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A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

Schwarz PEH; Zhao JH; Eriksson JG; Kinnunen L; Luan JA; Raitakari OT; Kooner JS; Hassinen M; Ribel-Madsen R; Feitosa MF; Abecasis GR; Mangino M; Kanoni S; Chu AY; Wild SH; Milani L; Pankow JS; Medina-Gomez C; Oostra BA; Boehnke M; Goel A; Beilby J; Wong A; Prokopenko I; Pedersen O; Polasek O; Grewal J; Morris AP; Kajantie E; Perola M; Peters A; Hysi PG; Jokinen E; Spector TD; Mills R; Muller-Nurasyid M; Kutalik Z; Vitart V; Ohlsson C; Walker RW; Bellis C; Hui JN; Viikari JS; Justesen JM; Friedrich N; Albrecht E; Lahti J; Southam L; Tsafantakis E; Lichtner P; Hayward C; Rankinen T; Thorleifsson G; Mohlke KL; Willemsen G; Lakka TA; Hastie N; Husemoen LL; Chasman DI; McArdle WL; Watkins H; Mcknight B; Metspalu A; Palotie A; North KE; Scott RA; Cupples LA; Venturini C; Grarup N; Bragg-Gresham JL; Laitinen T; Teumer A; Ryan KA; Isaacs A; Njolstad I; Rauramaa R; Grassler J; Khaw KT; van der Harst P; Mannisto S; Salvi E; Graff M; Uitterlinden AG; Loos RJF; Bluher M; Hattersley AT; Esko T; Wang SR; Schlessinger D; Huffman JE; Kooner IK; Montasser ME; Willems SM; Bouchard C; van der Most PJ; Kolcic I; Tuomilehto J; Chambers JC; Boomsma DI; Bornstein SR; Pilia MG; Gieger C; Grallert H; Rao DC; Forouhi NG; Hansen T; Lewin AM; Heid IM; Blangero J; Palmer LJ; Fox C; Chines PS; Tonjes A; Hveem K; Penninx BW; Bonnycastle LL; Bruinenberg M; Vohl MC; Wilsgaard T; Stringham HM; Kovacs P; Oldehinkel AJ; Jarvelin MR; Ong KK; Hillege H; Harder MN; Stancakova A; Tachmazidou I; Strauch K; Monda KL; Doring A; Jackson AU; Hamsten A; Bakker SJL; Steinthorsdottir V; van Dongen J; Bergman RN; Bergmann S; Lindgren CM; Eklund N; Shudiner AR; Vartiainen E; Stefansson K; Smit JH; Van Vliet-Ostaptchouk JV; Kuusisto J; Musk AW; Lehtimaki T; Hartman CA; Frayling T; Thorsteinsdottir U; Qi L; Heliovaara M; Hottenga JJ; Salomaa V; Jorgensen T; Wright AF; Tremblay A; Knekt PB; Muller G; Holmen O; Lyssenko V; Kyriakou T; Volker U; Ferreira T; Jalilzadeh S; Jeff JM; Ridker PM; Gansevoort RT; Boerwinkle E; Borecki IB; D'Avila F; Hirschhorn JN; Magi R; Luben R; Sarzynski MA; Barlassina C; Kaplan RC; Cadby G; Ahluwalia TS; Zhang WH; Gjesing AP; Puolijoki H; Cusi D; Smith MT; Koskinen S; Widen E; Manunta P; Zillikens MC; Chiang CWK; Strachan DP; Rice TK; Winkler TW; Hofman A; Kristiansson K; Swertz MA; Koistinen HA; Sparso TH; Farrall M; Havulinna AS; Campbell H; Lindstrom J; Wilson JF; Snieder H; Sorensen TIA; Linneberg A; Uusitupa M; Dimitriou M; O'Connell JR; Eriksson J; Vollenweider P; Jula A; Zeggini E; Deloukas P; Dedoussis G; Farmaki AE; Langenberg C; Scholtens S; van Duijn CM; Mahajan A; Bartz TM; Richards M; Psaty BM; Rivadeneira F; Vandenput L; Justice AE; Cucca F; Hunter DJ; Fischer K; Jousilahti P; Homuth G; Vonk JM; Mihailov E; Perusse L; Sebert S; McCarthy MI; Heard-Costa NL; Leach IM; Nolte IM; Wareham NJ; Yerges-Armstrong LM; Ried JS; Karaleftheri M; Pramstaller PP; Pichler I; Stolk RP; Groop LC; James AL; Swift AJ; Glorioso N; Verweij N; Rose LM; Waeber G; Narisu N; Sung YJ; Rayner NW; Collins FS; Lorbeer R; Hicks AA; Sanna S; Laakso M; Chen YDI; Stirrups K; Osmond C; Paternoster L; Lorentzon M; Ittermann T; Rudan I; Hu F; de Geus EJC; Kahonen M; Gorski M; Stumvoll M; Alves AC; Kuh D; Keinanen-Kiukaanniemi SM

Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a ...

