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Atopic asthma after rhinovirus-induced wheezing is associated with DNA methylation change in the SMAD3 gene promoter
<p>Children with rhinovirus-induced severe early wheezing have an increased risk of developing asthma later in life. The exact molecular mechanisms for this association are still mostly unknown. To identify potential changes ...
Early suppression of immune response pathways characterizes children with prediabetes in genome-wide gene expression profiling
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Type 1 diabetes (T1D) is caused by autoimmune destruction of insulin-producing pancreatic p cells in the islets of Langerhans. Although defects in various T cell subsets have been linked to the disease pathogenesis, ...
An Infancy-Onset 20-Year Dietary Counselling Intervention and Gut Microbiota Composition in Adulthood
The randomized controlled Special Turku Coronary Risk Factor Intervention Project (STRIP) has completed a 20-year infancy-onset dietary counselling intervention to reduce exposure to atherosclerotic cardiovascular disease ...
Enterovirus-associated changes in blood transcriptomic profiles of children with genetic susceptibility to type 1 diabetes
<div><h4>AIMS/HYPOTHESIS: </h4><p>Enterovirus
infections have been associated with the development of type 1 diabetes
in multiple studies, but little is known about enterovirus-induced
responses in children at risk ...