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Receptor tyrosine kinase profiling of ischemic heart identifies ROR1 as a potential therapeutic target

Maria Laaksonen; Ilkka Paatero; Timo Savunen; Deepankar Chakroborty; Juho Heliste; Klaus Elenius; Christoffer Stark; Anne Jokilammi

BackgroundReceptor tyrosine kinases (RTK) are potential targets for the treatment of ischemic heart disease. The human RTK family consists of 55 members, most of which have not yet been characterized for expression or ...

An easily adaptable validated risk score predicts cancer-specific survival in stage II colon cancer

Heikki Minn; Arto Rantala; Raija Ristamäki; Anu Carpelan; Annika Ålgars; Heikki Huhtinen; Tapio Salminen; Vesa Väliaho; Lasse Nieminen; Eetu Heervä; Samu Kurki; Jari Sundström; Pia Österlund; Olli Carpén

Immunological tumor status may predict response to neoadjuvant chemotherapy and outcome after radical cystectomy in bladder cancer

Bostrom PJ; Koskinen I; Ecke T; Mirtti T; Tervahartiala M; Jalkanen S; Taimen P

Bladder cancer (BC) is the ninth most common cancer worldwide. Radical cystectomy (RC) with neoadjuvant chemotherapy (NAC) is recommended for muscle-invasive BC. The challenge of the neoadjuvant approach relates to challenges ...

Trends in presentation, treatment and survival of 1777 patients with colorectal cancer over a decade: a Biobank study

Anu Carpelan; Heikki Minn; Eetu Heervä; Arto Rantala; Jari Sundström; Annika Ålgars; Olli Carpén; Raija Ristamäki; Samu Kurki; Heikki Huhtinen

<p><b>Background:</b> Most survival data in colorectal cancer (CRC) is derived from clinical trials or register-based studies. Hospital Biobanks, linked with hospital electronic records, could serve as a data-gathering ...

Prognostic Role of Survivin and Macrophage Infiltration Quantified on Protein and mRNA Level in Molecular Subtypes Determined by RT-qPCR of KRT5, KRT20, and ERBB2 in Muscle-Invasive Bladder Cancer Treated by Adjuvant Chemotherapy

Minna Tervahartiala; Peter Boström; Thorsten Schlomm; Jan Gleichenhagen; Anja Rabien; Thomas Brüning; Frank Friedersdorff; Thorsten H Ecke; Stefan Koch; Ralph M Wirtz; Adisch Kiani; Jenny Roggisch; Klaus Jung; Pekka Taimen; Georg Johnen; Ergin Kilic

<p>Objectives: Bladder cancer is a heterogeneous malignancy. Therefore, it is difficult to find single predictive markers. Moreover, most studies focus on either the immunohistochemical or molecular assessment of tumor ...

Preperitoneal Fat Grafting Inhibits the Formation of Intra-abdominal Adhesions in Mice

Pauliina Hartiala; Heidi Gerke; Erika Hoppela; Mervi Laukka; Katri Orte; Kaisa Auvinen; Pirjo Merilahti; Emilia Peuhu; Saila Kauhanen; Pia Rantakari; Kerstin Thol; Tove J. Gronroos; Jemiina Salo; Marko Salmi

<div><h4>BACKGROUND: </h4><p>Adhesion formation contributes to postoperative complications in abdominal and gynaecological surgery. Thus far, the prevention and treatment strategies have focused on mechanical barriers ...

Red blood cell transfusion induces abnormal HIF-1 alpha response to cytokine storm after adult cardiac surgery

Kiviniemi Tuomas O.; Gunn Jarmo; Jalkanen Juho; Viikinkoski Emma; Vasankari Tuija; Lehto Joonas; Jalkanen Sirpa; Valtonen Mika; Biancari Fausto; Hollmén Maija; Airaksinen Juhani

Patients undergoing cardiac surgery develop a marked postoperative systemic inflammatory response. Blood transfusion may contribute to disruption of homeostasis in these patients. We sought to evaluate the impact of blood ...