Hae

Aineistot 1-10 / 26

Seasonal variation in the brain μ-opioid receptor availability

Roivainen Anne; Sun Lihua; Nummenmaa Lauri; Honkaniemi Aake; Nuutila Pirjo; Scheinin Harry; Hietala Jarmo; Kalliokoski Kari; Yatkin Emrah; Tang Jing; Isojärvi Janne; Eerola Kim; Hirvonen Jussi; Savontaus Eriika; Kantonen Tatu; Virta Jenni; Rinne Juha O; Helin Semi; Karjalainen Tomi; Liljenbäck Heidi; Kaasinen Valtteri

<p>Seasonal rhythms influence emotion and sociability. The brain μ-opioid receptor (MOR) system modulates a multitude of seasonally varying socioemotional functions, but its seasonal variation remains elusive with no ...

Circulating Docosahexaenoic Acid Associates with Insulin-Dependent Skeletal Muscle and Whole Body Glucose Uptake in OlderWomen Born from Normal Weight Mothers

Pirjo Nuutila; Marco Bucci; Patricia Iozzo; Johan G. Eriksson; Robert M. Badeau; Miikka-Juhani Honka

Background: Obesity among pregnant women is common, and their offspring are predisposed to obesity, insulin resistance, and diabetes. The circulating metabolites that are related to insulin resistance and are associated ...

Diffusion weighted imaging of prostate cancer xenografts: comparison of bayesian modeling and independent least squares fitting

Matti Poutanen; Ivan Jambor; Anne Roivainen; Hanne Hakkarainen; Hannu Juhani Aronen; Harri Merisaari; Parisa Movahedi; Timo Liimatainen; Heidi Liljenbäck; Heikki Minn; Helena Virtanen

18-kDa translocator protein ligand 18F-FEMPA: Biodistribution and uptake into atherosclerotic plaques in mice

Heinrich T; Savisto N; Roivainen A; Saraste A.; Hakovirta H; Vollmer S; Lehmann L; Knuuti J; Thiele A; Liljenbäck H; Kiugel M; Silvola JM; Hellberg S; Ylä-Herttuala S; Laine VJ; Li XG

<p>18F-FEMPA shows rapid blood clearance and uptake in the mouse aorta. Uptake in atherosclerotic plaques correlated with the amount of macrophages, but did not exceed that in the normal vessel wall.<br /></p>

Systemic Dosing of Thymosin Beta 4 before and after Ischemia Does Not Attenuate Global Myocardial Ischemia-Reperfusion Injury in Pigs

Knuuti J; Tarkia M; Jalkanen J; Koskenvuo J; Savo M; Kentala R; Savunen T; Malmberg M; Helenius M; Saraste A; Alastalo TP; Taimen P; Hynninen VV; Ruohonen S; Stark CKJ; Vahasilta T

The use of cardiopulmonary bypass (CPB) and aortic cross-clamping causes myocardial ischemia-reperfusion injury (I-RI) and can lead to reduced postoperative cardiac function. We investigated whether this injury could be ...

Rare protein-altering variants in ANGPTL7 lower intraocular pressure and protect against glaucoma

Palotie Aarno; Havulinna Aki S; Venkataraman Guhan; Tanigawa Yosuke; Perola Markus; Lemmelä Susanna; Graham Robert R; Kiiskinen Tuomo; Wainberg Michael; Turunen Joni A; Karjalainen Juha; Daly Mark J; Rivas Manuel A; FinnGen

Protein-altering variants that are protective against human disease provide in vivo validation of therapeutic targets. Here we use genotyping data from UK Biobank (n = 337,151 unrelated White British individuals) and FinnGen ...

Renal hemodynamics and fatty acid uptake: effects of obesity and weight loss

Dadson P; Iida H; Ferrannini E; Hannukainen JC; Iozzo P; Nuutila P; Rebelos E; Oikonen V

Human studies of renal hemodynamics and metabolism in obesity are insufficient. We hypothesized that renal perfusion and renal free fatty acid (FFA) uptake are higher in subjects with morbid obesity compared with lean ...

Genetic architecture of human plasma lipidome and its link to cardiovascular disease