The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects

Horikoshi M; Granell R; Lichtenstein P; Kemp JP; Gilliland F; Custovic A; Henriksen TB; Mook-Kanamori DO; Santa-Marina L; Boomsma DI; Ahluwalia TS; Cavadino A; Strandberg T; Freathy RM; Snieder H; van der Most PJ; Myhre R; Larsson H; Najman JM; Eliasen AU; Almgren P; Beaumont RN; Geller F; Kaprio J; McCarthy MI; Fadista J; Lawlor DA; Frayling TM; Melbye M; St Pourcain B; Hadley D; Hypponen E; Cooper C; Feenstra B; Warrington NM; Panoutsopoulou K; Zemel BS; Liu J; Prasad RB; Cousminer DL; Coin L; Day FR; Lappe JM; Raikkonen K; Pitkanen N; Gauderman WJ; Bond T; Schnurr TM; Korner A; Xu CJ; Magnus P; Lowe WL; Grant SFA; Scott JG; Rivadeneira F; O'Reilly P; Uitterlinden AG; Morris AP; Hayes MG; Holloway JW; Yaghootkar H; Hottenga JJ; Ntalla I; Tyrrell J; Liu XP; Heinrich J; Hattersley AT; Stoltenberg C; Power C; Simpson A; Iniguez C; Kalkwarf HJ; Holt P; Koppelman GH; Middeldorp CM; Wang CA; Ong KK; Lyytikainen LP; Jarvelin MR; Henders AK; Williams GM; Kutalik Z; Standl M; Sorensen TIA; Chen ZH; Paternoster L; Vogelezang S; Yi L; Linneberg A; Sleiman PMM; Bustamante M; Hocher B; Gaillard R; Vuoksimaa E; Lundstrom S; Mahajan A; Timpson NJ; Kumar A; Bradfield JP; Davies GE; Ma RCW; Mace A; Lewin AM; Felix JF; Viikari J; Nolte IM; Watkins WJ; Xu SJ; van Beijsterveldt T; Atalay M; Teo YY; Hakonarson H; Pulkkinen L; Widen EE; Smith GD; Wray NR; Palviainen T; Richmond RC; Mamun AA; Willemsen G; Hartman CA; Melen E; Oberfield SE; Medland SE; Li J; Rose RJ; Ahlqvist E; Eriksson JG; Ang W; Hebebrand J; Das S; McCarthy NS; Kerkhof M; Johansson S; Mannikko M; Duijts L; Bilbao JR; Tiemeier H; Bartels M; Pahkala K; Sebert S; Grarup N; Hirschhorn JN; Sunyer J; Lindi V; Pershagen G; Bonnelykke K; Reynolds RM; Vonk JM; Fedko IO; Borja JB; Charoen P; Eastwood PR; Dedoussis GV; Plomin R; Kulohoma B; Wilson JF; Pennell CE; Kotecha S; Lakka TA; Vrijkotte TGM; Vilor-Tejedor N; Rodriguez A; Adair LS; Oldehinkel AJ; Morgen CS; Salem R; Torrent M; Hinney A; Zeggini E; Tiemeier HN; Groop L; Nohr EA; Kahonen M; Kreiner-Moller E; Selzam S; Strachan DP; Taylor M; Hivert MF; Helgeland O; Karhunen V; Wichmann HE; Robertson NR; Sleiman PMA; Steegers EAP; Lindgren CM; Henderson J; Evans DM; Prokopenko I; Guxens M; Oken E; Murray JC; Gilsanz V; Straker L; Bisgaard H; Auvinen J; Lehtimaki T; Raitakari OT; Mbarek H; Hansen T; Estivill X; Jacobsson B; Curtin JA; Jugessur A; Thiering E; Whitehouse AJO; De Silva NM; Pedersen O; Skotte L; Perry JRB; Magi R; Elliott P; Martin NG; Nivard MG; Mohlke KL; Njolstad PR; Beckmann JS; Monnereau C; Jaddoe VWV; Zafarmand MH; Saw SM; van Duijn CM; Shepherd JA; Lahti J

The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as ...

