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Plasma cell-free DNA methylation marks for episodic memory impairment: a pilot twin study
<p>Decline in episodic memory performance usually causes the first clinical symptoms of Alzheimer’s disease. At present, Alzheimer’s disease can only be diagnosed at a very late stage when neurodegeneration and cognitive ...
DNA methylation and Transcriptome Changes Associated with Cisplatin Resistance in Ovarian Cancer
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</p><p>High-grade serous
ovarian cancer is the most common ovarian cancer type. Although the combination
of surgery and platinum-taxane chemotherapy provide an effective treatment,
drug resistance frequently ...
RNA Polymerase III Subunit POLR3G Regulates Specific Subsets of PolyA+ and SmallRNA Transcriptomes and Splicing in Human Pluripotent Stem Cells
<p>POLR3G is expressed at high levels in human pluripotent stem cells
(hPSCs) and is required for maintenance of stem cell state through
mechanisms not known in detail. To explore how POLR3G regulates stem
cell state, ...
Umbilical cord blood DNA methylation in children who later develop type 1 diabetes
<p><strong>Aims/hypothesis:</strong> Distinct DNA methylation patterns have recently been observed to precede type 1 diabetes in whole blood collected from young children. Our aim was to determine whether perinatal DNA ...
Early fecal microbiota composition in children who later develop celiac disease and associated autoimmunity
<p>Objectives: Several studies have reported that the intestinal microbiota composition of celiac disease (CD) patients differs from healthy individuals. The possible role of gut microbiota in the pathogenesis of the disease ...
A comparative evaluation of software for the analysis of liquid chromatography-tandem mass spectrometry data from isotope coded affinity tag experiments.
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The options available for processing quantitative data from isotope coded affinity tag (ICAT) experiments have mostly been confined to software specific to the instrument of acquisition. However, recent developments ...
PolyAlign –A versatile LC-MS data alignment tool for landmark-selected and automated use
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We present a versatile user-friendly software tool, PolyAlign, for the alignment of multiple LC-MS signal maps with the option of manual landmark setting or automated alignment. One of the spectral images is selected ...
Methylome Analysis of Human Bone Marrow MSCs Reveals Extensive Age- and Culture-Induced Changes at Distal Regulatory Elements
<p>Human bone marrow stromal cells, or mesenchymal stem cells (BM-MSCs), need expansion prior to use as cell-based therapies in immunological and tissue repair applications. Aging and expansion of BM-MSCs induce epigenetic ...