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Key factors supporting implementation of a training program for neonatal family- centered care - a qualitative study
<p>Background</p><p>Traditionally, the care of infants in neonatal care units has been professionally centered, paying less attention to family support. In recent years, many interventions have been developed to improve ...
Heterozygous loss of function of IQSEC2/Iqsec2 leads to increased activated Arf6 and severe neurocognitive seizure phenotype in females
Clinical presentations of mutations in the IQSEC2 gene on the X-chromosome initially implicated to cause non-syndromic intellectual disability (ID) in males have expanded to include early onset seizures in males as well ...
Hypogonadism and Cryptorchidism
Congenital cryptorchidism (undescended testis) is one of the most common congenital urogenital malformations in boys. Prevalence of cryptorchidism at birth among boys born with normal birth weight ranges from 1.8 to 8.4%. ...
First-emerging islet autoantibody and glucose metabolism: search for type 1 diabetes subtypes
<p>Objective<br></p><p>Subtypes in type 1 diabetes pathogenesis have been implicated based on the first-appearing autoantibody (primary autoantibody). We set out to describe the glucose metabolism in preclinical diabetes ...
Nuoruusiän idiopaattinen skolioosi
Nuoruusiän idiopaattinen skolioosi on tavallisin hoitoa vaativa lasten selkäsairaus. Valtaosalla skolioosi todetaan kouluterveydenhuollon terveystarkastuksen yhteydessä. Skolioosin varhainen toteaminen on korsettihoidon ...
The Development of Data Collection Tools to Measure Parent-Infant Closeness and Family-Centered Care in NICUs
Background Preterm and sick infants benefit from parent-infant closeness and family-centered care (FCC) in neonatal intensive care units (NICUs). Prospective and feasible tools are needed to measure these care practices ...
Lysinuurinen proteiini-intoleranssi
Lysinuurinen proteiini-intoleranssi (LPI) on harvinainen suomalaiseen tautiperintöön kuuluva arginiinin, ornitiinin ja lysiinin kuljetushäiriö suolen ja munuaistiehyiden solukalvoilla. Arginiinin ja ornitiinin puute aiheuttaa ...
Myxovirus Resistance Protein A as a Marker of Viral Cause of Illness in Children Hospitalized with an Acute Infection
<p>A biomarker for viral infection could improve the differentiation between viral and bacterial infections and reduce antibiotic overuse. We examined blood myxovirus resistance protein A (MxA) as a biomarker for viral infections in children with an acute infection. We recruited 251 children presenting with a clinical suspicion of serious bacterial infection, determined by need for a blood bacterial culture collection, and 14 children with suspected viral infection at two pediatric emergency departments. All children were aged between 4 weeks and 16 years. We classified cases according to the viral, bacterial, or other etiology of the final diagnosis. The ability of MxA to differentiate between viral and bacterial infections was assessed. The median blood MxA levels were 467 (interquartile range, 235 to 812) μg/L in 39 children with a viral infection, 469 (178 to 827) μg/L in 103 children with viral-bacterial coinfection, 119 (68 to 227) μg/L in 75 children with bacterial infection, and 150 (101 to 212) μg/L in 26 children with bacterial infection and coincidental virus finding (P < 0.001). In a receiver operating characteristics analysis, MxA cutoff level of 256 μg/L differentiated between children with viral and bacterial infections with an area under the curve of 0.81 (95% confidence interval [CI] = 0.73 to 0.90), a sensitivity of 74.4%, and a specificity of 80.0%. In conclusion, MxA protein showed moderate accuracy as a biomarker for symptomatic viral infections in children hospitalized with an acute infection. High prevalence of viral-bacterial coinfections supports the use of MxA in combination with biomarkers of bacterial infection.<br></p>...
Early-life exposure to perfluorinated alkyl substances modulates lipid metabolism in progression to celiac disease
<p>Celiac disease (CD) is a systemic immune-mediated disorder with increased frequency in the developed countries over the last decades implicating the potential causal role of various environmental triggers in addition ...