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Repeated centralized multidisciplinary team assessment of resectability, clinical behavior, and outcomes in 1086 Finnish metastatic colorectal cancer patients (RAXO): A nationwide prospective intervention study
<p><strong>Background</strong>: Resection of colorectal cancer (CRC) metastases provides good survival but is probably underused in real-world practice.</p><p><strong>Methods</strong>: A prospective Finnish nationwide study ...
Maksasolusyövän onkologinen lääkehoito
<p>Maksasolusyöpä yleistyy Suomessa. Sorafenibi, suun kautta otettava tyrosiinikinaasin estäjä, on pitkään ollut leikkaukseen soveltumattoman tai edenneen maksasolusyövän lääkehoidon kulmakivi. Hoito on luonteeltaan ...
Improved risk prediction of chemotherapy-induced neutropenia-model development and validation with real-world data
<p><strong>Background</strong> The existing risk prediction models for chemotherapy-induced febrile neutropenia (FN) do not necessarily apply to real-life patients in different healthcare systems and the external validation ...
Signaling pathways in human osteoclasts differentiation: ERK1/2 as a key player
<p>Little is known about the signaling pathways involved in the differentiation of human osteoclasts. The present study evaluated the roles of the Ras/PI3K/Akt/mTOR, Ras/Raf/MEK1/2/ERK1/2, calcium-PKC, and p38 signaling ...