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Effect of melanocortin-1 receptor in the regulation of beta3-adrenoceptor agonist-induced BAT thermogenesis
(Turun yliopisto, 2019-03-01)
Adipose tissue is comprised of brown and white adipose tissues. In particular, brown adipose tissues (BAT) or brown fat contain rich amount of beta3-adrenoceptors (β3AR) and they are regulated by sympathetic nervous system ...
Role of PIM kinase-mediated regulation of Notch3 receptor protein in breast cancer
(Turun yliopisto, 2018-07-09)
Characterization of the novel solute carrier 26A7 gene and its impact on thyroid cell function
(2019-10-10)
Thyroid hormones (THs) are essential for normal growth and development. Insufficient production of THs at birth leads to congenital hypothyroidism (CH) affecting approximately 1:3000 newborns worldwide. The etiology of CH ...
Validation of novel prognostic biomarkers for treatment response in ovarian cancer and FFPE-sample applicability
(Turun yliopisto, 2018-01-02)
Munasarjasyöpä on Suomessa toiseksi yleisin gynekologinen syöpä ja aiheuttaa viidenneksi eniten naisten syöpäkuolemia. Kliinisesti merkittävin alatyyppi on high grade seroosit munasarjasyövät (HGSOvC). Tyypillisesti HGSOvC ...
Imaging and target screening for novel avenues for psychiatric disorder treatments
(2020-02-18)
The JNK pathway is linked to both schizophrenia and depression but its impact is still being investigated. Zebrafish larvae at 7 days post-fertilization, were monitored for evoked motility changes after exposure to a variety ...
The role of the GABAA receptor δ subunit domains on agonist binding kinetics
(2019-11-27)
The GABAA receptor is a ligand-gated ion channel that conveys inhibitory signals in neurons. It is a pentameric receptor assembled from combinations of 19 subunits, however, most receptors are composed of α-, β- and ...
Mechanistic study of JNK inhibition in the context of depression
(2019-10-10)
Study 1:
Anxiety and depression disorders are the largest contributor for global disability and affects 4% of the world population. The patient remission rate is only 30-40% with single anti-depressant treatment, leaving ...
Farmakokineettisten geenimuunnosten vaikutus liitännäislääkehoitona annetun dosetakselin aiheuttaman neutropenian riskiin ja hoidon tehoon suomalaisilla rintasyöpään sairastuneilla naisilla
(2018-10-04)
Rintasyöpä on naisten yleisin syöpätyyppi ja Suomessa siihen sairastui vuonna 2015 yli 5000 naista. Suuri osa rintasyöpään sairastuneista saa leikkauksen jälkeen riskiarvion mukaan liitännäishoitona lääke- tai/ ja sädehoitoa. ...
The Role of c-Abl Kinase in Cancer Cells Sensitivity to Mitoxantrone
(Turun yliopisto, 2018-07-09)
Triple-negative breast cancer (TNBC) is a cancer sub-type with poor prognosis and it lacks targeted therapies. The c-Abl is a non-receptor tyrosine kinase as well as a proto-oncoprotein. It has a role in DNA damage cascade ...