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries

de Mutsert R; Kritchevsky SB; Heng CK; Vollenweider P; Howard BV; Wong TY; Samani NJ; Tai ES; Dorajoo R; Wu TC; He J; Jonas JB; Scott J; Guo XQ; Li CW; Rose LM; Bowden DW; Gasparini P; Alver M; Kahonen M; Rice K; van Duijn CM; Khor CC; Fau JD; Scott RA; Bartz TM; Sidney S; Fuentes LDL; Warren HR; Ehret G; Smith JA; Penninx BWJH; Wang YJ; Froguel P; Zonderman AB; Lehtimaki T; Hallmans G; Campbell A; Bin Wei W; Province MA; Kooperberg C; Palmas W; Leander K; Kubo M; Stancakova A; Zhu XF; Rankinen T; Boehnke M; Mohlke KL; Elliott P; Watkins H; Raffel LJ; Tham YC; Harris TB; Hagenaars SP; Poiasek O; Nelson CP; Wickremasinghe AR; Vojinovic D; Aschard H; Gieger C; Smith AV; Scott WR; Yu CZ; Winkler TW; O'Connell JR; Koh WP; Cheng CY; Munroe PB; Kutalik Z; Porteous DJ; Marten J; Laurie CC; Heikkinen S; Vitart V; Brumat M; Charumathi S; Ntalla I; Lewis CE; Afaq S; van Dam RM; Gao C; Varga TV; Broeckel U; Magnusson PKE; Feitosa MF; Boerwinkle E; Uitterlinden AG; Deng X; Loh M; Ware EB; Rao DC; Lakka TA; Snieder H; Louie T; Komulainen P; Lin S; Wang LH; Eppinga RN; Perls T; Brown M; Manning AK; Gudnason V; McKenzie CA; Mook-Kanamori DO; Yuan JM; Meitinger T; Hirata M; Yao J; Fisher V; Hartwig FP; Horta BL; Sims M; Burke GL; Momozawa Y; Waldenberger M; Morrison AC; Chambers JC; Li YZ; Eaton CB; Richard MA; Amin N; Freedman BI; Franks PW; Robino A; Langenberg C; Teo YY; Schmidt CO; Takeuchi F; Farrall M; Norris JM; Chakravarti A; Borecki I; Padmanabhan S; Chen X; Sim XL; Ridker PM; Franco OH; Rosendaal FR; Magi R; Liu YM; Launer LJ; van der Harst P; Bielak LF; Rueedi R; Roll K; Zheng W; Wagenknecht LE; Rauramaa R; Harris SE; Felix SB; Weir DR; Sofer T; Caulfield MJ; Kamatani Y; Nolte IM; van der Most PJ; Langefeld CD; Peyser PA; Tan NYQ; Franceschini N; Peters A; Said MA; Nalls MA; Kraja AT; Raitakari OT; Gao H; John U; Gigante B; Christensen K; Divers J; Kuusisto J; Fornage M; Katsuya T; Poulter N; Fox ER; Starr JM; Chen YDI; Milaneschi Y; Evangelou E; Rotter JI; Deary IJ; Luan J; Wen WQ; Liu JJ; Kato N; Kilpelainen TO; Evans MK; Kooner JS; Wojczynski MK; Wang YX; Milani L; Arking DE; Gandin I; Hsu FC; Rotimi CN; Schreiner PJ; Becker DM; Tang H; Tayo BO; Gauderman WJ; Sitlani CM; Schupf N; Weiss S; Gu DF; Laakso M; Stringham HM; Palmer ND; Williams C; Wareham NJ; Kuhnel B; Musani SK; Levy D; Cai QY; Goel A; Sotoodehnia N; Friedlander Y; Ghanbari M; Zhao W; Ding J; Liu JM; Canouil M; Psaty BM; Pereira AC; Lehne B; Brown MR; Shu XO; Riaz M; Connell JM; Chasman DI; Kelly TN; Cupples LA; Taylor KD; de Silva HJ; Chai JF; Duan Q; Krieger JE; Strauch K; Kasturiratne A; Turner ST; Lohman KK; Forouhi NG; He MI; Zhang WH; Horimoto ARVR; Amini M; Ikram MA; Tajuddin SM; Esko T; Gu CC; Jackson AU; Sever PS; Kardia SLR; Noordam R; Pedersen NL; Correa A; Metspalu A; Hagemeijer Y; Matoba N; Boissel M; Forrester T; Hayward C; Shi Y; Bentley AR; Oldehinkel AJ; Sung YJ; Study LC; Schwander K; Laguzzi F; Bouchard C; Aung T; Yanek LR; Zhao JH

Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP) regulation remains unknown. We hypothesized that a genome-wide association ...

Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels

Nolte IM; Mychaleckyj JC; Campbell H; Sabo A; Padmanabhan S; Demissie S; Viikari JS; Mbarek H; Kahonen M; Hofman A; Wilson JG; Sijbrands EJ; de Craen AJM; Nikus K; Franco OH; Morrison A; Ripatti S; Joshi PK; Tayo BO; Evangelou E; Jukema JW; de Mutsert R; Gudnason V; Lehne B; Deelen J; van Duijn CM; Kooner JS; White CC; Scott WR; Raitakari OT; Kooner AS; Lehtimaki T; Rivadeneira F; Chambers JC; Forrester T; Trompet S; Boomsma DI; Wilson JF; Gansevoort RT; Smith AV; Verweij N; Huffman JE; Borecki IB; Snieder H; Milaneschi Y; Rice KM; Zhang WH; Vitart V; Campbell A; Hocking LJ; Rudan I; Willemsen G; Elliott P; Salomaa V; Rotter JI; Rich SS; Brody JA; Segura-Lepe MP; van der Harst P; Tan ST; Boerwinkle E; Psaty BM; Cooper RS; Li-Gao RF; Cupples LA; van der Laan SW; Penninx BWJH; de Ruijter HM; Duan Q; Isaacs A; Harris T; Manichaikul A; McKenzie CA; Swertz M; Feitosa MF; van Leeuwen EM; Lyytikainen LP; Pasterkamp G; Oldehinkel AJ; Kolcic I; Marten J; Lange LA; de Geus EJ; Mook-Kanamori DO; van der Most PJ; Zemunik T; Navarro P; Surakka I; Bis JC; van Dijk KW; Uitterlinden AG; Hayward C; Polasek O; van Klinken JB; Dehghan A; Arking DE; Slagboom PE; Ford I

Background So far, more than 170 loci have been associated with circulating lipid levels through genome-wide association studies (GWAS). These associations are largely driven by common variants, their function is often not ...

Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

Yang Q; Felix JF; O'Connell J; Sveinbjornsson G; Schulz CA; Lieb W; Guilianini F; Ghasemi S; Wilson JF; Preuss MH; Palmer ND; Willer CJ; Hartman CA; Kramer BK; Foo VHX; Bansal N; Hung AM; Thorsteinsdottir U; Parsa A; Yu Z; Pirastu N; Gordon SD; Verweij N; Porteous DJ; Rice KM; Stefansson K; Magnusson PKE; Kuusisto J; Hveem K; Chai JF; Stringham HM; Waeber G; Campbell A; Phillips LS; Tin A; Heng CK; Franke A; Spedicati B; Gunther F; Huang W; Christensen K; Mishra PP; Langefeld CD; Morris AP; Okada Y; Burkhardt R; Ning B; Ciullo M; Schottker B; Schmidt R; Tao R; Pontali G; Ehret G; Friedlander Y; Nikus K; Girotto G; Tayo B; Giedraitis V; Stanzick KJ; Jakobsdottir J; Holm H; Gao H; Oldehinkel AJ; Vanderwerff BR; Orho-Melander M; Mychaleckyj JC; Kronenberg F; Loos RJF; Wallentin L; Citterio L; Lucae S; Rasheed H; Wang CL; Vaccargiu S; Bottinger EP; Salomaa V; Kahonen M; Scholz M; Waldenberger M; Bochud M; Freitag-Wolf S; Morgan A; Milaneschi Y; Tham YC; Kooner JS; O'Donoghue ML; Haller T; Stark KJ; Kovacs P; Daw EW; Korner A; Kerr SM; Salvi E; Sedaghat S; Melander O; Miliku K; Zonderman AB; Svensson PO; Polasek O; Kammerer CM; Rabelink TJ; Rudan I; Marz W; Rivadeneira F; Kastarinen M; Teumer A; Kramer H; Gaziano JM; de Vries APJ; Tan NYQ; Lim SC; Kirsten H; Feresin A; Noordam R; Thio CHL; Rossing P; Spracklen CN; Cook JP; Montgomery GW; Brumpton B; Gasparini P; Magi R; Patil SB; Lanzani C; Raitakari OT; Hamet P; Metspalu A; Smith AV; Waterworth DM; Manunta P; Reilly DF; Jung B; Martins J; Rizzi F; Nolte IM; Rowan BX; Vogelezang S; Graham SE; Heid IM; Pramstaller PP; Jaddoe VWV; Penninx BWJH; Gorski M; Coresh J; Feitosa MF; Koenig W; Boehnke M; Kuokkanen M; Banas B; Marten J; Rotter JI; Ikram MA; Lehtimaki T; Lyytikainen LP; Strauch K; Boutin TS; Gudbjartsson DF; Campbell H; Sim RZH; Wang YX; Tremblay J; Podgornaia AI; Catamo E; Lee JJM; Vitart V; Nalls MA; Xu J; Pistis G; Volker U; Peters A; Shaffer CM; Arnlov J; Delgado GE; Ryan KA; Mook-Kanamori DO; Rueedi R; Correa A; Divers J; van der Most PJ; Cocca M; Tai ES; Bergmann S; Martin NG; Hallan S; Launer LJ; Josyula NS; Lukas MA; Mononen N; Horn K; van der Harst P; Stumvoll M; Perola M; Chambers JC; Carroll RJ; Francescatto M; Raffield LM; Hayward C; Chee ML; Khor CC; Ahluwalia TS; Gansevoort RT; Snieder H; Brenner H; Biggs ML; Halbritter J; Hwang SJ; Padmanabhan S; Tonjes A; Chu AY; Cheng CY; Pattaro C; Thomas LF; Klaric L; Endlich K; Nutile T; Meitinger T; Taylor KD; De Grandi A; Laakso M; White HD; Bakker SJL; Kottgen A; Eckardt KU; Yerges-Armstrong LM; Sieber KB; Wei WB; Schmidt H; La Bianca M; Kanai M; Yasuda M; Ising M; Dehghan A; Kavousi M; Hutri-Kahonen N; Lindgren CM; Loeffler M; Hoppmann A; Dittrich K; Wuttke M; Jonas JB; Gieger C; Rosenkranz AR; Matsuda K; Guo F; Winkler TW; Mascalzoni D; Mahajan A; Kamatani Y; Dorajoo R; Gao X; Boerwinkle E; Joshi PK; Sabanayagam C; Evans MK; Psaty BM; Cusi D; Hofer E; Ruggiero D; Li Y; Sim XL; Boger CA; Toniolo D; Freedman BI; Piratsu M; Smith BH; Concas MP; Nadkarni GN; Robinson-Cohen C; Hicks AA; Felicita SC; Mohlke KL; Elliott P; Bergler T; Kleber ME; Gudnason V; Biino G; Liu JJ; Fuchsberger C; Esko T; Zhang WH; Kubo M; Asvold BO; Schupf N; Vollenweider P; Thiery J; Wong TY; van Dam RM; Ponte B; Ghanbari M; Wojczynski MK; Li HT; Whitfield JB; Ridker PM; Tzoulaki I; Teren A; Nauck M; Li M; Ho K; Lind L; Kiess W; de Borst MH; Akiyama M; Gogele M; Olafsson I; Chasman DI; Corre T; Province MA; Sulem P; Czamara D; Lange LA; de Mutsert R; Pendergrass SA; Devuyst O

<p>A large-scale GWAS provides insight on diabetes-dependent genetic effects on the glomerular filtration rate, a common metric to monitor kidney health in disease.Reduced glomerular filtration rate (GFR) can progress to ...

