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Experimental and Human Evidence for Lipocalin-2 (Neutrophil Gelatinase-Associated Lipocalin [NGAL]) in the Development of Cardiac Hypertrophy and heart failure

Kettunen J; Patel SK; Soininen P; Lehtimaki T; Bell JR; McGlynn M; Charchar FJ; Wai B; Burrell LM; Raitakari O; Kahonen M; Lewandowski PA; Booth SA; Raitoharju E; Delbridge LM; Wurtz P; Curl CL; Kelly J; Ritchie SC; Wlodek ME; Byars SG; Havulinna A; Ruohonen S; Berzins SP; Minoda Y; Harrap SB; Marques FZ; Kangas AJ; Inouye M; Salomaa V; Srivastava PM; Rana I; Perola M; Prestes PR; Ala-Korpela M

Background-Cardiac hypertrophy increases the risk of developing heart failure and cardiovascular death. The neutrophil inflammatory protein, lipocalin-2 (LCN2/NGAL), is elevated in certain forms of cardiac hypertrophy and ...

Epigenome-450K-wide methylation signatures of active cigarette smoking: The Young Finns Study

Raitoharju E; Lehtimaki T; Mishra BH; Holm L; Marttila S; Kahonen M; Toronen P; Mononen N; Hanninen I; Mishra PP; Hurme M; Raitakari O

Smoking as a major risk factor for morbidity affects numerous regulatory systems of the human body including DNA methylation. Most of the previous studies with genome-wide methylation data are based on conventional association ...

