Hae
Aineistot 11-20 / 28
Decorin Expression in Human Vulva Carcinoma: Oncosuppressive Effect of Decorin cDNA Transduction on Carcinoma Cells
<p>The extracellular matrix proteoglycan decorin is well-known for its oncosuppressive activity. Here, decorin expression was examined in human vulva carcinoma tissue samples and in primary and commercial cell lines ...
Imaging of Tumor Hypoxia With F-18-EF5 PET/MRI in Cervical Cancer
<p>Purpose of the Report<br>The aim of this study was to evaluate the distribution of hypoxia using 18F-EF5 as a hypoxia tracer in cervical cancer patients with PET/MRI. We investigated the association between this 18F-EF5-PET ...
Infants born to women with substance use: Exploring early neurobehavior with the Dubowitz neurological examination
<div><h3>Background</h3><p>There is a special concern regarding substance using pregnant women due to the possible adverse effects on the infant. While the immediate effects of prenatal substance exposure are well known, the long-term data on the infants' <a title="Learn more about Nerve Cell Differentiation" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/nerve-cell-differentiation"><u>neurodevelopment</u></a> is inconclusive.</p></div><div><h3>Aims</h3><p>The purpose of this study was to assess early neurobehavior of infants of mothers with <a title="Learn more about Substance Use" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/substance-use"><u>substance use</u></a> using the Dubowitz examination and to follow their neuromotor development until one year of age.</p></div><div><h3>Study design and subjects</h3><p>Ninety-five pregnant women with a recent history of substance use were recruited and followed up at the maternity outpatient clinic. Follow-up data was collected from hospital records and maternal interviews. The Dubowitz neurological examination was performed to the 54 clinically healthy term infants. The results were converted into optimality scores and compared to normative values from clinically healthy term infants derived from a separate normative population. The infant's neuromotor development was followed up to one year of age.</p></div><div><h3>Results</h3><p>Only 7% of the infants born to women with recent or current substance use reached optimal scores (<30.5) in the Dubowitz neurological examination compared to 95% reported in normative population. Sixty-three percent of the newborns needed follow-up based on physiotherapeutic assessment of neurobehavior. By 12 months of age, the neuromotor status of 88% (n = 30) of these infants was found normal.</p></div><div><h3>Conclusions</h3><p>A high percentage of infants of mothers who were referred prenatally to hospital due to substance use showed suboptimal neurological findings during their first days of life.<br /></p></div>...
Outcomes of HPV type-specific serostatus do not associate with oral or genital HPV-carriage in non-vaccinated women followed for three years
<p>Background</p><p>The role of human papillomavirus (HPV) antibodies acquired through natural infection and their role in protection for subsequent cervical or oral HPV-carriage remains unclear.</p><p>Methods</p><p>A total ...
Parental divorce in childhood does not independently predict maternal depressive symptoms during pregnancy
<p>Background: This study sought to investigate if parental divorce in childhood increases the risk for depressive symptoms in pregnancy.</p><p>Methods: Women were recruited during their ultrasound screening in gestational ...
Metformin in Pregnancy Study (MiPS): Protocol for a systematic review with individual patient data meta-analysis
<p>Abstract</p><p>Introduction Gestational diabetes mellitus (GDM) is a common disorder of pregnancy and contributes to adverse pregnancy outcomes. Metformin is often used for the prevention and management of GDM; however, ...
Body composition measurement by air displacement plethysmography in pregnancy: Comparison of predicted versus measured thoracic gas volume
<div><h3>Objectives</h3><p>Body
composition measurements with air displacement plethysmography (ADP)
define body volume, which must be corrected for thoracic gas volume
(TGV). We hypothesized that physiologic changes owing to pregnancy could
affect the accuracy of predicted TGV and introduce errors into body
composition measurements.</p></div><div><h3>Methods</h3><p>We
investigated the effect of measuring versus predicting TGV on the
accuracy of body composition calculations measured with ADP in
overweight and obese pregnant women. The fat and fat-free masses of 110
women were determined with ADP with predicted and measured TGV.</p></div><div><h3>Results</h3><p>Measured TGV decreased from early to late pregnancy (P = 0.0002).
Compared with measured TGV, predicted TGV was 6.3% higher during early
gestation and 12.6% higher during late gestation (both P ≤
0.001). The use of predicted instead of measured TGV in body composition
calculations resulted in an overestimation of fat mass by 0.8% during
the early stage, and 2.6% during the late stage of pregnancy (both P ≤ 0.001).</p></div><div><h3>Conclusions</h3><p>Measuring
TGV increases the accuracy of body composition measurement by ADP in
overweight and obese women, particularly during the late stage of
pregnancy.</p></div>...
PRISM: Recovering cell type specific expression profiles from individual composite RNA-seq samples
<p><strong>Motivation: </strong>A major challenge in analyzing cancer patient transcriptomes is that the tumors are inherently heterogeneous and evolving. We analyzed 214 bulk RNA samples of a longitudinal, prospective ...
A longitudinal analysis of CA125 glycoforms in the monitoring and follow up of high grade serous ovarian cancer
<div><h3>Objective</h3><p>Cancer antigen 125 (CA125) is generally considered the gold standard of biomarkers in the diagnosis and monitoring of high grade serous ovarian carcinoma (HGSC). We recently reported, that two CA125 glycoforms (CA125-STn and CA125-MGL) have a high specificity to HGSC and further hypothesized, that these cancer specific glycoforms are feasible candidates as biomarkers in HGSC treatment and follow up.</p></div><div><h3>Methods</h3><p>Our cohort consisted of 122 patients diagnosed with HGSC. Serum samples were collected longitudinally at the time of diagnosis, during treatment and follow up. Serum levels of CA125, CA125-STn and CA125-MGL were determined and compared or correlated with different end points (tumor load assessed intraoperatively, residual disease, treatment response, progression free survival).</p></div><div><h3>Results</h3><p>Serum CA125-STn levels at diagnosis differentiated patients with low tumor load and high tumor load (p = 0,030), indicating a favorable detection of tumor volume. Similarly, the CA125-STn levels at diagnosis were significantly lower in patients with subsequent complete cytoreduction than in patients with suboptimal cytoreduction (p = 0,025). Conventional CA125 did not differentiate these patients (p = 0,363 and p = 0,154). The CA125-STn nadir value predicted the progression free survival of patients. The detection of disease relapse was improved with CA125-STn, which presented higher fold increase in 80,0% of patients and earlier increase in 37,0% of patients.</p></div><div><h3>Conclusions</h3><p>CA125-STn showed promise as a useful biomarker in the monitoring and follow up of patients with HGSC utilizing a robust and affordable technique. Our findings are topical as a suitable indicator of tumor load facilitates patient selection in an era of new targeted therapies.</p></div>...