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Islet Autoimmunity and HLA Markers of Presymptomatic and Clinical Type 1 Diabetes: Joint Analyses of Prospective Cohort Studies in Finland, Germany, Sweden, and the US

Frohnert Brigitte I.; Veijola Riitta; Killian Michael B.; Ghalwash Mohamed; Toppari Jorma; Winkler Christiane; Jonsson Josefine; Ng Kenney; Ziegler Anette-Gabriele; Lundgren Markus; Hagopian William; Koski Eileen; Dunne Jessica L.; Knip Mikael; Anand Vibha; Rewers Marian; for the T1DI Study Group; Ilonen Jorma; Liu Bin; Li Ying

<div><p>OBJECTIVE</p><p>To combine prospective cohort studies, by including HLA harmonization, and estimate risk of islet autoimmunity and progression to clinical diabetes.<br></p><p>RESEARCH DESIGN AND METHODS<br></p><p>For ...

Progression of type 1 diabetes from latency to symptomatic disease is predicted by distinct autoimmune trajectories

Hagopian William; Koski Eileen; Toppari Jorma; Dunne Jessica L; Lundgren Markus; Anand Vibha; Frohnert Brigitte I; the T1DI Study Group; Veijola Riitta; Achenbach Peter; Hu Jianying; Lernmark Åke; Ng Kenney; Kwon Bum Chul

Development of islet autoimmunity precedes the onset of type 1 diabetes in children, however, the presence of autoantibodies does not necessarily lead to manifest disease and the onset of clinical symptoms is hard to ...