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Interactions of genetic variants and prenatal stress in relation to the risk for recurrent respiratory infections in children
<p>Genetic variants may predispose children to recurrent respiratory
infections (RRIs) but studies on genotype-environment interaction are
rare. We hypothesized that the risk for RRIs is elevated in children
with ...
Lapsen epäselvän sukupuolen diagnostiikka ja hoito
Kun vastasyntyneen sukupuolta ei pystytä heti tunnistamaan, häneltä tulee sulkea pois hengenvaarallinen lisämunuaisten vajaatoimintaan johtava virilisoiva lisämunuaishyperplasia ja tarvittaessa aloittaa siihen gluko- ja ...
Simulating Screening for Risk of Childhood Diabetes: The Collaborative Open Outcomes tooL (COOL)
<p>The Collaborative Open Outcomes tooL (COOL) is a novel, highly configurable application to simulate, evaluate and compare potential population-level screening schedules. Its first application is type 1 diabetes (T1D) ...
Gut Microbiota and Serum Metabolome in Elite Cross-Country Skiers: A Controlled Study
Exercise has been shown to affect gut the microbiome and metabolic health, with athletes typically displaying a higher microbial diversity. However, research on the gut microbiota and systemic metabolism in elite athletes ...
Pubarche and Gonadarche Onset and Progression Are Differently Associated With Birth Weight and Infancy Growth Patterns
<p>Context: Controversy exists regarding associations between early-life growth patterns and timing of puberty.<br></p><p>Objective: This work aims to investigate associations between birth anthropometry, early growth ...
Temporal changes in gastrointestinal fungi and the risk of autoimmunity during early childhood: the TEDDY study
<p>Fungal infections are a major health problem that often begin in the gastrointestinal tract. Gut microbe interactions in early childhood are critical for proper immune responses, yet there is little known about the ...
Diet, perceived intestinal well-being and compositions of fecal microbiota and short chain fatty acids in oat-using subjects with celiac disease or gluten sensitivity
<div>A gluten-free diet may result in high fat and low fiber intake and thus lead to unbalanced microbiota. This study characterized fecal microbiota profiles by 16S MiSeq sequencing among oat-using healthy adult subjects (n = 14) or adult subjects with celiac disease (CeD) (n = 19) or non-celiac gluten sensitivity (NCGS) (n = 10). Selected microbial metabolites, self-reported 4d food diaries and perceived gut symptoms were compared. Subjects with NCGS experienced the highest amount of gut symptoms and received more energy from fat and less from carbohydrates than healthy and CeD subjects. Oat consumption resulted in reaching the lower limit of the recommended fiber intake. Frequent consumption of gluten-free pure oats did not result in microbiota dysbiosis in subjects with CeD or NCGS. Thus, the high number of gut symptoms in NCGS subjects was not linked to the microbiota. The proportion of fecal acetate was higher in healthy when compared to NCGS subjects, which may be linked to a higher abundance of Bifidobacterium in the control group compared to NCGS and CeD subjects. Propionate, butyrate and ammonia production and β-glucuronidase activity were comparable among the study groups. The results suggest that pure oats have great potential as the basis of a gluten-free diet and warrant further studies in minor microbiota disorders. <a href="https://www.mdpi.com/2072-6643/12/9/2570/htm">View Full-Text</a></div><div>Keywords: <a href="https://www.mdpi.com/search?q=oats">oats</a>; <a href="https://www.mdpi.com/search?q=celiac disease">celiac disease</a>; <a href="https://www.mdpi.com/search?q=non-celiac gluten sensitivity">non-celiac gluten sensitivity</a>; <a href="https://www.mdpi.com/search?q=intestinal microbiota">intestinal microbiota</a>; <a href="https://www.mdpi.com/search?q=gluten-free">gluten-free</a>; <a href="https://www.mdpi.com/search?q=SCFAs">SCFAs</a></div>...