Genetic loci associated with heart rate variability and their effects on cardiac disease risk

Minassian A; Thayer JF; Boomsma D; Kumari M; Nolte IM; van der Harst P; Riese H; Christophersen IE; Teumer A; Sotoodehnia N; Maihofer AX; Avery CL; Kahonen M; Staessen JA; Rioux JD; Voss A; Kluttig A; Morris AP; Sundstrom J; Vaez A; Huikuri H; zu Schwabedissen HM; Lindgren CM; Zonderman AB; Huikari V; Wilhelmsen KC; Reiner AP; Albarwani S; North KE; Stilp AM; Bis JC; Nivard M; Wong A; Navis G; Stolarz-Skrzypek K; Ellinor PT; Zhang ZM; McKnight B; Whitsel EA; Albert C; Giedraitis V; Heckbert SR; Baker DG; Neijts M; Stein PK; Jansen R; Milaneschi Y; Hwang SJ; Liao DP; Perz S; Geyer MA; Li Y; van Roon AM; Rotter JI; Boucher G; Ormel J; Zafarmand MH; O'Connor DT; van der Most PJ; Verweij N; de Bakker PIW; Friberg P; Hutri-Kahonen N; Axelsson T; Cusi D; Amare AT; Soliman EZ; Asselbergs FW; Abdellaoui A; Britton AR; Salvi E; Gogarten SM; Penninx B; Hassan M; Mahajan A; Lind L; Nikus K; Smith NL; Lyytikainen LP; Kiviniemi AM; Greiser HK; Wong QN; Kooperberg C; van Dongen J; Lin HJ; Uitterlinden AG; Kivimaki M; Jarvelin MR; Kuznetsova T; Sofer T; Syvanen AC; Evans MK; Sinner MF; Nievergelt CM; O'Donnell CJ; Siscovick D; von der Heyde B; Psaty BM; Lubitz SA; Smit JH; Munoz ML; Hofman A; Floras JS; Franco OH; Stricker BH; Gademan MGJ; Bieringa RJ; de Geus EJC; Taylor KD; Hemerich D; Snieder H; Dietrich A; Barcella M; Kaab S; van Setten J; Brundel BJJM; Ingelsson E; Jaju D; Stewart JD; Strauch K; Kerr KF; Tiemeier H; Vrijkotte TGM; Willemsen G; Laurie CC; van der Laan SW; Hartman CA; Tragante V; Goyette P; Swenne CA; Hottenga JJ; Thornton TA; Risbrough VB; Oldehinkel AJ; Felix JF; Tardif JC; Kumar J; Mononen N; Zabaneh D; Muller-Nurasyid M; Ashar F; Limacher MC; Eskola M; Peters A; Lefrandt JD; Ehret GB; den Hoed M; Juonala M; Lehtimaki T; Hernesniemi J; Alonso A; Dierckx B; Auvinen J; Nalls MA; Raitakari OT; Kuh D; Kors JA; Krijthe BP; Bayoumi R; Waldenberger M; Tinker LE

Reduced cardiac vagal control reflected in low heart rate variability (HRV) is associated with greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide association studies for three HRV ...