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Harris TB; Tuomilehto J; Harder MN; James AL; Silbernagel G; Hutri-Kahonen N; Rudan I; Navarro P; Mahajan A; Kolcic I; Kutalik Z; Jackson AU; Balkau B; Marten J; Rankinen T; Stott DJ; Bandinelli S; Liu CT; Schlessinger D; Bien SA; Vestergaard H; Direk N; Holmen OL; van der Laan SW; Alfred T; Scholtens S; Marques-Vidal P; Olden M; Fisher VA; Hocking LJ; Kleber ME; Frayling TM; Eicher JD; Launer LJ; Lim U; Xue L; Lee NR; Lehtimaki T; Metspalu A; Rao DC; Jarvelin MR; Pervjakova N; Rasmussen-Torvik LJ; Chittani M; Strauch K; Lindgren CM; Qi L; Bergmann S; Volzke H; Heid IM; Strachan DP; Hottenga JJ; Hansen T; Haitjema S; Sorensen TIA; Kuh D; Bergman RN; Pasterkamp G; Sennblad B; McCarthy MI; Gong J; Nauck M; Bartz TM; Waeber G; Chasman DI; Strawbridge RJ; Dedoussis G; Justice AE; Wild S; Faul JD; Taylor KD; Chu AY; Hollensted M; Vedantam SL; Raitakari OT; Rauramaa R; Loh M; Eriksson J; Justesen JM; Savonen K; Cupples LA; Borecki IB; Fox CS; Hastie ND; Kivimaki M; Gudnason V; Heath AC; Narisu N; Madden PAF; Mohlke KL; Pisinger C; Wu Y; Eiriksdottir G; Barroso I; Perez J; Musk AW; Heard-Costa NL; Ludolph-Donislawski A; Lind L; Bonnycastle LL; Tyrrell J; Bragg J; Zhao W; Kvaloy K; Hassinen M; Lim E; Rice T; Hadley D; Froguel P; Winkler TW; Padmanabhan S; Gorski M; Chambers JC; Weir DR; Grabe HJ; Hirschhorn JN; Barata L; Curran JE; Campbell H; Peters U; Boehnke M; Peters A; Deng X; Langenberg C; Wilson JF; Loos RJF; de Borst GJ; Zubair N; Marchini J; Tayo BO; Afzal U; Hamsten A; Deloukas P; Hindorff L; Esko T; Chen YDI; Cusi D; Baldassarre D; Palmer LJ; Mellstrom D; Hayward C; de Faire U; Wright AF; Grallert H; Glorioso N; Scott RA; Linneberg A; Kinnunen L; Sarti C; Collins FS; Lorentzon M; Hernandez D; Spector TD; Forrester T; Schurmann C; Hung J; Luben R; Zhang WH; Grammer TB; Smith JA; Middelberg RPS; Smith BH; Oldehinkel AJ; Bielak LF; Johnson AD; Boomsma DI; Jhun MA; Vink JM; Stringham HM; Ingelsson E; Marz W; Zillikens MC; Bakker SJL; North KE; Kramer BK; Gigante B; Jansson JO; Huang J; Kooner JS; Graff M; Bonnefond A; Kardia SLR; Jorgensen ME; Kahonen M; Vonk JM; Polasek O; Ong KK; Corre T; Vollenweider P; Morris AP; Perusse L; Gertow K; Hveem K; Tiemeier H; Franks PW; Slagboom PE; Zimmermann ME; Martin NG; Sanna S; Biffar R; Bottinger E; Ohlsson C; McKnight B; Czajkowski J; Hunter DJ; Stancakova A; Horikoshi M; van der Most PJ; Verweij N; Thuillier D; Komulainen P; Ridker PM; Boerwinkle E; Peyser PA; Waldenberger M; Ferrucci L; Van Vliet-Ostaptchouk JV; Chines PS; Van der Harst P; Staessen JA; Psaty BM; Delgado GE; Rose LM; Afaq S; Eriksson AL; Hartman CA; Boger CA; Beilby J; Grarup N; Adair LS; Young K; Mannikko R; Haiman CA; van Duijn CM; Sarzynski MA; Mueller-Nurasyid M; Ford I; Manichaikul A; Huang T; Rawal R; Amin N; Westendorp RGJ; Nolte IM; Wolffenbuttel BHR; Koistinen HA; Swertz MA; Wu J; Laakso M; Smith AV; Montgomery GW; Fischer K; Willemsen G; Wong A; Le Marchand L; Leander K; Blangero J; Whitfield JB; Ahmad S; Buyske S; Menni C; Cadby G; Gordon-Larsen P; Lupoli S; Vandenput L; Kanoni S; Kumari M; Braga D; Feitosa MF; den Ruijter HM; Jukema W; Sung YJ; Bouchard C; Hallmans G; Thorand B; Abecasis GR; Karlsson M; de Craen AJM; Vitart V; Porteous DJ; Siemelink MA; Qi QB; Lobbens S; Uitterlinden AG; Kolovou G; Tanaka T; McKenzie CA; Lubke G; Kooperberg C; Snieder H; Zhao JH; Ahluwalia TS; Homuth G; Luan J; Cucca F; Renstrom F; Lyytikainen LP; Huffman JE; Teumer A; Swift AJ; Yengo L; Mangino M; Wareham NJ; Sattar N; Lakka TA; Kuusisto J; Buckley BM; Ngwa JS; Trompet S; Kilpelainen TO; Tremoli E; de Geus EJC; Pedersen O; Vohl MC; Juonala M; Cooper RS; Coggeshall S; Bruinenberg M

Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, ...

Blood hsa-miR-122-5p and hsa-miR-885-5p levels associate with fatty liver and related lipoprotein metabolism-The Young Finns Study

Lehtimaki T; Laaksonen R; Seppala I; Loo BM; Soininen P; Illig T; Klopp N; Raitoharju E; Raitakari O; Hutri-Kahonen N; Kahonen M; Lyytikainen LP; Leiviska J; Ala-Korpela M; Waldenberger M; Oksala N; Kangas AJ; Viikari J

MicroRNAs are involved in disease development and may be utilized as biomarkers. We investigated the association of blood miRNA levels and a) fatty liver (FL), b) lipoprotein and lipid pathways involved in liver lipid ...

Genome-Wide Meta-Analysis of Sciatica in Finnish Population

Lemmela S; Kettunen J; Husgafvel-Pursiainen K; Heliovaara M; Solovieva S; Viikari J; Perola M; Shiri R; Ripatti S; Raitakari OT; Anttila V; Juonala M; Kahonen M; Benner C; Salomaa V; Palotie A; Seppala I; Viikari-Juntura E; Lehtimaki T

Sciatica or the sciatic syndrome is a common and often disabling low back disorder in the working-age population. It has a relatively high heritability but poorly understood molecular mechanisms. The Finnish population is ...

CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits

Cusi D; Franke L; Noukas M; Raitakari OT; Perola M; Kutalik Z; Sinisalo J; Reymond A; Koponen P; Loos RJF; Sapkota Y; Yaghootkar H; Oldehinkel AJ; Geller F; Lokki ML; Metspalu A; Chambers JC; Porcu E; Nolte IM; Wain LV; Jacquemont S; Strachan DP; Sparso T; Ang WQ; Kahonen M; Feitosa MF; Perls TT; Wood AR; Mannik K; Lundqvist A; Rissanen H; Salvi E; Snieder H; Palotie A; Bottinger EP; Venturini C; Lehtimaki T; Beaumont RN; Koskinen S; Wray NR; Hirschhorn J; Kriebel J; Mannisto S; Heid IM; Werge T; Shrine N; Hansen TF; Meitinger T; Beckmann JS; Lettre G; Schick U; Peters A; Deloukas P; Ruth KS; Newman AB; Wojczynski MK; Boers H; Lenzini P; Frayling TM; Nieminen M; Afaq S; Liu XP; Martin NG; Medland SE; Tyrrell J; Kristiansson K; Melbye M; Mattsson H; Christensen K; Porteous D; Feenstra B; Kooner JS; Muller-Nurasyid M; Magi R; Deelen P; Freathy RM; van der Most PJ; Salomaa V; Hayward C; Viikari JS; Schupf N; Nyholt DR; Winkler TW; Jones SE; Zhang WH; Spector TD; Havulinna AS; Lahti J; Bochud M; Eriksson JG; Rueger S; Province MA; Tobin MD; Weedon MN; Rivadeneira F; Vartiainen E; Tuke MA; Mangino M; Swertz MA; McDaid AF; Montgomery GW; Murray A; Rosengren A; Pennell C; Borodulin K; Mace A

There are few examples of robust associations between rare copy number variants (CNVs) and complex continuous human traits. Here we present a large-scale CNV association meta-analysis on anthropometric traits in up to ...

Exposure to parental smoking and cardiac structure and function in adulthood: the Cardiovascular Risk in Young Finns Study

Ruohonen S; Pahkala K; Magnussen CG; Burgner DP; Laitinen TP; Tossavainen P; Kahonen M; Nuotio J; Taittonen L; Pihlman J; Jokinen E; Hutri-Kahonen N; Rovio S; Raitakari OT; Viikari JSA; Juonala M

<p><strong>Background and aims: </strong>The relationship between childhood tobacco smoke exposure and cardiac structure and function in midlife is unclear. We investigated the association between parental smoking with ...

PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity

Polasek O; Arnar DO; Tarasov KV; Boerwinkle E; Samani NJ; Pramstaller PP; Lin HJ; Butler AM; Avery CL; Ulivi S; Trompet S; Parsa A; de Bakker PIW; Macfarlane PW; Verweij N; Ritchie MD; Lin HH; Hayward C; Krijthe BP; Volzke H; Lyytikainen LP; Spector TD; Heckbert SR; Ehret GB; Barnard J; Soliman EZ; Gharib SA; Strauch K; Gasparini P; Sinagra G; Hicks AA; Munzel T; Felix SB; Bis J; Eijgelsheim M; Asselbergs FW; Roden DM; Kerr KF; Rudan I; Psaty BM; Benjamin EJ; Gudbjartsson DF; Snieder H; Liu YM; Wilson JF; Thorsteinsdottir U; Waldenberger M; Stricker BH; Teumer A; Schnabel RB; Muller-Nurasyid M; Buckley BM; van der Harst P; Steri M; Jukema JW; Alonso A; Loos RJF; Lehtimaki T; Smith AV; Campbell H; Pfeufer A; Nolte IM; Westra HJ; Jamshidi Y; Padmanabhan S; Yin XY; Mitchell BD; Uitterlinden AG; Arking DE; Sinner MF; Van Wagoner DR; Ferrucci L; Lubitz SA; Bradford Y; Aldana CTS; Launer LJ; van Setten J; Magnani JW; Isaacs A; Crawford D; Cucca F; Volker U; Ilaria G; Dorr M; Raitakari OT; Peters A; Gudnason V; Lakatta EG; Evans DS; Swenson BR; Zeller T; Stott DJ; Papanicolaou GJ; Kors JA; Schlessinger D; Del Greco FM; Munroe PB; Leach IM; Kaab S; Gibson Q; Bandinelli S; Blankenberg S; Kahonen M; Robino A; Brody JA; Dominiczak AF; den Hoed M; Wild PS; Sotoodehnia N; Holm H; van Duijn CM; Stefansson K; Harris TB; Bader JS; Iorio A; Tanaka T; Franke L; Rotter JI; Meitinger T; Denny JC; Smith JD; Muller C; Chung MK; Franco OH; Kolcic I; Ellinor PT

