Hae
Aineistot 1-10 / 144
Insights into disseminated MS brain pathology with multimodal diffusion tensor and PET imaging
<div>Objective To evaluate in vivo the co-occurrence of microglial activation and microstructural white matter (WM) damage in the MS brain and to examine their association with clinical disability.</div><div>Methods 18-kDa ...
Efficacy and safety outcomes in vitamin D supplement users in the fingolimod phase 3 trials
<h4>BACKGROUND:</h4><p>Low serum levels of 25-hydroxyvitamin D have been associated with worse outcomes in multiple sclerosis (MS) patients treated with interferon-beta. Association of vitamin D nutrition on the outcomes ...
Association between microglial activation and serum kynurenine pathway metabolites in multiple sclerosis patients
<p>Background<br></p><p>Microglial activation associates with MS progression but it is unclear what drives their persistent pro-inflammatory state. Metabolites of the kynurenine pathway (KP), the main metabolism route of ...
Burden of non-motor symptoms in unclear parkinsonism and tremor: A study with [I-123]FP-CIT SPECT
Background: Non-motor symptoms (NMSs) are clearly more prevalent in Parkinson's disease (PD) patients compared to healthy individuals. However, NMSs are also common in the elderly and other neurological conditions, and ...
Terveydentila- ja toimintakykymittareiden hyödyntäminen lääkehoidon toteutuksessa iäkkäiden kotihoidossa
<p>Johdanto: Iäkkäiden kotihoidon asiakkaiden terveydentilaa ja toimintakykyä arvioidaan säännöllisesti<br>erilaisin mittarein. Tässä tutkimuksessa tutkittiin, mitä terveydentila- ja toimintakykymittareita on käytössä ja ...
Sex-Dependent Improvement in Survival of Parkinson's Disease Patients
Background Advances in the treatment of Parkinson's disease (PD) and changes in general life expectancy may have improved survival in patients with PD.Objective The objective of this study was to investigate recent trends ...
Cessation of anti-VLA-4 therapy in a focal rat model of multiple sclerosis causes an increase in neuroinflammation
BackgroundPositron emission tomography (PET) can be used for in vivo evaluation of the pathology associated with multiple sclerosis. We investigated the use of longitudinal PET imaging and the 18-kDa translocator protein ...
Potential of heart fatty-acid binding protein, neurofilament light, interleukin-10 and S100 calcium-binding protein B in the acute diagnostics and severity assessment of traumatic brain injury
<p><strong>Background: </strong>There is substantial interest in blood biomarkers as fast and objective diagnostic tools for traumatic brain injury (TBI) in the acute setting.</p><p><strong>Methods: </strong>Adult patients ...
Positron emission tomography imaging in evaluation of MS pathology in vivo
<p>Positron emission tomography (PET) gives an opportunity to quantitate
the expression of specific molecular targets in vivo and longitudinally
in brain and thus enhances our possibilities to understand and follow ...
Seasonal variation in the brain μ-opioid receptor availability
<p>Seasonal rhythms influence emotion and sociability. The brain μ-opioid receptor (MOR) system modulates a multitude of seasonally varying socioemotional functions, but its seasonal variation remains elusive with no ...