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α2B-ADRENOCEPTORS IN THE REGULATION OF VASCULAR SMOOTH MUSCLE CELL CONTRACTION AND PROLIFERATION
(Turun yliopisto, 2017-09-22)
α2-Adrenoceptors (α2-ARs) belong to the large superfamily of G protein-coupled receptors
(GPCRs). They mediate important actions of the endogenous catecholamines adrenaline and
noradrenaline. All three α2-AR subtypes ...
Intratumoral androgen biosynthesis in prostate cancer: Evidence from preclinical models and clinical specimens
(Turun yliopisto, 2017-09-22)
Androgens regulate the growth and development of normal prostate and prostate cancer. Blocking the production and effects of androgens, either by castration or medication, has been the most efficient strategy for treating ...
A Farewell to Flat Biology. Three-dimensional Cell Culture Models in Cancer Drug Target Identification and Validation
(Annales Universitatis Turkuensis D 1028Turun yliopisto, 2012-09-14)
Cells of epithelial origin, e.g. from breast and prostate cancers, effectively differentiate into complex multicellular structures when cultured in three-dimensions (3D) instead of conventional two-dimensional (2D) adherent ...