Palta P; Whelan C; Laukkanen J; Hannula-Jouppi K; Kaarniranta K; Runz H; Challis B; Ripatti S; Hu XL; Call K; Hiltunen M; Simons K; Peterson A; Pitkanen K; Pikkarainen S; Zhou W; Soderlund S; Savinainen K; Soini S; Isomaki P; Carpen O; Smaoui N; Kujala U; Bowers N; Voutilainen M; Lehtonen A; Eaton S; Kaprio J; Ollila T; Kangasniemi E; Tuomi T; Landenpera S; Mannermaa A; Makela T; Teng E; Muslin A; Chang D; Huhtakangas J; Service SK; Mantere T; Auro K; Klinger K; Laukkanen M; Fox C; Kristiansson K; Waring J; Kononen J; Kiviniemi M; Kilpelainen E; Chen X; Laakkonen E; Rivas M; Elenius K; Harju T; Soininen H; Metsarinne K; Plenge R; Palotie A; Pelkonen M; Kurki M; Donner K; Yang R; Podgornaia A; Tuovila O; Schutzman J; Awaisa G; Sistonen T; Loukola A; Kuopio T; Perola M; Davis JW; Karlsson A; Xu FL; Joensuu H; Palin K; Laakso M; Biswas S; Parr K; Close D; Eicher J; Turunen J; McDonough S; Siirtola H; Kulkarni D; Surma MA; Hiekkalinna T; Pirinen M; Gordillo JE; Klose C; Paloneva J; Koulu L; Chen CY; Karihtala P; Popovic R; Kiiskinen TTJ; Waterworth D; Laivuori H; Mattsson H; Koskinen M; Kalpala K; Diogo D; Petrovski S; Wang XL; Kalaoja M; Usiskin K; Marshal C; Oh D; Hendolin M; Strauss E; Georgantas B; McCarthy M; Wu Y; Lahteenmaki S; Kaarteenaho R; Schleutker J; Uusitalo-Jarvinen H; Riley-Gillis B; Pulkki K; Liu J; Salomaa V; Ganna A; Kaipiainen-Seppanen O; Freimer NB; Taskinen MR; Chhibber A; Tabuenca JG; Lemmela S; Wong R; Kajanne R; McCarthy L; Hoffman J; Hinttala R; Gerl MJ; Shcherban A; Aaltonen L; Chu A; Jauhiainen M; Daly MJ; Virolainen P; Mannikko L; Ritari J; Koskela JT; Bhangale T; Pakkanen R; Uusitalo H; Kalviainen R; Hyvarinen K; John S; Kosma VM; Sipila T; Pylkas K; Maranville J; Blomster T; Ziemann A; Wahlfors T; Auge F; Mehta V; Pitkaranta A; Bing N; Harju J; Lehtonen H; Michon J; Meretoja T; Chen H; Niiranen T; Betts J; Kaunisto M; Llorens V; Ehm M; Laitinen T; Julkunen V; Tabassum R; Peltola J; Nunez-Fontarnau J; Lertratanakul A; Karjalainen M; Seitsonen S; Palomaki A; Auranen A; Holzinger E; Lyhs U; Heikkinen S; Gormley P; Tienari P; Peltonen S; Pihlajamaki J; Auvinen P; Kauppi P; Hunkapiller J; Gossel M; Matikainen N; Wang C; Luodonpaa M; Rinne J; Partanen J; Hedman A; Hassan S; Jimenez MG; Eklund K; Huilaja L; Kerchner G; Aaltonen V; Pirila L; Dada A; Kahonen M; Heap G; Harvima I; Crohns M; Hochfeld M; Lehisto A; Tasanen K; Loboda A; Junttila J; Ripatti P; Jalanko A; Pulford D; Hautala N; Kallio L; Juonala M; Parkkinen J; Ramo JT; Esmaeeli S; Matakidou A; Sipila TP; Linden K; Salmi T; Parolo PD; Greenberg S; Brein G; Miller M; Laiho P; Kettunen J; Malarstig A; Karjalainen J; Jacob H; Vainio S; Bronson P; Chatelain C; Laaksonen R; Rahimov F; Arvas M; Lu T; Quarless D; Xu E; Stitziel NO; Jussila A; Remes A; Sinisalo J; Havulinna AS; Kaiharju E; Kilpi T; Jarvensivu E; Mars N; Kauppila S; Farkkila M; Kankaanranta H; Ghosh S

Understanding genetic architecture of plasma lipidome could provide better insights into lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome-wide association analyses of 141 lipid species ...

Genomic prediction of alcohol-related morbidity and mortality

Madden PAF; Mars NJ; Makela P; Koskela J; Salomaa V; Kiiskinen T; Rose RJ; Palotie A; Kaprio J; Ramo JT; Havulinna AS; Ripatti P; Ripatti S; Palviainen T; Ruotsalainen S

While polygenic risk scores (PRS) have been shown to predict many diseases and risk factors, the potential of genomic prediction in harm caused by alcohol use has not yet been extensively studied. Here, we built a novel ...

Brain free fatty acid uptake is elevated in morbid obesity, and is irreversible 6 months after bariatric surgery: A positron emission tomography study

Jussi Hirvonen; Eleni Rebelos; Pirjo Nuutila; Laura Pekkarinen; Lauri Nummenmaa; Jarna C. Hannukainen; Paulina Salminen; Patricia Iozzo; Mikko Nyman; Marco Bucci; Ele Ferrannini

<h3>Aim</h3><p>To investigate whether there are differences in brain fatty acid uptake (BFAU) between morbidly obese and lean subjects, and the effect of weight loss following bariatric surgery.</p><h3>Materials and ...