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Mitochondrial genome-wide analysis of nuclear DNA methylation quantitative trait loci
<p>Mitochondria have a complex communication network with the surrounding cell and can alter nuclear DNA methylation (DNAm). Variation in the mitochondrial DNA (mtDNA) has also been linked to differential DNAm. Genome-wide ...
Long-term tracking and population characteristics of lipoprotein (a) in the Cardiovascular Risk in Young Finns Study
<p>Background and aims</p><p>Lipoprotein (a) (Lp(a)) is a causal risk factor for cardiovascular diseases and its levels are under strict genetic control. Therefore, it is hypothesized that the concentration of Lp(a) remains ...
Magical thinking in individuals with high polygenic risk for schizophrenia but no non-affective psychoses-a general population study
A strong genetic background for psychoses is well-established. Most individuals with a high genetic risk for schizophrenia, however, do not develop the disorder. We investigated whether individuals, who have a high genetic ...
Adulthood blood levels of hsa-miR-29b-3p associate with preterm birth and adult metabolic and cognitive health
Preterm birth (PTB) is associated with increased risk of type 2 diabetes and neurocognitive impairment later in life. We analyzed for the first time the associations of PTB with blood miRNA levels in adulthood. We also ...
Uncovering the complex genetics of human temperament
<p>Experimental studies of learning suggest that human temperament may
depend on the molecular mechanisms for associative conditioning, which
are highly conserved in animals. The main genetic pathways for
associative ...
Examining the effect of mitochondrial DNA variants on blood pressure in two Finnish cohorts
<p>High blood pressure (BP) is a major risk factor for many noncommunicable diseases. The effect of mitochondrial DNA single-nucleotide polymorphisms (mtSNPs) on BP is less known than that of nuclear SNPs. We investigated ...
Three genetic-environmental networks for human personality
Phylogenetic, developmental, and brain-imaging studies suggest that human personality is the integrated expression of three major systems of learning and memory that regulate (1) associative conditioning, (2) intentionality, ...