Hae
Aineistot 1-10 / 19
Breast cancer in neurofibromatosis type 1: overrepresentation of unfavourable prognostic factors
<div><h3>Abstract</h3><div><h4>BACKGROUND: </h4><p>An increased breast cancer incidence and poor survival have been reported for women with neurofibromatosis 1 (NF1). To explain the poor survival, we aimed to link the ...
The role of polygenic risk and susceptibility genes in breast cancer over the course of life
Polygenic risk scores (PRS) for breast cancer have potential to improve risk prediction, but there is limited information on their utility in various clinical situations. Here we show that among 122,978 women in the FinnGen ...
Rare protein-altering variants in ANGPTL7 lower intraocular pressure and protect against glaucoma
Protein-altering variants that are protective against human disease provide in vivo validation of therapeutic targets. Here we use genotyping data from UK Biobank (n = 337,151 unrelated White British individuals) and FinnGen ...
Genetic architecture of human plasma lipidome and its link to cardiovascular disease
Understanding genetic architecture of plasma lipidome could provide better insights into lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome-wide association analyses of 141 lipid species ...
Long Noncoding RNA PICSAR Promotes Growth of Cutaneous Squamous Cell Carcinoma by Regulating ERK1/2 Activity
Keratinocyte-derived cutaneous squamous cell carcinoma (cSCC) is the
most common metastatic skin cancer, and its incidence is increasing
globally. Long noncoding RNAs (lncRNA) are involved in various
biological ...
Super Enhancer-Regulated LINC00094 (SERLOC) Upregulates the Expression of MMP-1 and MMP-13 and Promotes Invasion of Cutaneous Squamous Cell Carcinoma
<p>Simple Summary <br></p><p>Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer, and its incidence is increasing worldwide. The prognosis of the metastatic disease is poor, and there are no ...
Tumour-cell-derived complement components C1r and C1s promote growth of cutaneous squamous cell carcinoma
<p><strong>Background</strong> The incidence of epidermal keratinocyte-derived cutaneous squamous cell carcinoma (cSCC) is increasing worldwide. </p><p><strong>Objectives</strong> To study the role of the complement classical ...
p53-Regulated Long Noncoding RNA PRECSIT Promotes Progression of Cutaneous Squamous Cell Carcinoma via STAT3 Signaling
<p>Long noncoding RNAs (lncRNAs) have emerged as putative biomarkers and therapeutic targets in cancer. The role of lncRNA LINC00346 in cutaneous squamous carcinoma (cSCC) was examined. The expression of LINC00346 was ...