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Cellular regulation of the norepinephrine transporter
(Turun yliopisto, 2018-02-23)
The norepinephrine (NE) transporter (NET) mediates high-affinity uptake of the neurotransmitter NE in central and peripheral noradrenergic neurons. NET has a critical function in controlling the synaptic levels of NE and ...
The role of neuropeptide Y in the pathogenesis of the metabolic syndrome : A study of liver metabolism in transgenic mice overexpressing neuropeptide Y in noradrenergic neurons
(Turun yliopisto, 2018-11-16)
The metabolic syndrome (MetS) is a set of symptoms related to obesity, predisposing patients to cardiovascular diseases, and recently hepatosteatosis has been shown to play a major role in its pathogenesis. Neuropeptide Y ...
Calcium signaling and neuropeptide Y in experimental models of heart failure
(Turun yliopisto, 2020-11-13)
Despite advances in medical therapy and interventional procedures, heart failure carries a dismal prognosis. Calcium has a central role in controlling the contractility of the heart, and the sarcoplasmic reticulum Ca2+ ...
Fadolmidine – an alpha2-adrenoceptor agonist for spinal analgesia : analgesic effect and safety in preclinical in vivo models
(Turun yliopisto, 2021-01-29)
Pharmacological activation of α2-adrenoceptors is known to induce a characteristic pattern of pharmacodynamic responses including sedation, bradycardia, initial hypertension followed by hypotension, hypothermia and analgesia. ...
Cavity-based negative images in molecular docking
(Turun yliopisto, 2021-10-01)
In drug development, computer-based methods are constantly evolving as a result of increasing computing power and cumulative costs of generating new pharmaceuticals. With virtual screening (VS), it is possible to screen ...
Patient recruitment, feasibility evaluations and use of electronic health records in clinical trials - A Nordic approach
(Turun yliopisto, 2021-11-19)
Clinical trials constitute an important cornerstone for the development of new drugs. Patient recruitment is one of the main challenges in clinical trials. Pharmaceutical companies apply feasibility evaluations to identify ...