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Dietary Intervention in Infancy and Cognitive Function in Young Adulthood: The Special Turku Coronary Risk Factor Intervention Project

Jula Antti; Raitakari Olli T.; Niinikoski Harri; Viikari Jorma S.A.; Rönnemaa Tapani; Pahkala Katja; Lagström Hanna; Salo Pia; Salo Henri; Rovio Suvi P.

Objective: Consumption of saturated fatty acids (SAFAs), polyunsaturated fatty acids (PUFAs), cholesterol, and fiber have been linked with cognitive function in adults. We evaluated these associations ...

Weight gain in infancy and markers of cardiometabolic health in young adulthood

Pahkala Katja; Viikari Jorma; Salo Pia; Jula Antti; Rönnemaa Tapani; Nummela Saga R; Raitakari Olli T; Rovio Suvi P; Niinikoski Harri

Aim We studied whether repeatedly measured weight gain from birth up to age 2 years associated with cardiometabolic health in young adulthood. Methods Using the data collected in the longitudinal Special Turku Coronary ...

Circulating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis

Schulze MB; Travis R; Salmi M; Zuber V; Palaniswamy S; Jalkanen S; PRACTICAL consortium; Karhunen V; Brennan P; Lehtimaki T; Raitakari O; Salomaa V; Hung RJ; Katsoulis M; Martin P; Keinanen-Kiukaanniemi S; Mannikko M; Murphy N; Ahola-Olli A; Huang J; Haycock PC; Amos CI; Jarvelin MR; Gunter MJ; Martin RM; Lewis SJ; Dossus L; Key T; Auvinen J; Platz EA; Dehghan A; Nost TH; Herzig KH; Freisling H; Yarmolinsky J; Gill D; Tsilidis KK; Bouras E; Johansson M

Background: Epidemiological and experimental evidence has linked chronic inflammation to cancer aetiology. It is unclear whether associations for specific inflammatory biomarkers are causal or due to ...

Sydän- ja verisuonitautien ehkäisy kannattaa aloittaa jo vauvasta - STRIP-tutkimus näyttää miksi ja miten

Viikari Jorma; Niinikoski Harri; Laitinen Tomi T; Raitakari Olli; Jula Antti; Salo Pia; Rönnemaa Tapani; Jokinen Eero; Pahkala Katja; Lagström Hanna; Rovio Suvi

Satunnaistetussa STRIP-tutkimuksessa 562 tervettä lasta sai tyydyttyneen rasvan saannin vähentämiseen tähtäävää ravitsemusneuvontaa kahdeksan kuukauden iästä alkaen 20 vuoden ikään asti, ja 545 saman ikäistä lasta seurattiin ...

Permutation-based significance analysis reduces the type 1 error rate in bisulfite sequencing data analysis of human umbilical cord blood samples

Rasool Omid; Lietzén Niina; Grönroos Toni; Kallionpää Henna; Lund Riikka; Vähä-Mäkilä Mari; Halla-Aho Viivi; Oresic Matej; Lahesmaa Riitta; Mykkänen Juha; Nurmio Mirja; Laajala Essi; Kalim Ubaid Ullah; Toppari Jorma; Knip Mikael; Lähdesmäki Harri

DNA methylation patterns are largely established in-utero and might mediate the impacts of in-utero conditions on later health outcomes. Associations between perinatal DNA methylation marks and pregnancy-related variables, ...

Umbilical cord blood DNA methylation in children who later develop type 1 diabetes

Grönroos Toni; Toppari Jorma; Konki Mikko; Halla-aho Viivi; Vähä-Mäkilä Mari; Kalim Ubaid U; Nurmio Mirja; Lähdesmäki Harri; Laajala Essi; Lahesmaa Riitta; Orešič Matej; Hyöty Heikki; Kallionpää Henna; Mykkänen Juha; Rasool Omid; Knip Mikael; Kattelus Roosa; Lietzen Niina; Lund Riikka J; Ilonen Jorma; Veijola Riitta; Ghimire Bishwa R; Elo Laura L; Laiho Asta

Aims/hypothesis: Distinct DNA methylation patterns have recently been observed to precede type 1 diabetes in whole blood collected from young children. Our aim was to determine whether perinatal DNA ...

Type 1 Diabetes in Children With Genetic Risk May Be Predicted Very Early With a Blood miRNA

Lahesmaa Riitta; Nurmio Mirja; Toppari Jorma; Mykkänen Juha; Knip Mikael; Elo Laura L; Kalim Ubaid Ullah; Laiho Asta; Rasool Omid; Kallionpää Henna; Ilonen Jorma; Härkönen Taina; Suomi Tomi; Hyöty Heikki; Vähä-Mäkilä Mari; Veijola Riitta

An Infancy-Onset 20-Year Dietary Counselling Intervention and Gut Microbiota Composition in Adulthood

Jula Antti; Rönnemaa Tapani; Keskitalo Anniina; Kartiosuo Noora; Rovio Suvi P; Pahkala Katja; Lahti Leo; Huovinen Pentti; Pietilä Sami; Niinikoski Harri; Aatsinki Anna; Raitakari Olli; Elo Laura L; Lagström Hanna; Viikari Jorma; Munukka Eveliina; Saleem Wisam

The randomized controlled Special Turku Coronary Risk Factor Intervention Project (STRIP) has completed a 20-year infancy-onset dietary counselling intervention to reduce exposure to atherosclerotic cardiovascular disease ...