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Application of the PET ligand [C-11]ORM-13070 to examine receptor occupancy by the alpha(2C)-adrenoceptor antagonist ORM-12741: translational validation of target engagement in rat and human brain
<b>Background</b><div>Availability of the α<sub>2C</sub>-adrenoceptor (α2C-AR) positron emission tomography (PET) tracer, [<sup>11</sup>C]ORM-13070, and the α2C-AR antagonist ORM-12741 allows probing of the roles of this ...