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Computational Analysis of HLA-presentation of Non-synonymous Recipient Mismatches Indicates Effect on the Risk of Chronic Graft-vs.-Host Disease After Allogeneic HSCT
Genetic mismatches in protein coding genes between allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipient and donor can elicit an alloimmunity response via peptides presented by the recipient HLA receptors ...
Kielletyt aineet ja menetelmät urheilussa ja erivapaus urheilijan lääkityksessä
<p>Dopingvalvonnan alaiset kilpaurheilijat sairastavat ja voivat tarvita hoitoa lääkkeillä tai menetelmillä, jot‑
ka ovat kiellettyjen aineiden ja menetelmien luettelossa. Urheilussa kielletyt lääkeaineet voi tarkistaa
Suomessa ...
Brown fat triglyceride content is associated with cardiovascular risk markers in adults from a tropical region
Brown adipose tissue (BAT) is regarded as an interesting potential target for the treatment of obesity, diabetes, and cardiovascular diseases, and the detailed characterization of its structural and functional phenotype ...
Efficacy and safety outcomes in vitamin D supplement users in the fingolimod phase 3 trials
<h4>BACKGROUND:</h4><p>Low serum levels of 25-hydroxyvitamin D have been associated with worse outcomes in multiple sclerosis (MS) patients treated with interferon-beta. Association of vitamin D nutrition on the outcomes ...
Feasibility of FreeSurfer Processing for T1-Weighted Brain Images of 5-Year-Olds: Semiautomated Protocol of FinnBrain Neuroimaging Lab
<p>Pediatric neuroimaging is a quickly developing field that still faces important methodological challenges. Pediatric images usually have more motion artifact than adult images. The artifact can cause visible errors in ...
The importance of and satisfaction with sex life among breast cancer survivors in comparison with healthy female controls and women with mental depression or arterial hypertension: results from the Finnish nationwide HeSSup cohort study
<p>Introduction</p><p>Breast cancer (BC) and its treatment is associated with several physical and psychosocial changes that may influence sexuality for years after treatment. Women with BC show significantly greater rates ...
Tears of Biceps Femoris, Semimembranosus, And Semitendinosus are Not Equal—A New Individual Muscle-Tendon Concept in Athletes
<p><strong>Objectives: </strong>Hamstring injuries are common and can now be accurately diagnosed. In addition, novel surgical indications have been introduced. However, evidence-based guidelines on the hamstring injuries ...
Association between microglial activation and serum kynurenine pathway metabolites in multiple sclerosis patients
<p>Background<br></p><p>Microglial activation associates with MS progression but it is unclear what drives their persistent pro-inflammatory state. Metabolites of the kynurenine pathway (KP), the main metabolism route of ...
Burden of non-motor symptoms in unclear parkinsonism and tremor: A study with [I-123]FP-CIT SPECT
Background: Non-motor symptoms (NMSs) are clearly more prevalent in Parkinson's disease (PD) patients compared to healthy individuals. However, NMSs are also common in the elderly and other neurological conditions, and ...
Contraindications to immunotherapy: a global approach
Background Recommendations on contraindications to allergen immunotherapy (AIT) have been independently developed by National and International Societies/Academies. AIT contraindications are mainly based on case reports, ...