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Insights into disseminated MS brain pathology with multimodal diffusion tensor and PET imaging
<div>Objective To evaluate in vivo the co-occurrence of microglial activation and microstructural white matter (WM) damage in the MS brain and to examine their association with clinical disability.</div><div>Methods 18-kDa ...
A Systematic Review of the Usefulness of Glial Fibrillary Acidic Protein for Predicting Acute Intracranial Lesions following Head Trauma
Background: The extensive use of computed tomography (CT) after acute head injury is costly and carries potential iatrogenic risk. This systematic review examined the usefulness of blood-based glial fibrillary acidic protein ...
Long-Term Outcomes of Surgical Aortic Valve Replacement in Patients with Rheumatoid Arthritis
Background: Patients with rheumatoid arthritis (RA) have increased risk of developing cardiovascular disease and events. Little is, however, known about the influence of RA to the outcomes after surgical aortic valve ...
Consensus-based statements for the management of mitochondrial stroke-like episodes
<p>Background: Focal-onset seizures and encephalopathy are prominent features of a stroke-like episode, which is a severe neurological manifestation associated with subtypes of mitochondrial disease. Despite more than 30 ...
Differences between Men and Women in Treatment and Outcome after Traumatic Brain Injury
<p>Traumatic brain injury (TBI) is a significant cause of disability, but little is known about sex and gender differences after TBI. We aimed to analyze the association between sex/gender, and the broad range of care ...
Global Characterisation of Coagulopathy in Isolated Traumatic Brain Injury (iTBI): A CENTER-TBI Analysis
Background <div>Trauma-induced coagulopathy in patients with traumatic brain injury (TBI) is associated with high rates of complications, unfavourable outcomes and mortality. The mechanism of the development of TBI-associated ...
Efficacy and safety outcomes in vitamin D supplement users in the fingolimod phase 3 trials
<h4>BACKGROUND:</h4><p>Low serum levels of 25-hydroxyvitamin D have been associated with worse outcomes in multiple sclerosis (MS) patients treated with interferon-beta. Association of vitamin D nutrition on the outcomes ...
Association between microglial activation and serum kynurenine pathway metabolites in multiple sclerosis patients
<p>Background<br></p><p>Microglial activation associates with MS progression but it is unclear what drives their persistent pro-inflammatory state. Metabolites of the kynurenine pathway (KP), the main metabolism route of ...
Burden of non-motor symptoms in unclear parkinsonism and tremor: A study with [I-123]FP-CIT SPECT
Background: Non-motor symptoms (NMSs) are clearly more prevalent in Parkinson's disease (PD) patients compared to healthy individuals. However, NMSs are also common in the elderly and other neurological conditions, and ...
Terveydentila- ja toimintakykymittareiden hyödyntäminen lääkehoidon toteutuksessa iäkkäiden kotihoidossa
<p>Johdanto: Iäkkäiden kotihoidon asiakkaiden terveydentilaa ja toimintakykyä arvioidaan säännöllisesti<br>erilaisin mittarein. Tässä tutkimuksessa tutkittiin, mitä terveydentila- ja toimintakykymittareita on käytössä ja ...