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Arpp19 Promotes Myc and Cip2a Expression and Associates with Patient Relapse in Acute Myeloid Leukemia
Disease relapse from standard chemotherapy in acute myeloid leukemia (AML) is poorly understood. The importance of protein phosphatase 2A (PP2A) as an AML tumor suppressor is emerging. Therefore, here, we examined the ...
The Influence of AA29504 on GABA A Receptor Ligand Binding Properties and Its Implications on Subtype Selectivity
The unique pharmacological properties of δ-containing γ-aminobutyric acid type A receptors (δ-GABA<sub>A</sub>Rs) make them an attractive target for selective and persistent modulation of neuronal excitability. However, ...
Detecting disease associated biomarkers by luminescence modulating phages
Assessment of risk for a given disease and the diagnosis of diseases is often based on assays detecting biomarkers. Antibody-based biomarker-assays for diseases such as prostate cancer are often ambiguous and biomarker ...
Gene fusions and oncogenic mutations in MLH1 deficient and BRAFV600E wild-type colorectal cancers
Gene fusions can act as oncogenic drivers and offer targets for cancer therapy. Since fusions are rare in colorectal cancer (CRC), their universal screening seems impractical. Our aim was to investigate gene fusions in 62 ...
Signaling pathways in human osteoclasts differentiation: ERK1/2 as a key player
<p>Little is known about the signaling pathways involved in the differentiation of human osteoclasts. The present study evaluated the roles of the Ras/PI3K/Akt/mTOR, Ras/Raf/MEK1/2/ERK1/2, calcium-PKC, and p38 signaling ...
Enterovirus-associated changes in blood transcriptomic profiles of children with genetic susceptibility to type 1 diabetes
<div><h4>AIMS/HYPOTHESIS: </h4><p>Enterovirus
infections have been associated with the development of type 1 diabetes
in multiple studies, but little is known about enterovirus-induced
responses in children at risk ...
New prostate cancer grade grouping system predicts survival after radical prostatectomy
<p>Histological Gleason grading of <a title="Learn more about Prostate Cancer" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/prostate-cancer"><u>prostate cancer</u></a> has been through modifications ...
Placental DNA methylation marks are associated with maternal depressive symptoms during early pregnancy
<p>Maternal depressive symptoms during pregnancy are a significant risk factor for adverse developmental and health outcomes of the offspring. The molecular mechanisms mediating the long-term effects of this exposure are ...
Whole blood based point-of-care assay for the detection of anti-pertussis toxin IgG antibodies
Current serological diagnosis of pertussis is usually done by ELISA to determine serum specific anti-pertussis toxin (PT) IgG antibodies. However, the ELISAs are often central-laboratory based, require trained staff, and ...