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Harris TB; Tuomilehto J; Harder MN; James AL; Silbernagel G; Hutri-Kahonen N; Rudan I; Navarro P; Mahajan A; Kolcic I; Kutalik Z; Jackson AU; Balkau B; Marten J; Rankinen T; Stott DJ; Bandinelli S; Liu CT; Schlessinger D; Bien SA; Vestergaard H; Direk N; Holmen OL; van der Laan SW; Alfred T; Scholtens S; Marques-Vidal P; Olden M; Fisher VA; Hocking LJ; Kleber ME; Frayling TM; Eicher JD; Launer LJ; Lim U; Xue L; Lee NR; Lehtimaki T; Metspalu A; Rao DC; Jarvelin MR; Pervjakova N; Rasmussen-Torvik LJ; Chittani M; Strauch K; Lindgren CM; Qi L; Bergmann S; Volzke H; Heid IM; Strachan DP; Hottenga JJ; Hansen T; Haitjema S; Sorensen TIA; Kuh D; Bergman RN; Pasterkamp G; Sennblad B; McCarthy MI; Gong J; Nauck M; Bartz TM; Waeber G; Chasman DI; Strawbridge RJ; Dedoussis G; Justice AE; Wild S; Faul JD; Taylor KD; Chu AY; Hollensted M; Vedantam SL; Raitakari OT; Rauramaa R; Loh M; Eriksson J; Justesen JM; Savonen K; Cupples LA; Borecki IB; Fox CS; Hastie ND; Kivimaki M; Gudnason V; Heath AC; Narisu N; Madden PAF; Mohlke KL; Pisinger C; Wu Y; Eiriksdottir G; Barroso I; Perez J; Musk AW; Heard-Costa NL; Ludolph-Donislawski A; Lind L; Bonnycastle LL; Tyrrell J; Bragg J; Zhao W; Kvaloy K; Hassinen M; Lim E; Rice T; Hadley D; Froguel P; Winkler TW; Padmanabhan S; Gorski M; Chambers JC; Weir DR; Grabe HJ; Hirschhorn JN; Barata L; Curran JE; Campbell H; Peters U; Boehnke M; Peters A; Deng X; Langenberg C; Wilson JF; Loos RJF; de Borst GJ; Zubair N; Marchini J; Tayo BO; Afzal U; Hamsten A; Deloukas P; Hindorff L; Esko T; Chen YDI; Cusi D; Baldassarre D; Palmer LJ; Mellstrom D; Hayward C; de Faire U; Wright AF; Grallert H; Glorioso N; Scott RA; Linneberg A; Kinnunen L; Sarti C; Collins FS; Lorentzon M; Hernandez D; Spector TD; Forrester T; Schurmann C; Hung J; Luben R; Zhang WH; Grammer TB; Smith JA; Middelberg RPS; Smith BH; Oldehinkel AJ; Bielak LF; Johnson AD; Boomsma DI; Jhun MA; Vink JM; Stringham HM; Ingelsson E; Marz W; Zillikens MC; Bakker SJL; North KE; Kramer BK; Gigante B; Jansson JO; Huang J; Kooner JS; Graff M; Bonnefond A; Kardia SLR; Jorgensen ME; Kahonen M; Vonk JM; Polasek O; Ong KK; Corre T; Vollenweider P; Morris AP; Perusse L; Gertow K; Hveem K; Tiemeier H; Franks PW; Slagboom PE; Zimmermann ME; Martin NG; Sanna S; Biffar R; Bottinger E; Ohlsson C; McKnight B; Czajkowski J; Hunter DJ; Stancakova A; Horikoshi M; van der Most PJ; Verweij N; Thuillier D; Komulainen P; Ridker PM; Boerwinkle E; Peyser PA; Waldenberger M; Ferrucci L; Van Vliet-Ostaptchouk JV; Chines PS; Van der Harst P; Staessen JA; Psaty BM; Delgado GE; Rose LM; Afaq S; Eriksson AL; Hartman CA; Boger CA; Beilby J; Grarup N; Adair LS; Young K; Mannikko R; Haiman CA; van Duijn CM; Sarzynski MA; Mueller-Nurasyid M; Ford I; Manichaikul A; Huang T; Rawal R; Amin N; Westendorp RGJ; Nolte IM; Wolffenbuttel BHR; Koistinen HA; Swertz MA; Wu J; Laakso M; Smith AV; Montgomery GW; Fischer K; Willemsen G; Wong A; Le Marchand L; Leander K; Blangero J; Whitfield JB; Ahmad S; Buyske S; Menni C; Cadby G; Gordon-Larsen P; Lupoli S; Vandenput L; Kanoni S; Kumari M; Braga D; Feitosa MF; den Ruijter HM; Jukema W; Sung YJ; Bouchard C; Hallmans G; Thorand B; Abecasis GR; Karlsson M; de Craen AJM; Vitart V; Porteous DJ; Siemelink MA; Qi QB; Lobbens S; Uitterlinden AG; Kolovou G; Tanaka T; McKenzie CA; Lubke G; Kooperberg C; Snieder H; Zhao JH; Ahluwalia TS; Homuth G; Luan J; Cucca F; Renstrom F; Lyytikainen LP; Huffman JE; Teumer A; Swift AJ; Yengo L; Mangino M; Wareham NJ; Sattar N; Lakka TA; Kuusisto J; Buckley BM; Ngwa JS; Trompet S; Kilpelainen TO; Tremoli E; de Geus EJC; Pedersen O; Vohl MC; Juonala M; Cooper RS; Coggeshall S; Bruinenberg M

Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, ...

CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits

Cusi D; Franke L; Noukas M; Raitakari OT; Perola M; Kutalik Z; Sinisalo J; Reymond A; Koponen P; Loos RJF; Sapkota Y; Yaghootkar H; Oldehinkel AJ; Geller F; Lokki ML; Metspalu A; Chambers JC; Porcu E; Nolte IM; Wain LV; Jacquemont S; Strachan DP; Sparso T; Ang WQ; Kahonen M; Feitosa MF; Perls TT; Wood AR; Mannik K; Lundqvist A; Rissanen H; Salvi E; Snieder H; Palotie A; Bottinger EP; Venturini C; Lehtimaki T; Beaumont RN; Koskinen S; Wray NR; Hirschhorn J; Kriebel J; Mannisto S; Heid IM; Werge T; Shrine N; Hansen TF; Meitinger T; Beckmann JS; Lettre G; Schick U; Peters A; Deloukas P; Ruth KS; Newman AB; Wojczynski MK; Boers H; Lenzini P; Frayling TM; Nieminen M; Afaq S; Liu XP; Martin NG; Medland SE; Tyrrell J; Kristiansson K; Melbye M; Mattsson H; Christensen K; Porteous D; Feenstra B; Kooner JS; Muller-Nurasyid M; Magi R; Deelen P; Freathy RM; van der Most PJ; Salomaa V; Hayward C; Viikari JS; Schupf N; Nyholt DR; Winkler TW; Jones SE; Zhang WH; Spector TD; Havulinna AS; Lahti J; Bochud M; Eriksson JG; Rueger S; Province MA; Tobin MD; Weedon MN; Rivadeneira F; Vartiainen E; Tuke MA; Mangino M; Swertz MA; McDaid AF; Montgomery GW; Murray A; Rosengren A; Pennell C; Borodulin K; Mace A

There are few examples of robust associations between rare copy number variants (CNVs) and complex continuous human traits. Here we present a large-scale CNV association meta-analysis on anthropometric traits in up to ...

PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity

Polasek O; Arnar DO; Tarasov KV; Boerwinkle E; Samani NJ; Pramstaller PP; Lin HJ; Butler AM; Avery CL; Ulivi S; Trompet S; Parsa A; de Bakker PIW; Macfarlane PW; Verweij N; Ritchie MD; Lin HH; Hayward C; Krijthe BP; Volzke H; Lyytikainen LP; Spector TD; Heckbert SR; Ehret GB; Barnard J; Soliman EZ; Gharib SA; Strauch K; Gasparini P; Sinagra G; Hicks AA; Munzel T; Felix SB; Bis J; Eijgelsheim M; Asselbergs FW; Roden DM; Kerr KF; Rudan I; Psaty BM; Benjamin EJ; Gudbjartsson DF; Snieder H; Liu YM; Wilson JF; Thorsteinsdottir U; Waldenberger M; Stricker BH; Teumer A; Schnabel RB; Muller-Nurasyid M; Buckley BM; van der Harst P; Steri M; Jukema JW; Alonso A; Loos RJF; Lehtimaki T; Smith AV; Campbell H; Pfeufer A; Nolte IM; Westra HJ; Jamshidi Y; Padmanabhan S; Yin XY; Mitchell BD; Uitterlinden AG; Arking DE; Sinner MF; Van Wagoner DR; Ferrucci L; Lubitz SA; Bradford Y; Aldana CTS; Launer LJ; van Setten J; Magnani JW; Isaacs A; Crawford D; Cucca F; Volker U; Ilaria G; Dorr M; Raitakari OT; Peters A; Gudnason V; Lakatta EG; Evans DS; Swenson BR; Zeller T; Stott DJ; Papanicolaou GJ; Kors JA; Schlessinger D; Del Greco FM; Munroe PB; Leach IM; Kaab S; Gibson Q; Bandinelli S; Blankenberg S; Kahonen M; Robino A; Brody JA; Dominiczak AF; den Hoed M; Wild PS; Sotoodehnia N; Holm H; van Duijn CM; Stefansson K; Harris TB; Bader JS; Iorio A; Tanaka T; Franke L; Rotter JI; Meitinger T; Denny JC; Smith JD; Muller C; Chung MK; Franco OH; Kolcic I; Ellinor PT

Electrocardiographic PR interval measures atrio-ventricular depolarization and conduction, and abnormal PR interval is a risk factor for atrial fibrillation and heart block. Our genomewide association study of over 92,000 ...

