RTK family consists of 55 members, most of which have not yet been characterized for expression or ...
RepViz: A replicate-driven R tool for visualizing genomic regions
<p>Objective: Visualization of sequencing data is an integral part of genomic data analysis. Although there are several
tools to visualize sequencing data on genomic regions, they do not ofer user-friendly ways to view ...
Cisplatin overcomes radiotherapy resistance in OCT4-expressing head and neck squamous cell carcinoma
<p><strong>Objectives: </strong>Cisplatin is combined with radiotherapy for advanced head and neck squamous cell carcinoma (HNSCC). While providing a beneficial effect on survival, it also causes side effects and thus is ...
A systematic comparison of FOSL1, FOSL2 and BATF-mediated transcriptional regulation during early human Th17 differentiation
Th17 cells are essential for protection against extracellular pathogens, but their aberrant activity can cause autoimmunity. Molecular mechanisms that dictate Th17 cell-differentiation have been extensively studied using ...
Hypoxia-inducible factor (HIF)-prolyl hydroxylase 3 (PHD3) maintains high HIF2A mRNA levels in clear cell renal cell carcinoma
Most clear cell renal cell carcinomas (ccRCCs) have inactivation of the von Hippel-Lindau tumor suppressor protein (pVHL), resulting in the accumulation of hypoxia-inducible factor -subunits (HIF-) and their downstream ...
Early-life exposure to perfluorinated alkyl substances modulates lipid metabolism in progression to celiac disease
<p>Celiac disease (CD) is a systemic immune-mediated disorder with increased frequency in the developed countries over the last decades implicating the potential causal role of various environmental triggers in addition ...