Selaus oppiaineen mukaan kokoelmassa 1. Kirjat ja opinnäytteetBioinformatics
Aineistot 1-20 / 44
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ADMET and adverse effects predictive modeling based on FDA-approved drugs Data
(Turun yliopisto, 31.01.2017)Absorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) properties and adverse effects determine the success of each drug. These factors play an important role in the late-stage failure of drug candidates and ... -
Adopting the Vaadin Java framework to rebuild VTT’s Web Interfaces and Database Applications
(Turun yliopisto, 14.12.2015)With the growth in new technologies, using online tools have become an everyday lifestyle. It has a greater impact on researchers as the data obtained from various experiments needs to be analyzed and knowledge of programming ... -
Analysis of Alpha CA Genes in Early Vertebrates and ; High-Invertebrates
(Turun yliopisto, 08.06.2016)Carbonic anhydrases are enzymes that are ubiquitously found in all organisms that are engaged in catalyzing the hydration of carbon dioxide to form bicarbonate and proton and vice versa. They are crucial in the process of ... -
Analysis of differential alternative splicing at the gene isoform and genomic levels using Cufflinks, Miso, and rMats – an example of ANO7 in prostate cancer
(05.06.2020)The diagnosis and treatment of prostate cancer (PCa) are the most extensively researched fields in Urology. Studying gene expression profiling in PCa as well as in other types of cancer necessitates the investigation of ...suljettu -
Analysis of the Phosphoproteome of Jnk1-/- vs Wild Type Mouse Brain Provides Novel Insight on JNK1's Interaction Profile and Its Connection to Various Mental Disorders
(Turun yliopisto, 05.03.2018)c-Jun N-terminal kinases (JNKs) are multifunctional kinases that are involved in various diseases. The JNK pathway plays a major role in cell death in response to a variety of stimuli; it hence plays a part in diseases ... -
Annotation of Gyrodactylus salaris transcriptome
(Turun yliopisto, 15.06.2016)Relationship between organisms within an ecosystem is one of the main focuses in the study of ecology and evolution. For instance, host-parasite interactions have long been under close interest of ecology, evolutionary ... -
Assessing Data Quality in Disease-Specific Patient Information Systems
(19.05.2020)BCB Medical provides disease-specific patient information systems for collection of patient data, and information services for clinical research as well as for public and private hospitals. There are over 100 disease-specific ...suljettu -
Comparison of de novo metagenomic assembly tools
(24.05.2019)The field of metagenomics involves studying the composition and function of microbial communities via isolated DNA from a variety of environments like soil, water and the human gut. Since the current generation sequencing ...suljettu -
Comparison of five popular normalization methods using a spike-in proteomics data set
(Turun yliopisto, 18.08.2016)Mass spectrometry (MS)-based proteomics has seen significant technical advances during the past two decades and mass spectrometry has become a central tool in many biosciences. Despite the popularity of MS-based methods, ... -
Comparison of peptide peak intensity methods for label free relative protein quantification
(Turun yliopisto, 21.02.2018)During the recent years, Liquid chromatography-mass spectrometry (LC-MS) has gained enormous attention to identify and quantify peptides in biological samples. The Current challenge is to quantify the level of proteins as ... -
Computational inference of functional relationships from multiple genomes : Drosophila carbonic anhydrases.
(Turun yliopisto, 24.09.2018)Carbonic anhydrases (CAHs) are metalloenzymes which catalyze the reversible chemical reaction between carbon dioxide and water to bicarbonate and a proton, which is crucial in pH homeostasis. There are several CAH families ... -
Computational methods and tools for protein phosphorylation analysis
TUCS Dissertations : 237 (Turun yliopisto, 05.04.2019)Signaling pathways represent a central regulatory mechanism of biological systems where a key event in their correct functioning is the reversible phosphorylation of proteins. Protein phosphorylation affects at least ... -
De novo transcriptome assembly and annotation of the isopod Idotea balthica
(Turun yliopisto, 24.05.2016)The Baltic Sea is a unique environment that contains unique genetic populations. In order to study these populations on a genetic level basic molecular research is needed. The aim of this thesis was to provide a basic ... -
Development of pipeline for gut microbiome data analysis using R programming
(31.01.2022)Microorganisms are present everywhere in the environment. They are present on and inside of all higher organisms and they can be harmful as well as useful for the host. Microorganisms play an important role in the evolution ...avoin -
Development of workflow for picornavirus genome sequence analysis
(03.07.2020)Picornaviruses are small, non-enveloped, icosahedral, positive stranded RNA viruses and among the most common human pathogens. Some of the clinically important genera for humans are Enterovirus, Hepatovirus, Parechovirus ...avoin -
Evaluation of variant calling tools for detecting structural variants using real and simulated genomic datasets
(12.09.2018)Structural variants are generally defined as DNA variations larger than 50bp. They have been recognized as the largest source of inter-individual genetic variation and shown to play an important role in human life. Genomic ...suljettu -
Exon analysis with CAbase : a novel Carbonic Anhydrases database tool.
(21.12.2020)The Carbonic Anhydrases are a superfamily of proteins, a type of metalloenzyme that are found ubiquitously throughout the most diverse clades in the tree of life. Since first identified as a catalyst for the reversible ...avoin -
Genomic comparisons of carbonic anhydrase V genes in vertebrates
(Turun yliopisto, 11.07.2018)Carbonic anhydrases are involved in many processes of life, have been discovered in every living organism, and are widely distributed in tissues. Carbonic anhydrases are involved in different biochemical processes, such ... -
High throughput prediction of inter-protein coevolution
(14.11.2018)Inter-protein co-evolution analysis can reveal in/direct functional or physical protein interactions. Inter-protein co-evolutionary analysis compares the correlation of evolutionary changes between residues on aligned ...avoin -
Human Ezrin: Prediction of the 3D structure and interactions with mTOR
(Turun yliopisto, 15.06.2016)The protein Ezrin, is a member of the ERM family (Ezrin, Radixin and Moesin) that links the F-actin to the plasma membrane. The protein is made of three domains namely the FERM domain, a central α-helical domain and the ...