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SUMOylation regulates nuclear accumulation and signaling activity of the ErbB4 receptor tyrosine kinase
(2019-03-08)
Erb-B2 receptor tyrosine kinase 4 (ErbB4) is a kinase that can signal via a proteolytically released intracellular domain (ICD) in addition to classical receptor tyrosine kinase–activated signaling cascades. Previously, ...
Osteoblastien erilaistumisen ja toiminnan transkriptionaalinen säätely
(Turun yliopisto, 2017-02-15)
PARP Inhibitors in Prostate Cancer – The Preclinical Rationale and Current Clinical Development
(2020-03-17)
Prostate cancer is the second most commonly diagnosed cancer type in men in the Western world. The majority of prostate cancer patients have a good prognosis, while some prostate cancers advance locally or metastasize. ...
ErbB4 tyrosine kinase inhibition impairs neuromuscular development in zebrafish embryos
(2020-01-23)
Reseptorityrosiinikinaasit (RTK) ovat kasvutekijäreseptoreita, jotka välittävät solujen kasvua, erilaistumista ja selviytymistä. RTK:en yli-ilmentyminen ja mutaatiot ovatkin tavallista erilaisissa sairauksissa, kuten ...
Osteoblastien erilaistumisen ja toiminnan transkriptionaalinen säätely
(Turun yliopisto, 2017-02-17)
Screening fungal lectin activities from mushroom extracts with special reference on the Inocybe lectin and its specificity
(2019-05-24)
The aim of this study was to screen mushroom extracts in search of lectin activities. This was carried out by homogenizing total amount of 129 mushroom samples and measuring their hemagglutination and hemolysis when mixed ...
Farmakogenetiikka saapui klinikkaan - miten hyödyntää genomitietoa potilastyössä
(Turun yliopisto, 2016-03-02)
Novel approaches for ErbB receptor tyrosine kinase inhibition
(2020-12-14)
ErbB receptor tyrosine kinases are cell-surface proteins that regulate cell proliferation, differentiation, and survival. The four ErbB family members – EGFR, ErbB2, ErbB3 and ErbB4 – function abnormally in certain types ...
Tuorekudosnäytteiden NGS-tutkimuksen validointi BRCA1/2-geenien kliiniseen diagnostiikkaan
(2021-02-24)
Tutkimuksen aiheena on rinta- ja munasarjasyöpään liittyvien BRCA1/2-geenien testaus. Tarkoituksena oli uuden geenitestimenetelmän validointi kliinistä diagnostiikkaa varten. Aiemmin BRCA1/2-geenien mutaatioita on tutkittu ...
The guanine nucleotide exchange factor VAV3 participates in ERBB4-mediated cancer cell migration
(2020-12-14)
ERBB4 is a cell surface receptor that belongs to the ERBB family of receptor tyrosine kinases. Binding of a ligand to the extracellular domain leads to the activation of the intracellular kinase domain and autophosphorylation ...