Aineistot 1-10 / 12
Expression and role of decorin in human epithelial cancers - with special reference to bladder, colon and vulva carcinomas
(Turun yliopisto, 2019-05-11)
Today, the extracellular matrix (ECM) is not only known for its structural role but also for its many functional roles that are critical in the pathogenesis of various diseases including carcinogenesis. This is also true ...
The role of snorc, a novel cartilage transmembrane proteoglycan in skeletal tissue homeostasis
(Turun yliopisto, 2017-12-07)
Discovery of molecular mechanisms underlying chondrogenesis is necessary to develop therapies for skeletal disorders and articular cartilage defects or disorders like osteoarthritis (OA). Specific properties of each ...
ANO7 in aggressive prostate cancer
(Turun yliopisto, 2020-03-13)
A significant proportion of men develop prostate cancer during their lifetime, which causes challenges for public health. PSA screening studies have shown that testing all men at specific ages causes overdiagnosis of ...
New functions for the cellular oxygen sensor PHD3 in clear cell renal cell carcinoma
(Turun yliopisto, 2018-05-18)
The family of HIF prolyl hydroxylase enzymes (PHDs) is known for their function of post-translationally regulating hypoxia-inducible transcription factors (HIFs) in oxygen-dependent manner. HIFs are the key transcription ...
The effects of soluble activin type IIB receptor on bone formation and body composition
(Turun yliopisto, 2018-05-04)
Bone tissue is a dynamic organ which undergoes constant remodeling through a coupled series of events in order to maintain proper skeletal structure and calcium-phosphate homeostasis. In addition to its mechanical properties, ...
Focal adhesion mediated regulation of pluripotency : The role of focal adhesions and contractile forces in human pluripotent stem cells
(Turun yliopisto, 2019-11-29)
Human pluripotent stem cells (hPSCs) hold great promise for future medicine. They can differentiate to all adult cell types and self-replicate virtually endlessly. These features would make hPSCs a valuable tool for ...
Osteoblastien erilaistumisen ja toiminnan transkriptionaalinen säätely
(Turun yliopisto, 2017-02-17)
Characterization of Gamma-Secretase-Mediated Cleavage of Receptor Tyrosine Kinases
(Turun yliopisto, 2021-09-10)
ABSTRACT Receptor tyrosine kinases (RTK) are a family of cell surface receptors consisting of 55 members. RTKs regulate intracellular signaling pathways that control fundamental cellular processes including differentiation, ...
Implementation of modern methods to identify DNA methylation marks for episodic memory impairment and Alzheimer’s disease
(Turun yliopisto, 2020-10-23)
Alzheimer’s disease (AD) is a progressive neurodegenerative disease and a common cause of dementia worldwide. The pathogenic mechanisms of AD are not completely understood. Both genetic and external factors, like lifestyle ...
Wnt signaling in the regulation of bone and cartilage metabolism
(Turun yliopisto, 2021-10-22)
Bone is a dynamic organ that is remodeled in a continuous cycle of bone formation by osteoblasts and bone resorption by osteoclasts. Extensive studies have revealed that bone remodeling can be modulated by multiple signaling ...