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Receptor tyrosine kinase profiling of ischemic heart identifies ROR1 as a potential therapeutic target
BackgroundReceptor tyrosine kinases (RTK) are potential targets for the treatment of ischemic heart disease. The human RTK family consists of 55 members, most of which have not yet been characterized for expression or ...
Correlation between 18F-1-amino-3-fluorocyclobutane-1-carboxylic acid (18F-fluciclovine) uptake and expression of alanine-serine-cysteine-transporter 2 (ASCT2) and L-type amino acid transporter 1 (LAT1) in primary prostate cancer
<p>Purpose: To evaluate the expression of alanine-serine-cysteine-transporter 2 (ASCT2) and L-type amino acid transporter1 (LAT1) in prostate cancer (PCa) and their impact on uptake of F-18-1-amino-3-fluorocyclobutane-1-carboxylic ...
Estimation of optimal number of gates in dual gated F-18-FDG cardiac PET
Gating of positron emission tomography images has been shown to reduce the motion effects, especially when imaging small targets, such as coronary plaques. However, the selection of optimal number of gates for gating remains ...
Predicting the Need for Biopsy to Detect Clinically Significant Prostate Cancer in Patients with a Magnetic Resonance Imaging–detected Prostate Imaging Reporting and Data System/Likert ≥3 Lesion: Development and Multinational External Validation of the Imperial Rapid Access to Prostate Imaging and Diagnosis Risk Score
<p><strong>Background</strong>: Although multiparametric magnetic resonance imaging (MRI) has high<br>sensitivity, its lower specificity leads to a high prevalence of false-positive lesions requir-<br>ing biopsy.<br><str ...
Uusia työkaluja paikallisesti edenneen ja etäpesäkkeisen eturauhassyövän lääkehoitoon
<p>Eturauhassyöpä on miehillä tavallisimmin todettu syöpä ja miesten toiseksi yleisin syöpäkuolemien aiheuttaja Suomessa. Levinneen eturauhassyövän lääkehoidossa keskeistä on androgeenireseptorin toiminnan estäminen ...
Immunological tumor status may predict response to neoadjuvant chemotherapy and outcome after radical cystectomy in bladder cancer
Bladder cancer (BC) is the ninth most common cancer worldwide. Radical cystectomy (RC) with neoadjuvant chemotherapy (NAC) is recommended for muscle-invasive BC. The challenge of the neoadjuvant approach relates to challenges ...
Human Metaplastic Breast Carcinoma and Decorin
<p>Metaplastic breast carcinoma (MBC) is a rare subtype of invasive breast
cancer and has poor prognosis. In general, cancers are heterogeneous
cellular masses comprised of different cell types and their
extracellular ...
Morbid obesity and type 2 diabetes alter intestinal fatty acid uptake and blood flow
<p>Aims: Bariatric surgery is the most effective treatment to tackle morbid obesity and type 2 diabetes, but the mechanisms of action are still unclear. The objective of this study was to investigate the effects of bariatric ...
A three-feature prediction model for metastasis-free survival after surgery of localized clear cell renal cell carcinoma
After surgery of localized renal cell carcinoma, over 20% of the patients will develop distant metastases. Our aim was to develop an easy-to-use prognostic model for predicting metastasis-free survival after radical or ...