Electrocardiographic PR interval measures atrio-ventricular depolarization and conduction, and abnormal PR interval is a risk factor for atrial fibrillation and heart block. Our genomewide association study of over 92,000 ...

DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases

Brenner H; Kasela S; Sotoodehnia N; Smith AK; Relton C; Doerr M; Wielscher M; Robinson O; Psaty BM; Baccarelli AA; Selvin E; Deloukas P; van Meurs JBJ; Marouli E; Mustafa R; Ghanbari M; Bell JT; Kahonen M; Krogh V; Teumer A; Levy D; Waldenberger M; Chambers JC; Brody JA; van der Harst P; Panico S; Colicino E; Hurme MA; Bis JC; Peters A; Guan WH; Karhunen V; Chen W; Kottgen A; Torres MA; Matullo G; Cardona A; Lehne B; Bodinier B; Nauck M; Tumino R; Fiorito G; Dehghan A; Verweij N; Schlosser P; Iacoviello L; Marioni RE; Kuehnel B; Graf-Schindler J; Kooner JS; Beekman M; Fisher K; Koenig W; Chadeau-Hyam M; Milani L; Tzala E; Vineis P; Waite LL; Lehtimaki T; Jarvelin MR; Conneely KN; Farlik M; Heijmans BT; Palaniswamy S; Deary IJ; Mandaviya PR; Rathmann W; Miller AH; Gao X; Herzig KH; Ong KK; Elliott P; Walton E; Cugliari G; Joehanes R; Zhang Y; Raitakari OT; Boerwinkle E; Wilson R; Loh M; Xia YJ; Grabe HJ; Tsai PC; Li SX; Mishra PP; Weninger W; Zhang T; Tanaka T; Sacerdote C

Chronic inflammation, marked by C-reactive protein, has been associated with changes in methylation, but the causal relationship is unclear. Here, the authors perform a Epigenome-wide association meta-analysis for C-reactive ...

Vitamin D and cognitive function: A Mendelian randomisation study

Pedersen NL; Kuzma E; Singh-Manoux A; Brenner H; Karhunen V; Cavadino A; Hutri-Kahonen N; Zhan YQ; Kilander L; Power C; Kjaergaard M; Raitakari OT; Lehtimaki T; Sen A; Herzig KH; Byberg L; Hypponen E; Zhou A; Lind L; Kivimaki M; Schmidt H; Eriksson JG; Jarvelin MR; Maddock J; Hagg S; Ingelsson E; Perna L; Guessous I; Melhus H; Michaelsson K; Schottker B; Engmann J; Schirmer H; Jorde R; Vollenweider P; Marques-Vidal P; Kumari M; Lahti J; Smart MC; Petrovic KE; Kahonen M; Saum KU; Rovio SP; Auvinen J; Llewellyn DJ; Raikkonen K; Bao YC; Schmidt R; Veijola J

The causal nature of the association between hypovitaminosis D and poor cognitive function in mid-to later-life is uncertain. Using a Mendelian randomisation(MR) approach, we examined the causal relationship between 25(OH)D ...