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Aineistot 81-88 / 88
The majority of type 2 diabetic patients in Finnish primary care are at very high risk of cardiovascular events: A cross-sectional chart review study (STONE HF).
<p>Aims<br></p><p>To characterize clinical profiles, prevalence of chronic kidney disease (CKD), and treatment patterns in type 2 diabetes (T2D) and heart failure (HF) patients in Finnish primary care.<br></p><p>Methods< ...
Haploinsufficiency of the NF1 gene is associated with protection against diabetes
<p>Abstract
Background The hereditary predisposition to diabetes
is only partially explained by genes identified so far.
Neurofibromatosis type 1 (NF1) is a rare monogenic
dominant syndrome caused by aberrations of the ...
Electric field-navigated transcranial magnetic stimulation for chronic tinnitus: a randomized, placebo-controlled study
Objective: Repetitive transcranial magnetic stimulation (rTMS) may alleviate tinnitus. We evaluated effects of electric field (E-field) navigated rTMS targeted according to tinnitus pitch. No controlled studies have ...
Intracranial aneurysm is predicted by abdominal aortic calcification index: A retrospective case-control study
<p>Background and aims</p><p>Patients with intracranial aneurysms (IA) have excess mortality for cardiovascular diseases, but little is known on whether atherosclerotic manifestations and IA coexist. We investigated abdominal ...
Ventral striatal dopaminergic defect is associated with hallucinations in Parkinson's disease
<h3>Conclusions</h3><p>Low striatal DAT function may predispose PD patients to VHs, and the regional distribution of the findings suggests a particular role of the ventral striatum. This is in line with non-PD research ...
Deep brain stimulation for monogenic Parkinson’s disease: a systematic review
<p>Deep brain stimulation (DBS) is an effective treatment for Parkinson’s disease (PD) patients with motor fluctuations and dyskinesias. The key DBS efficacy studies were performed in PD patients with unknown genotypes; however, given the estimated monogenic mutation prevalence of approximately 5–10%, most commonly LRRK2, PRKN, PINK1 and SNCA, and risk-increasing genetic factors such as GBA, proper characterization is becoming increasingly relevant. We performed a systematic review of 46 studies that reported DBS effects in 221 genetic PD patients. The results suggest that monogenic PD patients have variable DBS benefit depending on the mutated gene. Outcome appears excellent in patients with the most common LRRK2 mutation, p.G2019S, and good in patients with PRKN mutations but poor in patients with the more rare LRRK2 p.R1441G mutation. The overall benefit of DBS in SNCA, GBA and LRRK2 p.T2031S mutations may be compromised due to rapid progression of cognitive and neuropsychiatric symptoms. In the presence of other mutations, the motor changes in DBS-treated monogenic PD patients appear comparable to those of the general PD population.<br /></p>...
New prostate cancer grade grouping system predicts survival after radical prostatectomy
<p>Histological Gleason grading of <a title="Learn more about Prostate Cancer" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/prostate-cancer"><u>prostate cancer</u></a> has been through modifications ...