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The macrophage mannose receptor regulate mannan-induced psoriasis, psoriatic arthritis, and rheumatoid arthritis-like disease models
<p>The injection of mannan into mice can result in the development of
psoriasis (Ps) and psoriatic arthritis (PsA), whereas co-injection with
antibodies toward collagen type II leads to a chronic rheumatoid-like ...
Effects of Different Exercise Training Protocols on Gene Expression of Rac1 and PAK1 in Healthy Rat Fast- and Slow-Type Muscles
Purpose Rac1 and its downstream target PAK1 are novel regulators of insulin and exercise-induced glucose uptake in skeletal muscle. However, it is not yet understood how different training intensities affect the expression ...
Nonclinical Characterization of Bexmarilimab, a Clever-1-Targeting Antibody for Supporting Immune Defense Against Cancers
Common lymphatic endothelial and vascular endothelial receptor-1 (Clever-1) is a multifunctional type-1 transmembrane protein that plays an important role in immunosuppression against tumors. Clever-1 is highly expressed ...
Human liver sinusoidal endothelial cells promote intracellular crawling of lymphocytes during recruitment: A new step in migration
The recruitment of lymphocytes via the hepatic sinusoidal channels and positioning within liver tissue is a critical event in the development and persistence of chronic inflammatory liver diseases. The hepatic sinusoid is ...
[Ga-68]Ga-DOTA-Siglec-9 Detects Pharmacodynamic Changes of FAP-Targeted IL2 Variant Immunotherapy in B16-FAP Melanoma Mice
Vascular adhesion protein-1 (VAP-1) is an inflammation-inducible adhesion molecule, which supports contact between leukocytes and inflamed endothelium. There is evidence that VAP-1 is involved in the recruitment of leukocytes ...
Structural Basis for the Functional Changes by EGFR Exon 20 Insertion Mutations
<div><b>Simple Summary</b></div><div>Non-small cell lung cancer (NSCLC) is the most common type of lung cancer that claims the lives of many worldwide. Activating mutations occurring on the epidermal growth factor receptor ...
Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation
Numerous somatic mutations occurring in the epidermal growth factor receptor (EGFR) family (ErbB) of receptor tyrosine kinases (RTK) have been reported from cancer patients, although relatively few have been tested and ...
Kinetic Modelling of [Ga-68]Ga-DOTA-Siglec-9 in Porcine Osteomyelitis and Soft Tissue Infections
<div>Background: [Ga-68]Ga-DOTA-Siglec-9 is a positron emission tomography (PET) radioligand for vascular adhesion protein 1 (VAP-1), a protein involved in leukocyte trafficking. The tracer facilitates the imaging of ...
Vascular adhesion protein-1 is elevated in primary sclerosing cholangitis, is predictive of clinical outcome and facilitates recruitment of gut-tropic lymphocytes to liver in a substrate-dependent manner
<h4>OBJECTIVE: </h4><p>Primary
sclerosing cholangitis (PSC) is the classical hepatobiliary
manifestation of IBD. This clinical association is linked pathologically
to the recruitment of mucosal T cells to the liver, ...
Genome-wide association study of circulating interleukin 6 levels identifies novel loci
<p>Interleukin 6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease pathogenesis. We conducted a two-staged, discovery and replication meta genome-wide association study (GWAS) of circulating serum IL-6 levels comprising up to 67428 (n<sub>discovery</sub>=52654 and n<sub>replication</sub>=14774) individuals of European ancestry. The inverse variance fixed effects based discovery meta-analysis, followed by replication led to the identification of two independent loci, IL1F10/IL1RN rs6734238 on chromosome (Chr) 2q14, (P<sub>combined</sub>=1.8x10<sup>-11</sup>), HLA-DRB1/DRB5 rs660895 on Chr6p21 (P<sub>combined</sub>=1.5x10<sup>-10</sup>) in the combined meta-analyses of all samples. We also replicated the IL6R rs4537545 locus on Chr1q21 (P<sub>combined</sub>=1.2x10<sup>-122</sup>). Our study identifies novel loci for circulating IL-6 levels uncovering new immunological and inflammatory pathways that may influence IL-6 pathobiology.</p>...