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Therapeutic Potential of Targeting the SUMO Pathway in Cancer
<p> The small ubiquitin-like modifier (SUMO) pathway regulates the hallmark properties of cancer cells. Moreover, alterations in activity and in levels of SUMO machinery components have been observed in human cancer. Due ...
Identification of Predictive ERBB Mutations by Leveraging Publicly Available Cell Line Databases
While targeted therapies can be effective for a subgroup of patients, identification of individuals who benefit from the treatments is challenging. At the same time, the predictive significance of the vast majority of the ...
Structural Basis for the Functional Changes by EGFR Exon 20 Insertion Mutations
<div><b>Simple Summary</b></div><div>Non-small cell lung cancer (NSCLC) is the most common type of lung cancer that claims the lives of many worldwide. Activating mutations occurring on the epidermal growth factor receptor ...
An Unbiased Functional Genetics Screen Identifies Rare Activating ERBB4 Mutations
<p>Despite the relatively high frequency of somatic <i>ERBB4</i> mutations in various cancer types, only a few activating <i>ERBB4</i> mutations have been characterized, primarily due to lack of mutational hotspots in ...
An extracellular receptor tyrosine kinase motif orchestrating intracellular STAT activation
The ErbB4 receptor isoforms JM-a and JM-b differ within their extracellular juxtamembrane (eJM) domains. Here, ErbB4 isoforms are used as a model to address the effect of structural variation in the eJM domain of receptor ...
Geenidiagnostiikkaan perustuva syövän hoito - ovatko odotukset toteutuneet?
Geenidiagnostiikka on viime vuosina herättänyt odotuksia syövän tehokkaammasta hoidosta. Syövän kohdennetut lääkehoidot ovat lisääntyneet ja kehittyneet, ja syövän hoidon valinta on nykyään mahdollista pienellä osalla ...