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Aineistot 31-40 / 4137
The association of diabetes-related self-care activities with perceived stress, anxiety, and fatigue: a cross-sectional study
Purpose: Many people with type 2 diabetes (T2DM) do not sustain sufficient diabetes-related self-care activities (DRSCA) in their daily lives. To provide additional information about the positive influence of DRSCA, this ...
Polymorphisms of toll-like receptors 2 and 9 and severity and prognosis of bacterial meningitis in Chinese children
Toll-like receptors (TLRs) play a crucial role in innate immunity, protecting the host from bacterial pathogens. We investigated whether bacterial meningitis (BM) in children was associated with gene polymorphisms in TLR2 ...
The Pursuit of Effective Working Memory Training: a Pre-registered Randomised Controlled Trial with a Novel Varied Training Protocol
<p> Working memory (WM) training, typically entailing repetitive practice with one or two tasks, has mostly yielded only limited task-specific transfer effects. We developed and tested a new WM training approach where the task paradigm, stimulus type, and predictability of the stimulus sequence were constantly altered during the 4-week training period. We expected that this varied training protocol would generate more extensive transfer by facilitating the use of more general strategies that could be applied to a range of WM tasks. Pre-post transfer effects following varied training (VT group, n = 60) were compared against traditional training (TT group, training a single adaptive WM task, n = 63), and active controls (AC, n = 65). As expected, TT evidenced strong task-specific near transfer as compared to AC. In turn, VT exhibited task-specific near transfer only on one of the measures, and only as compared to the TT group. Critically, no evidence for task-general near transfer or far transfer effects was observed. In sum, the present form of VT failed to demonstrate broader transfer. Nevertheless, as VT has met with success in other cognitive domains, future studies should probe if and how it would be possible to design WM training protocols that promote structural learning where common features of specific tasks would be identified and utilised when selecting strategies for novel memory tasks. <br></p>...
Are Quantitative Errors Reduced with Time-of-Flight Reconstruction When Using Imperfect MR-Based Attenuation Maps for F-18-FDG PET/MR Neuroimaging?
<p>We studied whether TOF reduces error propagation from attenuation correction to PET image reconstruction in PET/MR neuroimaging, by using imperfect attenuation maps in a clinical PET/MR system with 525 ps timing resolution. ...
Long-Term Outcomes of Surgical Aortic Valve Replacement in Patients with Rheumatoid Arthritis
Background: Patients with rheumatoid arthritis (RA) have increased risk of developing cardiovascular disease and events. Little is, however, known about the influence of RA to the outcomes after surgical aortic valve ...
AAV2-VEGF-B gene therapy failed to induce angiogenesis in ischemic porcine myocardium due to inflammatory responses
<p>Therapeutic angiogenesis induced by gene therapy is a promising approach to treat patients suffering from severe coronary artery disease. In small experimental animals, adeno-associated viruses (AAVs) have shown good ...
Mitä uutta Ewingin sarkooman hoidossa?
<p>Ewingin sarkooma on pääasiassa luustossa esiintyvä lasten ja nuorten aikuisten harvinainen pahanlaatuinen kasvain. Paikallisen taudin yhteydessä viiden vuoden elossaolo-osuus ilman paikallista uusiutumaa tai metastasointia on noin 75 %. Etäpesäkkeitä todetaan diagnoosivaiheessa 25 %:lla potilaista, ja heidän ennusteensa on huono. Paikallisen taudin hoidossa konventionaalisen solunsalpaajahoidon intensiivisyyttä lisäämällä ennustetta on saatu parannettua. Kantasolutuen turvin toteutettu intensiivihoito näyttää hyödyttävän potilaita, joiden vaste konventionaaliseen hoitoon on ollut huono. Kohdennetut lääkehoidot eivät vielä ole rutiinimaisia Ewingin sarkooman hoidossa. Kasvaimen resektio puhtain marginaalein on kirurgisen hoidon kulmakivi. On syytä välttää leesionsisäistä resektiota ja huolehtia paikalliskontrollista sädehoidolla, mikäli radikaali resektio ei ole mahdollinen. Protonihoitoa tulee harkita lantion, vartalon sekä pään ja kaulan kasvainten yhteydessä haittojen vähentämiseksi. Kasvain-DNA:n määrän mittaaminen verestä auttaa ennusteen arvioinnissa, mutta menetelmä ei ole vielä rutiinikäytössä Suomessa.<br /></p>...