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Pertussis in infants in Nordic countries
<b>Aim:</b> A life-course immunisation approach is required to prevent and control pertussis. We aimed at reviewing pertussis incidence among infants in Denmark, Finland, Norway and Sweden, and at putting these data in the ...
Differences in epitope-specific antibodies to pertussis toxin after infection and acellular vaccinations
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<p>
<strong>
Objectives:
</strong>
Pertussis toxin (PT) is a component of all acellular pertussis
vaccines. PT must be ...
Association of Early β-Amyloid Accumulation and Neuroinflammation Measured With [11C]PBR28 in Elderly Individuals Without Dementia
<p>OBJECTIVE: To examine whether early β-amyloid (Aβ) accumulation and metabolic risk factors are associated with neuroinflammation in elderly individuals without dementia. METHODS: We examined 54 volunteers (mean age 70.0 ...
Sikiökautinen ympäristö säätelee elintapasairauksien riskiä
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<p>•Aikuisiän sairauksien riskin ohjelmoitumisella tarkoitetaan
ympäristön vaikutusta kehittyvään yksilöön sikiöajan ja
varhaislapsuuden herkkyyskausien aikana.
</p>
<p>•Ohjelmoitumisessa sikiö sopeutuu ...
Inhaled Sargramostim Induces Resolution of Pulmonary Alveolar Proteinosis in Lysinuric Protein Intolerance
<p>Pulmonary alveolar proteinosis (PAP) is a potentially fatal complication of lysinuric protein intolerance (LPI), an inherited disorder of cationic amino acid transport. The patients often present with mild respiratory ...
Bronchiolitis needs a revisit: Distinguishing between virus entities and their treatments
<p>Current data indicate that the “bronchiolitis” diagnosis comprises more than one condition. Clinically, pathophysiologically, and even genetically three main clusters of patients can be identified among children suffering ...
An Infancy-Onset 20-Year Dietary Counselling Intervention and Gut Microbiota Composition in Adulthood
The randomized controlled Special Turku Coronary Risk Factor Intervention Project (STRIP) has completed a 20-year infancy-onset dietary counselling intervention to reduce exposure to atherosclerotic cardiovascular disease ...
A practical laboratory index to predict institutionalization and mortality - an 18-year population-based follow-up study
<p><strong></strong><strong>Background </strong><br></p><p>Previously, several indexes based on a large number of clinical and laboratory tests to predict mortality and frailty have been produced. However, there is still a need for an easily applicable screening tool for every-day clinical practice.</p><p><strong>Methods</strong> <br></p><p>A prospective study with 10- and 18-year follow-ups. Fourteen common laboratory tests were combined to an index. Cox regression model was used to analyse the association of the laboratory index with institutionalization and mortality.<br></p><p><strong>Results</strong> <br></p><p>The mean age of the participants (n =1153) was 73.6 (SD 6.8, range 64.0-100.0) years. Altogether, 151 (14.8%) and 305 (29.9%) subjects were institutionalized and 422 (36.6%) and 806 (69.9%) subjects deceased during the 10- and 18-year follow-ups, respectively. Higher LI (laboratory index) scores predicted increased mortality. Mortality rates increased as LI scores increased both in unadjusted and in age- and gender-adjusted models during both follow-ups. The LI did not significantly predict institutionalization either during the 10- or 18-year follow-ups.<br></p><p><strong>Conclusions</strong> <br></p><p>A practical index based on routine laboratory tests can be used to predict mortality among older people. An LI could be automatically counted from routine laboratory results and thus an easily applicable screening instrument in clinical settings.</p><strong></strong>...
Food allergy in a child with de novo KAT6A mutation
Crying combined with miscellaneous gastrointestinal symptoms are typical symptoms of infant with food allergy, but are also common among children with abnormal neurological development. Mutations in KAT6A gene is known to ...
Circulating CXCR5−PD-1hi peripheral T helper cells are associated with progression to type 1 diabetes
<p>Aims/hypothesis Type 1 diabetes is preceded by a period of asymptomatic autoimmunity characterised by positivity for islet autoantibodies. Therefore, T helper cell responses that induce B cell activation are likely to ...