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Atopic asthma after rhinovirus-induced wheezing is associated with DNA methylation change in the SMAD3 gene promoter
<p>Children with rhinovirus-induced severe early wheezing have an increased risk of developing asthma later in life. The exact molecular mechanisms for this association are still mostly unknown. To identify potential changes ...
Receptor tyrosine kinase profiling of ischemic heart identifies ROR1 as a potential therapeutic target
BackgroundReceptor tyrosine kinases (RTK) are potential targets for the treatment of ischemic heart disease. The human RTK family consists of 55 members, most of which have not yet been characterized for expression or ...
Protein synthesis is suppressed in sporadic and familial Parkinson's disease by LRRK2
Gain of function LRRK2-G2019S is the most frequent mutation found in familial and sporadic Parkinson's disease. It is expected therefore that understanding the cellular function of LRRK2 will provide insight on the ...
An Infancy-Onset 20-Year Dietary Counselling Intervention and Gut Microbiota Composition in Adulthood
The randomized controlled Special Turku Coronary Risk Factor Intervention Project (STRIP) has completed a 20-year infancy-onset dietary counselling intervention to reduce exposure to atherosclerotic cardiovascular disease ...
A predictive model of overall survival in patients with metastatic castration-resistant prostate cancer
<p>Metastatic castration resistant prostate
cancer (mCRPC) is one of the most common cancers with a poor prognosis.
To improve prognostic models of mCRPC, the Dialogue for Reverse
Engineering Assessments and Methods ...
Peripheral blood DNA methylation differences in twin pairs discordant for Alzheimer's disease
<p>Background <br></p><p>Alzheimer's disease results from a neurodegenerative process that starts well before the diagnosis can be made. New prognostic or diagnostic markers enabling early intervention into the disease ...
Tool evaluation for the detection of variably sized indels from next generation whole genome and targeted sequencing data
<p>Insertions and deletions (indels) in human genomes are associated with a wide range of phenotypes, including various clinical disorders. High-throughput, next generation sequencing (NGS) technologies enable the detection ...
Gut Microbiota Richness and Composition and Dietary Intake of Overweight Pregnant Women Are Related to Serum Zonulin Concentration, a Marker for Intestinal Permeability
Background: Increased intestinal permeability may precede adverse metabolic conditions. The extent to which the composition of the gut microbiota and diet contribute to intestinal permeability during pregnancy is ...