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Covalent conjugates of therapeutic oligonucleotides for in vivo targeting
(Turun yliopistoAnnales Universitatis Turkuensis A I 546, 2016-09-30)
Over last few years, the development of oligonucleotide based therapeutics (antisense, siRNA, antagomirs) have received much interest as a novel class of drugs for the treatment of many diseases. Cell/organ ...
Tautomerism and Fragmentation of Biologically Active Hetero Atom (O, N)-Containing Acyclic and Cyclic Compounds Under Electron Ionization
(Turun yliopistoAnnales Universitatis Turkuensis A I 392, 2009-04-17)
In this thesis a total of 86 compounds containing the hetero atoms oxygen and nitrogen were studied under electron ionization mass spectrometry (EIMS). These compounds are biologically active and were synthesized by various ...
Artificial Ribonucleases: Oligonucleotides Conjugated with Metal Ion Chelates of Azacrowns
(Turun yliopistoAnnales Universitatis Turkuensis A I 494, 2014-11-07)
Ribonucleic acid (RNA) has many biological roles in cells: it takes part in coding, decoding, regulating and expressing of the genes as well as has the capacity to work as a catalyst in numerous biological reactions. These ...
Fluorine and 18F-Fluorine in Radiopharmaceutical Preparation
(Turun yliopistoAnnales Universitatis Turkuensis A I 458, 2013-04-05)
Reactions of Chlorambucil and its main metabolite, Phenylacetic Acid Mustard, with 2’-deoxyribonucleosides and Calf Thymus DNA
(Turun yliopistoAnnales Universitatis Turkuensis AI 401, 2009-10-23)
Chlorambucil is an anticancer agent used in the treatment of a variety of cancers, especially in chronic lymphocytic leukemia, and autoimmune diseases. Nevertheless, chlorambucil is potentially mutagenic, teratogenic and ...
Solid-Phase Organic Synthesis: Bicyclic Peptides and Purine-Derived Small Molecules
(Turun yliopistoAnnales Universitatis Turkuensis A I 474, 2013-11-15)
Brown algal phlorotannins: Improving and applying chemical methods
(Turun yliopistoAnnales Universitatis Turkuensis AI 381, 2008-02-22)
Phlorotannins are the least studied group of tannins and are found only in brown algae. Hitherto the roles of phlorotannins, e.g. in plant-herbivore interactions, have been studied by quantifying the total contents of the ...
The Significance of Hydrogen Bonding Interactions in the Cleavage of RNA
(Turun yliopistoAnnales Universitatis Turkuensis A I 418, 2011-05-20)
RNA is essential for all living organisms. It has important roles in protein synthesis, controlling gene expression as well as catalyzing biological reactions. Chemically RNA is a very stable molecule, although in biological ...
Synthesis of Short Oligonucleotides on a Soluble Support by the Phosphoramidite Method
(Turun yliopistoAnnales Universitatis Turkuensis A I 521, 2015-09-04)
In the last decades, the chemical synthesis of short oligonucleotides has become an important aspect of study due to the discovery of new functions for nucleic acids such as antisense oligonucleotides (ASOs), aptamers, ...
Prodrug strategies of antiviral nucleotides: Studies on enzymatically and thermally removable phosphate protecting groups
(Turun yliopistoTurun yliopiston julkaisuja - Annales Universitatis Turkuensis. Sarja - ser. AI osa - tom. 522, 2015-09-18)
Antiviral nucleosides are compounds that are used against viruses, such as human immunodeficiency virus (HIV) and hepatitis C virus (HCV). To act as therapeutic agent, the antiviral nucleoside needs to be phosphorylated ...