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Zhang WH; Wilsgaard T; Campbell H; Dimitriou M; Strawbridge RJ; North KE; Holmen O; Simino J; O'Connell JR; Deloukas P; Salomaa V; Richards M; Wild SH; Pankow JS; Oostra BA; Lorentzon M; Lehtimaki T; Benaglio P; Vohl MC; Kumari M; Vitart V; Rueger S; Eiriksdottir G; Lobbens S; Jordan JM; McCarthy MI; Hillege H; Nolte IM; Walker M; Vermeulen SH; Baldassarre D; Boehm BO; Waeber G; Alves AC; Chakravarti A; Uitterlinden AG; Huikuri HV; Rivadeneira F; Bruinenberg M; Walker RW; Magi R; Friedrich N; van Schoor NM; Kooner JS; Farrall M; Gyllensten U; Njolstad I; Bellis C; Stancakova A; Feitosa MF; Czajkowski J; Menni C; Pramstaller PP; Cusi D; Tsafantakis E; Pascoe L; Lind L; Eriksson J; Bakker SJL; Staessen JA; Bonnefond A; Merger S; Psaty BM; Jukema JW; Pilia MG; Vlachopoulou E; Cucca F; Kathiresan S; Thorsteinsdottir U; Hui J; Chines PS; de Craen AJM; Mantyselka P; Krarup NT; Boyd HA; Koskinen S; Froguel P; Loos RJF; Beilby J; Buchman AS; Gansevoort RT; Smit JH; van der Harst P; Kutalik Z; Rauramaa R; Jorgensen T; Scholtens S; Mahajan A; Gu YM; Boomsma DI; Pervjakova N; Bluher M; Leach IM; Cadby G; Waldenberger M; Musk AW; Renstrom F; Sarzynski MA; Fox CS; Neinast MD; Rotter JI; Hassinen M; van der Velde N; Tuomilehto J; Launer LJ; Liu YP; van Setten J; Tonjes A; Sorensen TIA; Palotie A; Langenberg C; Lindgren CM; Collins FS; Sung YJ; Kuh D; Lettre G; Heliovaara M; Stirrups K; Grarup N; Juonala M; Lahti J; Ferrucci L; Rice KM; Kaplan RC; Moll FL; Laakso M; Husemoen LL; Swift AJ; Tyrer JP; Clegg DJ; Ridker PM; Monda KL; Farmaki AE; Thorand B; Franks PW; Smith AV; Willenborg C; Rao DC; Bergman RN; Sennblad B; Liu YF; Maerz W; Justice AE; Illig T; Dedoussis G; Grassler J; Viikari JS; Koenig W; Bennett DA; Graff M; Jacobs KB; Rayner NW; Wennauer R; Willemsen G; Pedersen NL; Pers TH; Gudnason V; Zeggini E; Kaakinen M; Albrecht E; de Geus EJC; Hirschhorn JN; Rizzi F; Tachmazidou I; Eury E; Hu F; Schwarz PEH; Jalilzadeh S; Gottesman O; Grammer TB; Waite LL; Duan J; Raitakari OT; Stefansson K; Hayward C; Hartman CA; Schunkert H; Kolcic I; Kiemeney LALM; Mitchell BD; Teumer A; Gustafsson S; Ryan KA; Hall P; Goel A; Yu L; Tanaka T; Heard-Costa NL; Beckmann JS; Luben R; Franke L; Leander K; Volker U; Sanders AR; Jula A; Sattar N; Fischer K; Mohlke KL; Hovingh KG; Delgado G; Bergmann S; Spector TD; Lu YC; Linneberg A; Kittner SJ; Bouchard C; Broer L; Kilpelainen TO; Barcella M; Chen YDI; Bonnycastle LL; Vandenput L; van der Laan SW; Syvanen AC; Metspalu A; Koistinen HA; Ferreira T; Sinisalo J; McArdle WL; Boerwinkle E; Bonnet F; Knekt PB; Wong A; Jansen R; Lyssenko V; Seufferlein T; Lannfelt L; Muller-Nurasyid M; Hysi PG; Tan ST; Lokki ML; Heath AC; Morris AP; den Ruijter HM; Rioux JD; Sebert S; Zhao JH; Tremblay A; Hicks AA; Yerges-Armstrong LM; Bottinger EP; Lindstrom J; Vonk JM; Sengupta S; Montasser ME; de Groot LCPGM; Gorski M; Kahonen M; Gejman PV; Grallert H; Pouta A; Blangero J; Verweij N; De Jager PL; Absher D; Qi L; Ham AC; Pedersen O; Demirkan A; Groop LC; Ford I; Frau F; Thorleifsson G; Kinnunen L; Khaw KT; Strachan DP; Banasik K; Teslovich TM; Rudan I; Stefania B; Lotay V; Cole J; Bis JC; Barlassina C; Hutri-Kahonen N; Kleber ME; Sparso TH; Oldehinkel AJ; Perola M; Ahluwalia TS; Hattersley AT; Madden PAF; Hamsten A; Quertermous T; Wilson JF; Hengstenberg C; Ong KK; Berndt SI; Hastie N; Westra HJ; Salo P; Chambers JC; Tremoli E; Johansson A; Stringham HM; Trompet S; Boucher G; Kajantie E; Ingelsson E; Barata L; Chu S; Scharnagl H; Hottenga JJ; Ohlsson C; Glorioso N; Mannisto S; Gordon-Larsen P; Ahmad S; Karaleftheri M; Levinson DF; Hunter DJ; Fall T; Montgomery GW; de Faire U; Borecki IB; Kruger J; Stolk RP; Jaquish CE; de Bakker PIW; Pasterkamp G; Lagou V; Lanzani C; Karjalainen J; Silveira A; Henders AK; McKnight B; Saltevo J; Forouhi NG; Rice TK; Winkler TW; Hingorani A; Ehret GB; Milani L; Evans DA; Esko T; Boehnke M; Pichler I; Peters A; Mangino M; Eklund N; Bragg-Gresham JL; Lehne B; Cheng YC; Vollenweider P; Hveem K; Erdmann J; Muller G; Harris TB; Galesloot TE; Gieger C; Schlessinger D; Kratzer W; Kanoni S; Hernandez D; Gigante B; Shi JX; van Duijn CM; Hansen T; Magnusson PK; Abecasis GR; Asselbergs FW; Panoutsopoulou K; Wang SR; Assimes TL; Prokopenko I; Eriksson JG; Scott WR; Slagboom PE; Shuldiner AR; Cupples LA; Polasek O; Wallaschofski H; Boger CA; Heid IM; Rose LM; Claudi-Boehm S; Chasman DI; Rivolta C; Paternoster L; Wang ZM; van Dijk SC; Scott RA; Lakka TA; Mihailov E; Chiang CWK; Penninx BW; Enroth S; James AL; Kyriakou T; Volzke H; Medina-Gomez C; Dueker N; Feenstra B; Yengo L; Kovacs P; Verbeek ALM; Nelis M; Ribel-Madsen R; van Vliet-Ostaptchouk JV; Rankinen T; Steinthorsdottir V; Huffman JE; Kuusisto J; Swertz MA; Go AS; Melbye M; Geller F; Zillikens MC; Narisu N; Watkins H; Kivimaki M; Snieder H; Sanna S; Rheinberger M; Southam L; Haitjema S; Hofman A; Wright AF; Murray JC; Jackson AU; Bornstein SR; Perusse L; Stumvoll M; Widen E; Wareham NJ; White CC; Luan J; Uusitupa M; Gronberg H; Lo KS; Palmer LJ; Tardif JC; Martin NG; Barroso I; Andersson EA; Chanock SJ; Yang J; Nieminen MS; van der Most PJ

<p> Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body ...