Hae
Aineistot 11-20 / 88
Rates and age trends in lumbar fusions in 2002 – 2017 – a descriptive analysis of 3,000 patients
<p>Objective</p><p>The objective of this study was to describe the change in rates and age averages among patients undergoing lumbar fusion during the last 20 years in a university hospital district located in Finland.</p><p>Methods</p><p>The data on 3,066 fusion surgeries were obtained from an electronic register between 2002 – 2017. The t-test, chi square, and regression analyses were used.</p><p>Results</p><p>In 2002 – 2017, 3,066 patients underwent lumbar fusion. The annual fusion rates grew in 16 years by 500%. The regression coefficient for annual rates of lumbar fusion procedures was 17.4 (95% CI 14.8 to 20.0, p-value <0.0001) procedure/year. In general, the patients were becoming older over time with regression coefficient 0.67 (95% CI 0.55 to 0.78, p-value <0.0001, R20.04) year/year.</p><p>Conclusions</p><p>In the studied cohort, the annual rates of lumbar fusions grew explosively during the last 16 years by 500% and the patients were 10 years older in 2017 than back in 2002. It seems, that if the trend observed here will continue then fusion patients may on average be even 20 years older in 2030 than they were in 2002. Surgeons and policy makers should take this probability under consideration when planning future techniques, rehabilitation, and allocation of funding.</p>...
Renal hemodynamics and fatty acid uptake: effects of obesity and weight loss
Human studies of renal hemodynamics and metabolism in obesity are insufficient. We hypothesized that renal perfusion and renal free fatty acid (FFA) uptake are higher in subjects with morbid obesity compared with lean ...
Genetic architecture of human plasma lipidome and its link to cardiovascular disease
Understanding genetic architecture of plasma lipidome could provide better insights into lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome-wide association analyses of 141 lipid species ...
Genomic prediction of alcohol-related morbidity and mortality
While polygenic risk scores (PRS) have been shown to predict many diseases and risk factors, the potential of genomic prediction in harm caused by alcohol use has not yet been extensively studied. Here, we built a novel ...
FDG-PET/CT(A) imaging in large vessel vasculitis and polymyalgia rheumatica: joint procedural recommendation of the EANM, SNMMI, and the PET Interest Group (PIG), and endorsed by the ASNC
Large vessel vasculitis (LVV) is defined as a disease mainly affecting the large arteries, with two major variants. Takayasu arteritis (TA) and giant cell arteritis (GCA). GCA often coexists with polymyalgia rheumatica ...
Affective Adaptation to Repeated SIT and MICT Protocols in Insulin-Resistant Subjects
Introduction The aim of this study was to investigate affective responses to repeated sessions of sprint interval training (SIT) in comparison with moderate-intensity continuous training (MICT) in insulin-resistant ...
Specific loss of adipocyte CD248 improves metabolic health via reduced white adipose tissue hypoxia, fibrosis and inflammation
<p>Background: A positive energy balance promotes white adipose tissue (WAT) expansion which is characterized by activation of a repertoire of events including hypoxia, inflammation and extracellular matrix remodelling. ...
High angular resolution diffusion-weighted imaging in mild traumatic brain injury
We sought to investigate white matter abnormalities in mild traumatic brain injury (mTBI) using diffusion-weighted magnetic resonance imaging (DW-MRI). We applied a global approach based on tract-based spatial statistics ...
Health-Related Quality of Life in Metastatic Colorectal Cancer Patients Treated with Curative Resection and/or Local Ablative Therapy or Systemic Therapy in the Finnish RAXO-Study
<p>Simple Summary <br></p><p>Metastatic colorectal cancer is the second most common cause of cancer death. Long-term survival and cure can be achieved after intensive treatments, including metastasectomy, i.e., the removal ...