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Thyroid hormones (THs) are essential for normal growth and development. Insufficient production of THs at birth leads to congenital hypothyroidism (CH) affecting approximately 1:3000 newborns worldwide. The etiology of CH ...

The GABAA receptor is a ligand-gated ion channel that conveys inhibitory signals in neurons. It is a pentameric receptor assembled from combinations of 19 subunits, however, most receptors are composed of α-, β- and ...

Rintasyöpä on naisten yleisin syöpätyyppi ja Suomessa siihen sairastui vuonna 2015 yli 5000 naista. Suuri osa rintasyöpään sairastuneista saa leikkauksen jälkeen riskiarvion mukaan liitännäishoitona lääke- tai/ ja sädehoitoa. ...

Triple-negative breast cancer (TNBC) is a cancer sub-type with poor prognosis and it lacks targeted therapies. The c-Abl is a non-receptor tyrosine kinase as well as a proto-oncoprotein. It has a role in DNA damage cascade ...

Adiponectin (AdipoQ) is a major adipokine with insulin-sensitizing and anti-inflammatory effects. AdipoQ expression is downregulated in obesity, insulin resistance and type 2 diabetes. In this study, we investigated the ...

B cells are responsible for the humoral responses of the adaptive immune system. B cells also act as antigen presenting cells: they internalize protein antigens and process them into peptides for presentation on Major ...

Acute myeloid leukemia (AML) is a hematological cancer where myeloid stem cells are transformed into malignant cells, filling and replacing the cells in a healthy bone marrow. Cytarabine is a nucleoside analog used in ...

Aim of this study was to evaluate silica’s ability to promote inflammation. Amorphous silica could be used in sustained drug delivery systems, but it needs to be proven to be safe. Neutrophils ability to phagocytose ...

Parkinson’s disease (PD) is most common movement disorder of the central nervous system in the world. Prevalence of PD increases by age, being 3000 per 100 000 in over 70 year olds. Pharmacological treatments of PD are ...