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Aineistot 31-40 / 42
Childhood manifestations of 22q11.2 deletion syndrome: A Finnish nationwide register-based cohort study
<p>Aim<br>The aim of the study was to describe the clinical manifestations of 22q11.2 deletion syndrome patients in the Finnish paediatric population.</p><p>Methods<br>Nationwide registry data including all diagnoses and ...
Patterning of educational attainment across inflammatory markers: Findings from a multi-cohort study
Background: Evidence suggests that the inflammatory reaction, an adaptive response triggered by a variety of harmful stimuli and conditions involved in the risk and development of many chronic diseases, is a potential ...
The Role of Inflammatory Cytokines as Intermediates in the Pathway from Increased Adiposity to Disease
<p>Objective <br></p><p>This study aimed to investigate the role of cytokines as intermediates in the pathway from increased adiposity to disease.<br></p><p>Methods <br></p><p>BMI and circulating levels of up to 41 cytokines ...
Accuracy of echocardiographic area-length method in chronic myocardial infarction: comparison with cardiac CT in pigs
Background: We evaluated echocardiographic area-length methods to measure left ventricle (LV) volumes and ejection fraction (EF) in parasternal short axis views in comparison with cardiac computed tomography (CT) in pigs ...
Genome-wide association study identifies seven novel loci associating with circulating cytokines and cell adhesion molecules in Finns
<p>Background: Inflammatory processes contribute to the pathophysiology of multiple chronic conditions. Genetic factors play a crucial role in modulating the inflammatory load, but the exact mechanisms are incompletely ...
Determining the timing of pubertal onset via a multicohort analysis of growth
<p><strong>Objective</strong></p><p>Growth-based determination of pubertal onset timing would be cheap and practical. We aimed to determine this timing based on pubertal growth markers. Secondary aims were to estimate the ...
Childhood exposure to parental smoking and life-course overweight and central obesity
<p><strong>Objective: </strong>To evaluate the association between childhood parental smoking exposure and the risk of overweight/obesity from childhood to adulthood.</p><p><strong>Methods: </strong>This study leverages ...
Epigeneettinen periytyminen sukusolulinjassa
Ympäristön aiheuttamat muutokset geenien toiminnassa voivat periytyä sukupolvelta toiselle sukusolujen välityksellä ja vaikuttaa näin jälkikasvun fenotyyppiin, ilman että {DNA}:n emäsjärjestyksessä tapahtuu muutoksia. ...
Evaluation of 68Ga-labeled peptide tracer for detection of gelatinase expression after myocardial infarction in rat
<h4>BACKGROUND: </h4><p>Matrix metalloproteinases 2 and 9 (MMP-2/9) play a role in extracellular matrix remodeling after an ischemic myocardial injury. We evaluated 68Ga-DOTA-peptide targeting MMP-2/9 for the detection of ...
Two weeks of moderate-intensity continuous training, but not high-intensity interval training, increases insulin-stimulated intestinal glucose uptake
<p>Similar to muscles, the intestine is also insulin resistant in obese subjects and subjects with impaired glucose tolerance. Exercise training improves muscle insulin sensitivity, but its effects on intestinal metabolism ...