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Genetic architecture of human plasma lipidome and its link to cardiovascular disease
Understanding genetic architecture of plasma lipidome could provide better insights into lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome-wide association analyses of 141 lipid species ...
Occlusal traits of 4–5-year-old Estonians. Parents' perception of orthodontic treatment need and satisfaction with dental appearance
<p>This study aims to evaluate the prevalence of occlusal traits and to assess parents'/caregivers' satisfaction with child's dental appearance and perception of orthodontic treatment need in 4–5‐year‐old Estonians. Clinical ...
Genomic prediction of alcohol-related morbidity and mortality
While polygenic risk scores (PRS) have been shown to predict many diseases and risk factors, the potential of genomic prediction in harm caused by alcohol use has not yet been extensively studied. Here, we built a novel ...
Xylo-Oligosaccharides in Prevention of Hepatic Steatosis and Adipose Tissue Inflammation: Associating Taxonomic and Metabolomic Patterns in Fecal Microbiomes with Biclustering
We have shown that prebiotic xylo-oligosaccharides (XOS) increased beneficial gut microbiota (GM) and prevented high fat diet-induced hepatic steatosis, but the mechanisms associated with these effects are not clear. We ...
Successful suppression of musical hallucinations with low-frequency rTMS of the left temporo-parietal junction: A case report
<p><br></p><p>Background: Inhibitory low frequency repetitive transcranial magnetic stimulation (rTMS) of the temporo-parietal area has been applied to treat both auditory verbal hallucinations as well as tinnitus.<br></ ...
Pim kinases are upregulated during Epstein-Barr virus infection and enhance EBNA2 activity
Latent Epstein-Barr virus (EBV) infection is strongly associated with B-cell proliferative diseases such as Burkitt's lymphoma. Here we show that the oncogenic serine/threonine kinases Pim-1 and Pim-2 enhance the activity ...
Trends in presentation, treatment and survival of 1777 patients with colorectal cancer over a decade: a Biobank study
<p><b>Background:</b>
Most survival data in colorectal cancer (CRC) is derived from clinical
trials or register-based studies. Hospital Biobanks, linked with
hospital electronic records, could serve as a data-gathering ...
Autoimmunity, hypogammaglobulinemia, lymphoproliferation and mycobacterial disease in patients with dominant activating mutations in STAT3
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The signal transducer and activator of transcription (STAT) family of transcription factors orchestrate hematopoietic cell differentiation. Recently, mutations in STAT1, STAT5B, and STAT3 have been linked to development ...
An age- and sex-specific dietary guidelines index is a valid measure of diet quality in an Australian cohort during youth and adulthood
Measuring diet quality over time is important due to health impacts, but to our knowledge, a Dietary Guidelines Index (DGI) with consistent scoring across childhood/adolescence (youth) and adulthood has not been validated. ...